The Role of Fungi in Atopic Dermatitis

Glatz, Martin; Bosshard, Philipp P.; Schmid‐Grendelmeier, Peter

doi:10.1016/j.iac.2016.08.012

Cited by 31 publications

(32 citation statements)

References 63 publications

(43 reference statements)

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“…Possible causes include a false positive IDT result in a dog with atopic‐like dermatitis and additional unrecognized FIAD or environmental hypersensitivities. It is also currently unknown if dogs could develop auto‐immunity to Malassezia allergen analogues as recognized in humans …”

Section: Discussionmentioning

confidence: 99%

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Results of allergen‐specific immunotherapy in atopic dogs withMalasseziahypersensitivity: a retrospective study of 16 cases

Åberg¹,

Varjonen

Åhman³

2017

Veterinary Dermatology

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Section: Discussionmentioning

confidence: 99%

“…play multiple roles in the pathogenesis of human atopic dermatitis (AD). Malassezia dermatitis and immunoglobulin E (IgE)‐mediated hypersensitivity to Malassezia spp may cause exacerbation of clinical signs . Hypersensitivity to Malassezia pachydermatis also occurs in atopic dogs; hereafter designated as MHS .…”

Section: Introductionmentioning

confidence: 99%

Results of allergen‐specific immunotherapy in atopic dogs withMalasseziahypersensitivity: a retrospective study of 16 cases

Åberg¹,

Varjonen

Åhman³

2017

Veterinary Dermatology

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“…According to the PubMed database, more than 300 research articles on the association between AD and Malassezia were published in between 1985 and 2018. This number included several extensive reviews, analysing multiple aspects of the issue including epidemiology, mycological, immune response and therapy. The number of papers covering Malassezia in the title and abstract exceeded 1760 (29.11.2018).…”

Section: Therapeutic Implicationsmentioning

confidence: 99%

Section: Ther Apeutic Implic Ationsmentioning

confidence: 99%

Contribution of Malassezia spp. to the development of atopic dermatitis

Nowicka

Nawrot

2019

Mycoses

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Summary The prevalence of atopic dermatitis (AD) has been increasing. Whereas AD symptoms are obvious and easy to recognise, the etiopathogenesis remains not fully elucidated. Recently, the role of microorganisms and their impact on the immunology of AD have been discussed. In this review, we summarise a possible role of Malassezia in the development and persistence of eczema in patients with atopic eczema/dermatitis syndrome. A high proportion of AD patients present with a positive reaction to Malassezia allergens. Several possible pathogenic mechanisms enable Malassezia to trigger the development of AD. Malassezia spp. may release more allergens in a less acidic (pH <6), typical for AD, environment. The similarity between fungal thioredoxin and human proteins causes T‐cell cross‐reactivity. TLR‐mediated mechanisms are involved in host response against Malassezia spp. An interaction between Malassezia spp. and keratinocytes alters the profile of cytokine release, and what is more, yeast cells can survive when absorbed by keratinocytes. Dendritic cells of AD patients induced by Malassezia are less susceptible to lysis mediated by NK cells which exerts a pro‐inflammatory effect. Despite the evidence that Malassezia spp. contribute to the development of AD, the pathogenetic mechanisms and relationship between Malassezia and immune defense remain partly unexplained and require further research.

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“…Recent studies have revealed that the fungi compose 1% to 22% of the normal skin microbiome, the most common species being Malassezia. 45 Malassezia spp rely on exogenous lipids for their metabolic requirement. Malassezia spp, as part of the normal skin microbiome, interact with cutaneous dendritic cells or lymphocytes.…”

Section: Allergic Dermatitismentioning

confidence: 99%

Atopic dermatitis: addressing allergy, infection, itch and complementary therapies

et al. 2017

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Atopic dermatitis (AD) is a complex condition that results from the dynamic interplay between genetic predisposition, skin barrier defects, environmental factors, and a dysfunctional immune system. As a result, AD can be complicated by irritant and allergic contact dermatitis and imbalances in the skin microbiome, which can subsequently exacerbate the severity and complicate the course of preexisting atopic disease. Itch is an important symptom of AD, as it plays a large role in the quality of life of patients and their families. Since AD is a chronic, inflammatory disease that recrudesces throughout life, many have utilized alternative and/or complementary therapies, as monotherapy or in conjunction with conventional therapies, as a form of management.

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The Role of Fungi in Atopic Dermatitis

Cited by 31 publications

References 63 publications

Results of allergen‐specific immunotherapy in atopic dogs withMalasseziahypersensitivity: a retrospective study of 16 cases

Results of allergen‐specific immunotherapy in atopic dogs withMalasseziahypersensitivity: a retrospective study of 16 cases

Contribution of Malassezia spp. to the development of atopic dermatitis

Atopic dermatitis: addressing allergy, infection, itch and complementary therapies

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