The role of food allergy in the development of atopic  dermatitis. Position paper of the Association  of Children's Allergists and Immunologists of Russia

Smolkin, Yuri S.; Masalskiy, Sergei S.; Чебуркин, А А; Горланов, И. А.

doi:10.26442/26586630.2020.1.200019

Cited by 3 publications

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“…Пищевая аллергия (ПА) представляет собой значимую проблему современного здравоохранения, и с каждым годом её распространённость в разных странах мира только растёт[1,2]. Клинические проявления ПА многообразны и включают в себя кожные симптомы, реакции со стороны пищеварительной системы и дыхательных путей, анафилаксию и др.…”

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Delayed allergic reaction to eating lemon

Prilutskiy

Lygina

2022

Russian Journal of Allergy

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Allergy to lemon can be caused by both IgE-mediated and IgG-dependent mechanisms, or have a combined IgE/IgG-dependent origin. For the first time, a clinical case of a combined immediate and delayed allergic reaction to eating lemon, which manifests itself in the form of oral allergic syndrome and gastrointestinal symptoms, in a 31-year-old woman was described. The patient was diagnosed with polysensitization to various food, household and pollen antigens, cross-allergy to fruits of the Rutaceae family (orange, tangerine, grapefruit). With the help of a prick+prick test and an enzyme-linked immunosorbent assay, she was diagnosed with allergy and sensitization to the allergens of lemon pulp. The presence of one or more thermolabile antigens in lemon pulp, causing immediate and delayed allergy symptoms, has been established. The ability of thermolabile allergens and/or individual antigenic determinants to induce delayed allergic reactions, despite the action of proteolytic enzymes of the gastrointestinal tract and hydrochloric acid, has been established. To establish the resistance of individual antigenic epitopes of lemon allergens to the effects of various factors of the gastrointestinal tract, additional studies are required to establish the sensitivity of protein molecules of allergens to these factors.

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Delayed allergic reaction to eating lemon

Prilutskiy

Lygina

2022

Russian Journal of Allergy

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Persistent food allergy to cow’s milk proteins. How to form tolerance?

Lepeshkova

2022

Allergol. immunol. pediatr.

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Clinical case of early debut of food allergy in a child up to 6 months

Masalskiy

Smolkin²,

Smolkina

2022

Allergol. immunol. pediatr.

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Introduction: It is believed that if the child ate only a cow’s milk formula (CMF), and сow's milk allergy is the only possible at the age of <6 months. This approach leads to erroneous treatment tactics. Presentation of the clinical case: a child aged 3 months with the debut of atopic dermatitis (AtD) of light degree (on the scale of the assessment of the researcher IGA 2). The patient was fed on artificial with a CMF from 1,5 months. Infant was examined at the place of residence. The CMF was changed to full hydrolysis CMF and without examination. Additionally, cosmetics were applied to the skin as needed. The child was examined by an allergologist after 3-4 weeks of diet. Negative dynamics were observed. Atopic dermatitis has become moderately severe with secondary infection complications (IGA 3, 50% affected skin). Prick-tests with allergens of milk, eggs, wheat, fish were carried out. High sensitization to egg and controversial to cow’s milk was found. The results were clarified during enzyme immunoassay: IgE ovomucoid – 0.78 IU/ml (norm <0.3 IU/ml); cow's milk 0.01 kUA/ l; casein – 0.01 kUA / l (norm <0.1 kUA/l). Considering the infected AtD, "hydrocortisone + natamycin + neomycin" 2 times a day was used in the therapy. Cosmetics on infected foci was canceled, while maintaining the treatment of dry unaffected skin. It is recommended to limit household contacts with eggs. After 2 weeks, the rash is residual (IGA 0-1). The cow’s milk formula was returned to the diet without exacerbations of the skin process. Conclusion: The case illustrates that sensitization in children can begin and be maintained without oral ingestion of the allergen. Sensitization at the age of up to 6 months is likely with a moderate – severe recurrent course of dermatitis. A specific allergological examination can be conduct with a developed disease at an early age. Skin tests and enzyme immunoassay are applicable in infants. The appointment of a diet without examination is unreasonable and should not be used.

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The role of food allergy in the development of atopic dermatitis. Position paper of the Association of Children's Allergists and Immunologists of Russia

Cited by 3 publications

References 0 publications

Delayed allergic reaction to eating lemon

Delayed allergic reaction to eating lemon

Persistent food allergy to cow’s milk proteins. How to form tolerance?

Clinical case of early debut of food allergy in a child up to 6 months

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