The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip tea

Frész, Tamás; Nagy, É.; Hilbert, Ágnes; Tomcsányi, János

doi:10.1016/j.ijcard.2013.11.090

Cited by 2 publications

(2 citation statements)

References 4 publications

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“…Studies have confirmed the presence of digoxin-like factors in Rugosa Thunb. (Meiguihua), Flos Hibisci Mutabilis (Furonghua), and its flavonoids, glycosides, and quercetol ( Frész et al, 2014 ), which cause false-positive results in digoxin assays.…”

Section: Effect Of Tcm On Pharmacodynamics Mechanism Of Digoxinmentioning

confidence: 99%

Interaction between Chinese medicine and digoxin: Clinical and research update

Zhuang

He²,

Jia³

et al. 2023

Front. Pharmacol.

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Background: Digoxin is one of the most widely and commonly used cardiac drug, which plays an irreplaceable role in treating heart failure and arrhythmia. The 2010 Edition of Pharmacopoeia of the People’s Republic of China stipulates that the effective range of digoxin plasma concentration is 0.5–2.0 ng/mL and it is toxic at plasma concentration >2 ng/mL. Its effective plasma drug concentration is close to the toxic concentration, and large individual differences in the effects of the drug have been observed. It is often used in combination with other drugs, but drug interactions have a great impact on the plasma concentration of digoxin and lead to adverse reactions (ADRs), such as poisoning. Most of the reported drug interactions are with Western drugs. However, there are many combinations of traditional Chinese medicine (TCM) and Western drugs, TCM interacting with digoxin comprises monomer components, single medicines, and Chinese patent medicines.Aim of the study: We aimed i) to provide an overview of the TCM formulations affecting the pharmacology of digoxin and their mechanisms of action and ii) to provide a theoretical reference for the safe and rational use of digoxin in combination with TCM in clinical practice and to avoid ADRs.Methods: A literature search of electronic databases, including PubMed, MEDLINE, Cochrane Library, Web of Science, China National Knowledge Infrastructure, and WANFANG Data, was performed to search for articles published between 1 January 1960, and 1 August 2022. Search terms used included “digoxin,” “traditional Chinese medicine,” “Chinese patent medicine,” and “adverse reactions” and their combinations.Results: A total of 49 articles were obtained, including clinical reports, pharmacological experiments and in vitro experiments. The mechanisms of action affecting the pharmacology of digoxin are complex. TCM formulations may affect the pharmacology of digoxin in vivo by influencing gastrointestinal motility or gastric juice pH, regulating P-glycoprotein levels, exerting cumulative pharmacological effects, and enhancing the sensitivity of the heart to digoxin. Although studies have shown that some TCM formulations interact with digoxin, they may be influenced by the complexity of the composition and the pharmacological effects of the TCM, the sensitivity of digoxin concentration determination methods, etc. The results of existing studies are controversial and further in-depth studies are required.Conclusion: Combinations of digoxin and TCM formulations are commonly used. This article serves as a reference to understand the interactions between TCM formulations and digoxin to avoid the occurrence of ADRs and improve the efficacy and safety of digoxin.

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Section: Effect Of Tcm On Pharmacodynamics Mechanism Of Digoxinmentioning

confidence: 99%

Interaction between Chinese medicine and digoxin: Clinical and research update

Zhuang

He²,

Jia³

et al. 2023

Front. Pharmacol.

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“…Moreover, carbon materials can be produced from waste biomass, including soil waste such as ginkgo leaves, pineapple leaves, tea extract, mango peels, and banana peels [19][20][21][22][23][24], thereby reducing soil pollution and making the best use of resources. Hibiscus sabdariffa is one of the most commonly used ingredients in commercial herbal tea [25]. H. sabdariffa has been traditionally used in the food industry for herbal drinks or as a flavoring agent [26][27][28].…”

Section: Introductionmentioning

confidence: 99%

Synthesis of Photoluminescent Carbon Dots Using Hibiscus Tea Waste and Heteroatom Doping for Multi-Metal Ion Sensing: Applications in Cell imaging and Environmental Samples

Mohandoss,

Ahmad,

Velu

et al. 2023

Chemosensors

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Novel photoluminescent carbon dots (CDs) were synthesized through a facile hydrothermal method using Hibiscus tea extract as a natural carbon source and boric acid as a boron source. The optical and physicochemical properties of the as-synthesized nitrogen- and boron-doped CDs (NB-CDs) were characterized using UV–Visible (UV–Vis), photoluminescence (PL) spectroscopy, Fourier-transform infrared (FTIR), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The as-synthesized NB-CDs showed spherical morphology of approximately 6.2 ± 0.5 nm with quantum yield (9.2%), high aqueous solubility, strong photo-stability, and excitation-dependent PL behavior. The obtained NB-CDs exhibited high stability over a wide pH range and high ionic strength. Additionally, NB-CDs exhibited PL enhancement response with excellent sensitivity toward multi-metal ions, including Ag+, Cd2+, and Cr3+ ions, with very low detection limits of 44.5, 164.4, and 54.6 nM, respectively, with a wide concentration range of 0–10 μM. Upon testing the cytotoxicity of the NB-CDs at a concentration of 20 μg/mL for 24 h, we found no obvious inhibition of cell viability. Therefore, the proposed sensor method can be successfully applied to detect Ag+, Cd2+, and Cr3+ ions in cell imaging as well as in real water environmental samples.

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The role of flavonoids in false positive digoxin assays caused by the consumption of hibiscus flower and rose hip tea

Cited by 2 publications

References 4 publications

Interaction between Chinese medicine and digoxin: Clinical and research update

Interaction between Chinese medicine and digoxin: Clinical and research update

Synthesis of Photoluminescent Carbon Dots Using Hibiscus Tea Waste and Heteroatom Doping for Multi-Metal Ion Sensing: Applications in Cell imaging and Environmental Samples

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