The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis

Pektaş, Suzan Demir; Doğan, Gürsoy; Edgünlü, Tuba Gökdoğan; Karakas-Celik, Sevim; Ermis, Esra; Tekin, Nilgün Solak

doi:10.4103/ijd.ijd_409_17

Indian J Dermatol

2018

DOI: 10.4103/ijd.ijd_409_17

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The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis

Suzan Demir Pektaş

Gürsoy Doğan

Tuba Gökdoğan Edgünlü

et al.

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Cited by 4 publications

References 33 publications

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FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children

Wang

Fang³

et al. 2019

J of Cellular Biochemistry

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Acute lymphoblastic leukemia (ALL) is the most frequently diagnosed cancer in children and single‐nucleotide polymorphisms (SNPs) in certain genes influence risk of ALL. Although FOXO3 had been demonstrated to be involved leukemia, the role of FOXO3 polymorphisms was still not clear. In the present study, we explored the association of FOXO3 SNPs with ALL risk in Chinese children. We genotyped four polymorphisms (rs17069665 A>G, rs4945816 T>C, rs4946936 C>T, and rs9400241 A>C) of FOXO3 in 425 ALL cases and 1339 health controls. The associations were estimated by odds ratios (ORs) with their 95% confidence intervals (CIs). Further analyses were performed to explore associations of rs17069665 and rs9400241 with ALL susceptibility in terms of age, gender, immunophenotype, minimal residual disease (MRD), and other clinical characteristics. We found rs17069665 related to the increased ALL risk (OR = 1.76; 95% CI = 1.02‐3.04), rs9400241 related to decreased ALL risk (OR = 0.80; 95% CI = 0.64‐0.99). The effects of rs17069665 on ALL risk were more predominant in males and children < 10 years, and patients with lower rates of platelet or neutrophil. As for rs9400241, the effects were more predominant in children < 10 years, and in patients with pre B ALL, positive MRD, anemia, or hepatomegaly. In conclusion, FOXO3 gene polymorphisms influence the risk of ALL in children and might be a potential biomarker for ALL susceptibility.

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FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children

Wang

Fang³

et al. 2019

J of Cellular Biochemistry

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Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity

Ding

et al. 2020

iScience

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Dendritic cells (DCs) function is intimately linked to microenvironment and metabolism. Type I interferons (IFNs) condition dendritic cells to respond to weak self-signals, leading to autoimmunity. However, the metabolic adaption in the process is unclear. Here, we identified spermidine as a critical metabolite impacting the metabolic fitness of DC. First, dynamic metabolome screening indicated that spermidine decreased during IFN priming and following TLR7 ligand stimulation, accompanied by metabolic change from oxidative phosphorylation to glycolysis. Second, spermidine supplement restrained the glycolysis and prevented the overactivation of IFN-a primed DC both in vivo and in vitro. Third, mechanism study uncovered that the activity of FOXO3 adapted to the metabolic change, mediating the anti-inflammatory effect of spermidine. More importantly, addition of spermidine in vivo greatly alleviated the development of psoriasis-like symptom in mice. Thus, our studies revealed metabolic changes boosting DC responses and identified spermidine as a potential therapeutic agent for autoimmune diseases.

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Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis

Zhou

et al. 2021

Int J of Rheum Dis

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Aim Previous studies have shown that silent information regulator 1 (SIRT1) expression is elevated in rheumatoid arthritis (RA) patients. However, whether gene polymorphisms in SIRT1 gene associated with RA in a Chinese Han population remains to be discussed. Method In this case‐control study, 529 RA patients and 700 healthy controls were selected, and association of 11 SIRT1 gene polymorphisms (rs12415800, rs3740051, rs932658, rs3740053, rs7895833, rs10509291, rs33957861, rs7069102, rs2273773, rs3818292, rs1467568) with RA susceptibility was evaluated. Results Frequency of GA+GG genotype of rs3740051 in RA patients was significantly lower than that in healthy controls (P = .037). Frequencies of GC and GC+GG genotypes of rs7069102 were significantly lower than those in healthy controls (P = .036, P = .047). Frequencies of GA and GA+GG genotypes of rs1467568 were lower in RA patients as compared to those in healthy controls (P = .011, P = .013). For rs2273773, RA patients who carried the T allele had higher number of tender joints than patients who carried the C allele (P = .033). Other polymorphisms did not associate with RA risk. Conclusion The findings suggest that rs3740051, rs7069102 and rs1467568 variants in SIRT1 gene are related to RA susceptibility in a Chinese Han population.

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The role of forkhead box class O3A and SIRT1 gene variants in early-onset psoriasis

Cited by 4 publications

References 33 publications

FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children

FOXO3 gene polymorphisms influence the risk of acute lymphoblastic leukemia in Chinese children

Spermidine Suppresses Inflammatory DC Function by Activating the FOXO3 Pathway and Counteracts Autoimmunity

Gene polymorphisms of SIRT1 in patients with rheumatoid arthritis

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