The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls

Dostálová, Lucie; Kalfeřt, David; Jechova, Alzbeta; Koucký, Vladimír; Novák, S; Kuchař, Martin; Zábrodský, Michal; Kodetová, Daniela; Ludvíková, Marie; Kholová, Ivana; Plzák, Jan

doi:10.1007/s00405-020-05868-1

Cited by 26 publications

(23 citation statements)

References 34 publications

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“…Tumors of the salivary gland are relatively rare, constituting a mere 5.0% of all head and neck tumors. Parotid gland tumors account for approximately 80.0% of all salivary gland tumors, most of which (75.0–80.0%) are benign ( 1 ). Pleomorphic adenomas (PA) are the most common tumor of all parotid gland tumors, which are also benign mixed tumors accounting for approximately 60.0% of all parotid tumors.…”

Section: Introductionmentioning

confidence: 99%

Comparative Study of Qualitative and Quantitative Analyses of Contrast-Enhanced Ultrasound and the Diagnostic Value of B-Mode and Color Doppler for Common Benign Tumors in the Parotid Gland

Yan

Chen

et al. 2021

Front. Oncol.

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PurposeTo preliminarily identify three common benign parotid gland tumors: pleomorphic adenomas (PA), Warthin tumors (WT), and basal cell adenomas (BCA) by qualitative and quantitative analyses using contrast-enhanced ultrasound (CEUS).MethodsPreoperative images of parotid gland masses were analyzed, including 129 cases of ultrasonography (US) and color Doppler sonography (CDS) and 110 cases of qualitative and quantitative CEUS. The diagnosis was confirmed by postsurgical pathology outcomes.ResultsPA presented low and heterogeneous enhancement and echo-free area, whereas most WT and BCA presented with high and relatively homogeneous enhancement. Compared with WT and BCA groups, a “slow in” pattern was more common in the PA group and a “slow out” pattern was more frequently noted in the WT group than in the PA and BCA groups. The unique features of qualitative CEUS in the PA group enable distinguishing PA from the 2 other groups. The further distinction among the groups was made based on quantitative parameters of time-intensity curves (TICs), which revealed that the mean peak intensity (PI), mean transit time (MTT), the area under the curve (AUC), and time from peak to one half (HT) exhibited significant differences. ROC analysis was next applied to determine the optimal cutoff points to predict the diagnostic tendency among the groups. When the rising slope (RS) was >2.145, the possibility of BCA was greater than WT.ConclusionsCEUS ultrasound is of significant value in the differential diagnosis of the 3 common benign parotid gland masses.

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Section: Introductionmentioning

confidence: 99%

Comparative Study of Qualitative and Quantitative Analyses of Contrast-Enhanced Ultrasound and the Diagnostic Value of B-Mode and Color Doppler for Common Benign Tumors in the Parotid Gland

Yan

Chen

et al. 2021

Front. Oncol.

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“…According to previous reports, ne needle aspiration biopsy showed a sensitivity and a speci city of 41.7-92.8% and 93.9-98.5%, respectively [45][46] [47]. Whether intraoperative frozen sections should be performed to obtain more pathological information is need to be studied further.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive Treatment for Major Salivary Gland Carcinoma Based on Intensity-Modulated Radiotherapy with or without Radical Surgery

Qiu

Zheng

Lin

et al. 2021

Preprint

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Background The present study aimed to determine a treatment strategy and Intensity-Modulated Radiotherapy (IMRT) target volume for major salivary gland carcinoma (SGC). Methods Patients with SGC treated at our cancer center between August 2009 and August 2020 were retrospectively reviewed. Results The following primary tumor sites were identified: parotid gland in 61 (69.3%) patients, submandibular gland in 21 (23.9%) patients, and sublingual gland in six (6.8%) patients. Lymphoepithelial carcinoma (LEC) was the most common tumor subtype that accounted for 23.9% of cases. A total of 80 (90.9%) patients received radical surgery combined with postoperative radiotherapy. Eight patients (9.1%) received definitive radiotherapy: six patients with advanced-stage disease received induction chemotherapy (IC) combined with concurrent chemoradiotherapy (CCRT), and two patients with early-stage disease received CCRT. Complete response was observed in these eight patients after treatment completion. The median follow-up time of all patients was 42 months (range: 4–129 months). No patient developed local recurrence. The 5-year overall survival, regional failure-free survival, distant metastasis-free survival, and progression-free survival probabilities were 84.1%, 95.6%, 75.3%, and 75.7%, respectively. Distant metastasis was observed in 18 (20.5%) patients, followed by regional 2 (2.3%) recurrence. Permanent facial nerve injury was confirmed in 31 patients by follow-up. None of the patients experienced facial nerve paralysis in the definitive radiotherapy group. Conclusions LECs may be sensitive to chemoradiotherapy, which may achieve a radical effect and avoid unnecessary surgical injury. IC combined with CCRT is expected to become a new treatment strategy for advanced LECs. The IMRT target volume delineation according to the surgical principles may be a more promising method with good clinical efficacy that is worthy of further study.

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“…We thank Tretiakow et al for their interest in our article [1,2]. In our commentary below, we shall try to clarify our point of view with regard to the remarks that have been made [2].…”

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confidence: 91%

Reply to letter to the editor “The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls”

Dostálová

Kalfeřt

Jechova

et al. 2020

Eur Arch Otorhinolaryngol

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The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls

Cited by 26 publications

References 34 publications

Comparative Study of Qualitative and Quantitative Analyses of Contrast-Enhanced Ultrasound and the Diagnostic Value of B-Mode and Color Doppler for Common Benign Tumors in the Parotid Gland

Comparative Study of Qualitative and Quantitative Analyses of Contrast-Enhanced Ultrasound and the Diagnostic Value of B-Mode and Color Doppler for Common Benign Tumors in the Parotid Gland

Comprehensive Treatment for Major Salivary Gland Carcinoma Based on Intensity-Modulated Radiotherapy with or without Radical Surgery

Reply to letter to the editor “The role of fine-needle aspiration biopsy (FNAB) in the diagnostic management of parotid gland masses with emphasis on potential pitfalls”

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