The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients

Bandstein, Marcus; Schultes, Bernd; Ernst, Barbara; Thurnheer, Martin; Schiöth, Helgi B.

doi:10.1007/s11695-015-1644-4

Cited by 21 publications

(19 citation statements)

References 32 publications

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“…These were divided into categories according to the type of the surgical procedure and the dose range of vitamin D supplementation. Only eight studies showed a mean 25(OH)D level > 30 ng/ml at 6 to 24 months post operatively [51,52,60,66,69,73,75,80]. Thirteen studies showed a mean 25(OH)D level < 20 ng/ml at 6 months to 11 years post operatively [51,54,55,64,78,85–92].…”

Section: Resultsmentioning

confidence: 99%

“…Conversely, studies administering a maintenance vitamin D supplementation of 400–2,000 IU daily, and additional doses to deficient and/or insufficient individuals (additional equivalent dose range 1,100 IU–7,100 IU, total daily dose received 1,500–9,100 IU), with the exception of Fish et al [69], consistently demonstrated an increase in mean 25(OH)D level of 9–13 ng/ml at six months [59] (Appendix), and at one year post operatively (Figure 3) [52,60,62,66,73,75]. The mean baseline 25(OH)D level in this group of studies was 13–25 ng/ml.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, studies that administered vitamin D, as a maintenance dose to all participants (≤2,000 IU daily), and additional doses (range of equivalent daily doses: 1,100–7,100 IU, total daily dose received 1,500–9,100 IU) to vitamin D deficient/insufficient individuals, following malabsorptive and combination procedures, achieved a mean 25(OH)D level above 20 ng/ml in five studies, with mean baseline 25(OH)D level 13–21 ng/ml [53,59,62,69,100], and above 30 ng/ml in six studies, with mean baseline 25(OH)D level 15–25 ng/ml [52,60,66,69,73,75] (Figure 3 and Appendix). …”

Section: Resultsmentioning

confidence: 99%

“…Considering studies of vitamin D deficient individuals, these proportions increased from 25–55% at baseline, to 70–93% of at study completion, on replacement doses and add-on to the vitamin D maintenance regimen [52,53,59,60,62,69,73,75]. …”

Section: Resultsmentioning

confidence: 99%

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Hypovitaminosis D in bariatric surgery: A systematic review of observational studies

et al. 2016

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Background Obesity is a public health problem that carries global and substantial social and economic burden. Relative to non-surgical interventions, bariatric surgery has the most substantial and lasting impact on weight loss. However, it leads to a number of nutritional deficiencies requiring long term supplementation. Objectives The aims of this paper are to review 25-hydroxyvitamin D [25(OH)D] status pre and post - bariatric surgery, describe the dose response of vitamin D supplementation, and assess the effect of the surgical procedure on 25(OH)D level following supplementation. Methods We searched Medline, PubMed, the Cochrane Library and EMBASE, for relevant observational studies published in English, from 2000–April 2015. The identified references were reviewed, in duplicate and independently, by two reviewers. Results We identified 51 eligible observational studies assessing 25(OH)D status pre and/or post bariatric surgery. Mean pre-surgery 25(OH)D level was below 30 ng/ml in 29 studies and 17 of these studies showed mean 25(OH)D levels ≤ 20 ng/ml. Mean 25(OH)D levels remained below 30 ng/ml following bariatric surgery despite various vitamin D replacement regimens, with only few exceptions. The increase in postoperative 25(OH)D levels tended to parallel increments in vitamin D supplementation dose but varied widely across studies. An increase in 25(OH)D level by 9–13 ng/ml was achieved when vitamin D deficiency was corrected using vitamin D replacement doses of 1,100–7,100 IU/day, in addition to the usual maintenance equivalent daily dose of 400 – 2,000 IU (total equivalent daily dose 1,500–9,150 IU). There was no difference in mean 25(OH)D level following supplementation between malabsorptive/ combination procedures and restrictive procedures. Conclusion Hypovitaminosisis D persists in obese patients undergoing bariatric surgery, despite various vitamin D supplementation regimens. Further research is needed to determine the optimal vitamin D dose to reach desirable 25(OH)D levels in this population, and to demonstrate whether this dose varies according to the surgical procedure.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Hypovitaminosis D in bariatric surgery: A systematic review of observational studies

et al. 2016

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“…FTO risk allele carriers lose less weight than common allele homozygous individuals after banding surgery [222,223], but experience a similar level or more weight reduction after gastric bypass surgery [222,224].…”

Section: Obesity-predisposing Gene Variants Interact With Bariatric Smentioning

confidence: 99%

The importance of gene–environment interactions in human obesity

2016

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The worldwide obesity epidemic has been mainly attributed to lifestyle changes. However, who becomes obese in an obesity-prone environment is largely determined by genetic factors. In the last 20 years, important progress has been made in the elucidation of the genetic architecture of obesity. In parallel with successful gene identifications, the number of gene-environment interaction (GEI) studies has grown rapidly. This paper reviews the growing body of evidence supporting gene-environment interactions in the field of obesity. Heritability, monogenic and polygenic obesity studies provide converging evidence that obesity-predisposing genes interact with a variety of environmental, lifestyle and treatment exposures. However, some skepticism remains regarding the validity of these studies based on several issues, which include statistical modelling, confounding, low replication rate, underpowered analyses, biological assumptions and measurement precision. What follows in this review includes (1) an introduction to the study of GEI, (2) the evidence of GEI in the field of obesity, (3) an outline of the biological mechanisms that may explain these interaction effects, (4) methodological challenges associated with GEI studies and potential solutions, and (5) future directions of GEI research. Thus far, this growing body of evidence has provided a deeper understanding of GEI influencing obesity and may have tremendous applications in the emerging field of personalized medicine and individualized lifestyle recommendations.

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Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis

Giustina,

di Filippo,

Facciorusso

et al. 2023

Rev Endocr Metab Disord

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Bariatric surgery is associated with a postoperative reduction of 25(OH) vitamin D levels (25(OH)D) and with skeletal complications. Currently, guidelines for 25(OH)D assessment and vitamin D supplementation in bariatric patients, pre- and post-surgery, are still lacking. The aim of this work is to analyse systematically the published experience on 25(OH)D status and vitamin D supplementation, pre- and post-surgery, and to propose, on this basis, recommendations for management. Preoperatively, 18 studies including 2,869 patients were evaluated. Prevalence of vitamin D insufficiency as defined by 25(OH)D < 30 ng/mL (75 nmol/L) was 85%, whereas when defined by 25(OH)D < 20 ng/mL (50 nmol/L) was 57%. The median preoperative 25(OH)D level was 19.75 ng/mL. After surgery, 39 studies including 5,296 patients were analysed and among those undergoing either malabsorptive or restrictive procedures, a lower rate of vitamin D insufficiency and higher 25(OH)D levels postoperatively were observed in patients treated with high-dose oral vitamin D supplementation, defined as ≥ 2,000 IU/daily (mostly D3-formulation), compared with low-doses (< 2,000 IU/daily). Our recommendations based on this systematic review and meta-analysis should help clinical practice in the assessment and management of vitamin D status before and after bariatric surgery. Assessment of vitamin D should be performed pre- and postoperatively in all patients undergoing bariatric surgery. Regardless of the type of procedure, high-dose supplementation is recommended in patients after bariatric surgery.

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The Role of FTO and Vitamin D for the Weight Loss Effect of Roux-en-Y Gastric Bypass Surgery in Obese Patients

Cited by 21 publications

References 32 publications

Hypovitaminosis D in bariatric surgery: A systematic review of observational studies

Hypovitaminosis D in bariatric surgery: A systematic review of observational studies

The importance of gene–environment interactions in human obesity

Vitamin D status and supplementation before and after Bariatric Surgery: Recommendations based on a systematic review and meta-analysis

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