The Role of Fine Particles (PM 2.5) in the Genesis of Atherosclerosis and Myocardial Damage: Emphasis on Clinical and Epidemiological Data, and Pathophysiological Mechanisms

Chaulin, Aleksey M.; Сергеев, А. К.

doi:10.14740/cr1366

Cited by 13 publications

(9 citation statements)

References 136 publications

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“…Taking into account the fact that myocardial hypertrophy is associated with cardiac troponin levels in healthy individuals [ 13 , 84 , 85 , 86 , 87 , 88 ], and in men the myocardial mass (physiological hypertrophy) is bigger than in women [ 56 , 61 ], the metabolism and renewal of cardiomyocytes can also be considered as a possible mechanism that explains the gender-based variations in the serum levels of cardiac troponins. This mechanism can also explain the gender-based differences in CK and CK–MB levels demonstrated in clinical studies [ 89 , 90 , 91 , 92 , 93 , 94 , 95 ].…”

Section: Possible Mechanisms For the Formation Of Gender Specificitie...mentioning

confidence: 92%

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Chaulin

2023

Life

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Cardiac troponins T and I are the main (most sensitive and specific) laboratory indicators of myocardial cell damage. A combination of laboratory signs of myocardial cell damage (elevated levels of cardiac troponins T and I) with clinical (severe chest pain spreading to the left side of the human body) and functional (rise or depression of the ST segment, negative T wave or emergence of the Q wave according to electrocardiography and/or decrease in the contractility of myocardial areas exposed to ischemia according to echocardiography) signs of myocardial ischemia is indicative of the ischemic damage to cardiomyocytes, which is characteristic of the development of acute coronary syndrome (ACS). Today, with early diagnostic algorithms for ACS, doctors rely on the threshold levels of cardiac troponins (99th percentile) and on the dynamic changes in the serum levels over several hours (one, two, or three) from the moment of admission to the emergency department. That said, some recently approved highly sensitive methods for determining troponins T and I show variations in 99th percentile reference levels, depending on gender. To date, there are conflicting data on the role of gender specificities in the serum levels of cardiac troponins T and I in the diagnostics of ACS, and the specific mechanisms for the formation of gender differences in the serum levels of cardiac troponins T and I are unknown. The purpose of this article is to analyze the role of gender specificities in cardiac troponins T and I in the diagnostics of ACS, and to suggest the most likely mechanisms for the formation of differences in the serum levels of cardiac troponins in men and women.

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Section: Possible Mechanisms For the Formation Of Gender Specificitie...mentioning

confidence: 92%

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Chaulin

2023

Life

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“…In patients revealing a 1-SD decrease in flow-mediated dilatation or index reactive hyperemia, a duplication of risk of cardiovascular events in patients with cardiovascular disease (CVD) is markedly superimposed [9][10][11]. These considerations support the determinant role that endothelial function exerts in peripheral vascular circulation that could predict future cardiovascular events, to the point of a potential predictor of future cardiovascular events [9].…”

Section: Introductionmentioning

confidence: 97%

“…Endothelial dysfunction, when detected by impaired brachial artery flowmediated dilatation or digital reactive hyperemia index in peripheral arterial tonometry, may be the marker of future cardiovascular events in patients with coronary artery disease [6][7][8]. In patients revealing a 1-SD decrease in flow-mediated dilatation or index reactive hyperemia, a duplication of risk of cardiovascular events in patients with cardiovascular disease (CVD) is markedly superimposed [9][10][11]. These considerations support the determinant role that endothelial function exerts in peripheral vascular circulation that could predict future cardiovascular events, to the point of a potential predictor of future cardiovascular events [9].…”

Section: Introductionmentioning

confidence: 99%

Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review

Nappi¹,

Singh²

2023

Preprint

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Endothelial integrity plays a major role in homeostasis and is responsive to the numerous endogenous factors released. While its functional role in vascular tone is well described, its role in the pathophysiology of cardiovascular disease is of interest as a potential therapeutic target. We performed a systematic review to provide an overview of new therapeutic and diagnostic targets for the treatment of coronary artery disease related to endothelial dysfunction. Databases of PubMed, Ovid’s version of MEDLINE, and EMBASE were interrogated with appropriate search terms. 28 studies met inclusion criteria and were included in the final systematic review. We identified inflammation, pulmonary hypertension, diabetes mellitus and Fabry disease as pathophysiological mechanisms and explored the therapeutic options related to these conditions including medications such as Canakinumab. Endothelial dysfunction has a key role in several different pathophysiological processes which can be targeted for therapeutic options. Ongoing research should be targeted at making the transition to clinical practice. Further research is also needed on understanding the amelioration of endothelial dysfunction with the use of cardiovascular medications.

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“…Endothelial dysfunction, when detected by impaired brachial artery flow-mediated dilatation or digital reactive hyperemia index in peripheral arterial tonometry, may be the marker of prospective cardiovascular events in patients with coronary artery disease [ 6 , 7 , 8 ]. In patients revealing a 1-SD decrease in flow-mediated dilatation or index reactive hyperemia, a duplication of risk of cardiovascular events in patients with cardiovascular disease (CVD) is markedly superimposed [ 9 , 10 , 11 ]. These considerations support the determinant role that endothelial function exerts in peripheral vascular circulation that could forecast future cardiovascular events, to the point of being a potential predictor of future cardiovascular events [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review

Nappi

Singh

2023

Metabolites

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Endothelial integrity plays a major role in homeostasis and is responsive to the numerous endogenous factors released. While its functional role in vascular tone is well described, its role in the pathophysiology of cardiovascular disease is of interest as a potential therapeutic target. We performed a systematic review to provide an overview of new therapeutic and diagnostic targets for the treatment of coronary artery disease related to endothelial dysfunction. Databases of PubMed, Ovid’s version of MEDLINE, and EMBASE were interrogated with appropriate search terms. Inclusion criteria have been met by 28 studies that were included in the final systematic review. We identified inflammation, pulmonary hypertension, diabetes mellitus and Fabry disease as pathophysiological mechanisms and explored the therapeutic options related to these conditions including medications such as Canakinumab. Endothelial dysfunction has a key role in several different pathophysiological processes which can be targeted for therapeutic options. Ongoing research should be targeted at making the transition to clinical practice. Further research is also needed on understanding the amelioration of endothelial dysfunction with the use of cardiovascular medications.

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The Role of Fine Particles (PM 2.5) in the Genesis of Atherosclerosis and Myocardial Damage: Emphasis on Clinical and Epidemiological Data, and Pathophysiological Mechanisms

Cited by 13 publications

References 136 publications

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Gender Specificities of Cardiac Troponin Serum Levels: From Formation Mechanisms to the Diagnostic Role in Case of Acute Coronary Syndrome

Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review

Distinctive Signs of Disease as Deterrents for the Endothelial Function: A Systematic Review

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