The role of fish intake on asthma in children: A meta‐analysis of observational studies

Papamichael, Maria Michelle; Shrestha, Som Kumar; Itsiopoulos, Catherine; Erbas, Bircan

doi:10.1111/pai.12889

Cited by 63 publications

(44 citation statements)

References 59 publications

(247 reference statements)

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“…A possible explanation as to why we did not observe any change in spirometry with fatty fish intake could be because children had normal lung function and well‐controlled asthma. On the other hand, our recent meta‐analysis investigating the role of fish intake in childhood asthma documented that early introduction and regular intake of fish (at least once a week) was beneficial on ‘current wheeze’ [odds ratio (OR) = 0.62; 95% CI = 0.48–0.80] and ‘current asthma’ (OR = 0.75; 95% CI = 0.60–0.95) in children up to 4.5 years old, whereas fatty fish intake was protective for ‘current asthma’ in children aged 8–14 years (OR = 0.35; 95% CI = 0.18–0.67) . However, in the majority of these studies, asthma outcome was assessed using a questionnaire and not by spirometry.…”

Section: Discussionmentioning

confidence: 99%

“…One fish meal can provide between 1.5–3.0 g of EPA/DHA and 1 g of fish oil capsule per day can provide approximately 300 mg . Most of the epidemiological evidence giving rise to the hypothesis that marine omega‐3 fatty acids might have a prophylactic effect was generated from observational studies reporting that an early introduction in life and regular consumption of fish in children had a protective effect on asthma in children aged up to 14 years old . Thus, fish, consisting of an array of bioactive nutrients, including EPA, DHA and antioxidants, might have a different health impact compared to fish oil supplementation .…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Papamichael

Katsardis

Lambert

et al. 2018

J Human Nutrition Diet

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How to cite this article Papamichael M.M., Katsardis Ch., Lambert K., Tsoukalas D., Koutsilieris M., Erbas B., Itsiopoulos C. (2019) Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial. J Hum Nutr Diet. 32,[185][186][187][188][189][190][191][192][193][194][195][196][197] .https://doi. AbstractBackground: Childhood asthma is the most common respiratory disorder worldwide, being associated with increased morbidity and a decreased quality of life. Omega-3 fatty acids have anti-inflammatory and immunomodulating properties; however, their efficacy in asthma is controversial. The present study aimed to examine the efficacy of a Mediterranean diet supplemented with a high omega-3 'fatty' fish intake in Greek asthmatic children.Methods: A single-centred, 6-month, parallel randomised controlled trial compared the consumption of a Mediterranean diet supplemented with two meals of 150 g of cooked fatty fish weekly (intervention) with the usual diet (control) with respect to pulmonary function in children (aged 5-12 years) with mild asthma. Pulmonary function was assessed using spirometry and bronchial inflammation by fractional exhaled nitric oxide analysis. Results: Sixty-four children (52% male, 48% female) successfully completed the trial. Fatty fish intake increased in the intervention group from 17 g day À1 at baseline to 46 g day À1 at 6 months (P < 0.001). In the unadjusted analysis, the effect of the intervention was of borderline significance (P = 0.06, b = À11.93; 95% confidence interval = À24.32 to 0.46). However, after adjusting for age, sex, body mass index and regular physical activity, a significant effect was observed (P = 0.04, b = À14.15 ppb; 95% confidence interval = À27.39 to À0.91). No difference was observed for spirometry, asthma control and quality of life scores. Conclusions: A Mediterranean diet supplemented with two fatty fish meals per week might be a potential strategy for reducing airway inflammation in childhood asthma. Future robust clinical trials are warranted to replicate and corroborate these findings.185

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Papamichael

Katsardis

Lambert

et al. 2018

J Human Nutrition Diet

Self Cite

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“…With regard to fish allergy, an observational study, prospectively following infants from birth to 4 years of age, documented that regular fish consumption before 12 months of age was associated with a reduced risk of allergic disease and sensitization at 4 years of age (51). Consistently, results from another meta-analysis, aiming to specifically clarify the role of fish intake on different asthma outcomes in children, demonstrated that early introduction (between 6 and 9 months of age) and regular consumption of fish (at least once a week) decreased the risk, prevalence, and symptoms of asthma in children up to 14 years of age (52).…”

Section: Cereals and Fishmentioning

confidence: 99%

Nutrition and Avoidance Diets in Children With Food Allergy

et al. 2020

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Food allergy (FA) is a significant health issue which considerably influences the quality of life of both children and their family. The increasing prevalence of FA, documented in the last 3 decades, has led to the reassessment of FA prevention strategies and particularly to giving up the approach based on delaying the introduction of potential food allergens. Several observational and interventional studies demonstrated a potential effectiveness of the early food introduction strategy in FA prevention, although strong evidence from randomized controlled trials are lacking and, sometimes, contrasting. The current approach to FA is mainly based on avoidance diet and the use of rescue medications in case of allergic reaction, although active allergen immunotherapy has recently become an increasingly important therapeutic strategy to approach IgE-mediated FA, potentially able to induce improvement through desensitization to a specific food. This review provides an overview on the historical evolution of recommendations about FA and on evidence published in the last 15 years on nutritional intervention strategy, i.e., early introduction of allergen or avoidance diet, in the prevention and management of IgE-mediated and non-IgE-mediated FA in children.

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“…Fish is a major component of our human diet, and fish consumption in early childhood might be beneficial for the prevention of allergies 12,13 . Nevertheless, fish is also one of the most common food allergens.…”

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confidence: 99%

Pathogenesis of asthma and characterization of fish allergens

Eigenmann

2020

Pediatric Allergy Immunology

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The role of fish intake on asthma in children: A meta‐analysis of observational studies

Cited by 63 publications

References 59 publications

Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial

Nutrition and Avoidance Diets in Children With Food Allergy

Pathogenesis of asthma and characterization of fish allergens

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