The Role of G-CSF in Host Defense Mechanisms of the Elderly.

Inoue, Masahiko; Hashimoto, Shigeo; Nakaya, Yoshiaki; Horie, Takashi

doi:10.3143/geriatrics.30.480

Cited by 1 publication

(2 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our results show that with increasing age, the intracellular killing activity of PMNs, which have an important role in the cellular-mediated mechanism of immunity in elderly patients, decreased signifi cantly when compared with that of healthy young volunteers, a result similar to previous reports [2,7,12] . Also the intracellular killing activity of PMNs from elderly patients with hypertension and DM decreased, but their phagocytic activity did not signifi cantly decrease when compared with that of healthy young volunteers.…”

Section: Discussionsupporting

confidence: 80%

See 1 more Smart Citation

Comparison of Polymorphonuclear Leukocyte Functions in Elderly Patients and Healthy Young Volunteers

Göçer

Gürer²,

Erten³

et al. 2005

Med Princ Pract

View full text Add to dashboard Cite

Objective: To compare the polymorphonuclear leukocyte (PMN) functions (phagocytosis and intracellular killing activity) of elderly patients with healthy young volunteers. Subjects and Methods: Fifty-nine elderly patients who had various diseases (cancer, hypertension and diabetes mellitus, DM) and 10 healthy young volunteers were included in this study. Ficoll-Hypaque gradient centrifugation was used to isolate PMNs from venous blood containing EDTA (0.1 g/ml). Phagocytosis and intracellular killing activity of neutrophils were assayed using a modification of Alexander’s method, in which serum opsonins, number of neutrophils and number of microorganisms are standardized in order to detect both increases and decreases in phagocytosis and intracellular killing as well as combined abnormalities of these two functions. The least significant difference test was used to compare the results in the two groups. Results: Phagocytic activity of PMNs from patients with cancer was significantly higher than that of healthy young volunteers (p < 0.05) and elderly patients with hypertension and DM (p < 0.05). There was no statistical difference between the phagocytic activity of PMNs from elderly patients with hypertension and DM and healthy young volunteers (p > 0.05). The intracellular killing activity of PMNs from elderly patients with hypertension, DM and cancer was significantly lower than that of healthy young volunteers (p = 0.001, p < 0.0001, p = 0.003, respectively). Conclusions: The intracellular killing activity of PMNs from elderly patients was significantly decreased when compared with that of healthy young volunteers. Ageing, chronic diseases and drugs used in the treatment of these elderly patients may be the cause for decreased intracellular killing activity.

show abstract

Section: Discussionsupporting

confidence: 80%

“…The least signifi cant difference test was used to compare the results in the two groups. Results: Phagocytic activity of PMNs from patients with cancer was signifi cantly higher than that of healthy fer higher rates of morbidity and mortality from infections, possibly autoimmune diseases and cancer [1][2][3][4] .…”

Section: Introductionmentioning

confidence: 99%