The role of Fibroscan in predicting the presence of varices in patients with cirrhosis

Al–Hamoudi, Waleed; Abdelrahman, Awny A.; Helmy, Ahmed; Anil, Shirin; Khamis, Nehal; Arafah, Maha; Alswat, Khalid; Suwefy, Youssef M.; Sanai, Faisal M.; Faleh, Faleh Al; Abdo, Ayman A.

doi:10.1097/meg.0000000000000432

Cited by 6 publications

(2 citation statements)

References 24 publications

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“…However, the cutoff values that have been used again exhibit considerable variability, ranging between 16.6 and 38.2 kPa [ 20 , 21 ]. Applying the cutoff value (<20 kPa) proposed by BAVENO VI to elastography (as a single test) for the detection of large varices in patients with viral hepatitis yielded a sensitivity of approximately 83% and a negative predictive value of 66.7%, not sufficient to rule out varices [ 24 ].…”

Section: Resultsmentioning

confidence: 99%

Νon-invasive screening for esophageal varices in patients with liver cirrhosis

Karatzas¹,

Konstantakis

Αγγελετοπούλου³

et al. 2018

aog

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Esophageal varices are one of the main complications of liver cirrhosis. Upper gastrointestinal endoscopy is the gold standard for the detection of esophageal varices. Many less invasive methods for screening of varices have been investigated and the most recent Baveno VI guidelines suggest that endoscopy is not necessary in patients with liver stiffness <20 kPa and platelets >150,000/μL. A critical review of the literature was performed concerning non-invasive or minimally invasive methods of screening for esophageal varices. Liver and spleen elastography, imaging methods including computed tomography, magnetic resonance imaging and ultrasound, laboratory tests and capsule endoscopy are discussed. The accuracy of each method, and its advantages and limitations compared to endoscopy are analyzed. There are data to support the Baveno VI guidelines, but there is still a lack of large prospective studies and low specificity has been reported for the liver stiffness and platelet count combination. Spleen elastography has shown promising results, as there are data to support its superiority to liver elastography, but it needs further assessment. Computed tomography has shown high diagnostic accuracy and can be part of the diagnostic work up of cirrhotic patients in the future, including screening for varices.

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Section: Resultsmentioning

confidence: 99%

Νon-invasive screening for esophageal varices in patients with liver cirrhosis

Karatzas¹,

Konstantakis

Αγγελετοπούλου³

et al. 2018

aog

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“…The rates of hospitalization, over all mortality and rebleeding rate secondary to esophageal varices have decreased to 14.2%, 33.5%, and 29%, respectively, due to recent advancements in medical science in the diagnosis and treatment of esophageal varices [12]. Treatment with β-blockers can diminish the probability of bleeding by 50% in patients with medium and large varices by reducing the venous pressure [13].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Multidetector Computed Tomography in Detection of Esophageal Varices

Hassan¹,

Husen²,

Abbasi³

et al. 2019

Cureus

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ObjectiveTo determine the diagnostic accuracy of multidetector computed tomography (MDCT) in the detection of esophageal varices by taking endoscopy as the reference standard.Materials and methodsThis was a cross-sectional prospective study conducted at the Department of Radiology, Aga Khan University Hospital, (AKUH) Karachi, for the duration of 12 months from August 1, 2014 to July 31, 2015. One hundred ninety-six patients with a suspicion of chronic liver disease/cirrhosis undergoing 64 slice MDCT were enrolled in our study and underwent computed tomography (CT) scanning in the Department of Radiology at AKUH. Biphasic CT was performed with images obtained during the hepatic arterial phase (30-second delay) and the portal venous phase (65-second delay) after the intravenous (IV) injection of 120 mL of nonionic contrast material at a rate of 3.5 mL/s. The presence of esophageal varices was evaluated on MDCT with endoscopy as gold standard. The sensitivity, specificity, negative predictive value and positive predictive value, and accuracy of MDCT were assessed against the gold standard.ResultsOur results yielded an MDCT sensitivity of 98.96%, specificity of 100%, positive predictive value (PPV) of 100%, negative predictive value (NPV) of 66.67%, and diagnostic accuracy of 98.97% for esophageal varices in chronic liver disease (CLD) patients.ConclusionThe rate of detection of esophageal varices in patients with chronic liver disease on MDCT in our country is comparable to the international data and we advocate that MDCT should be used as a screening tool in patients with chronic liver disease to exclude esophageal varices.

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Prediction for Improvement of Liver Function after Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Varices to Manage Portosystemic Shunt Syndrome

Yamamoto

Nishida

Morikawa

et al. 2016

Journal of Vascular and Interventional Radiology

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The role of Fibroscan in predicting the presence of varices in patients with cirrhosis

Abstract: Fibroscan might be useful in predicting the presence of EV in patients with cirrhosis with a viral etiology. However, endoscopy remains the gold standard for EV screening.

Cited by 6 publications

References 24 publications

Νon-invasive screening for esophageal varices in patients with liver cirrhosis

Νon-invasive screening for esophageal varices in patients with liver cirrhosis

Diagnostic Accuracy of Multidetector Computed Tomography in Detection of Esophageal Varices

Prediction for Improvement of Liver Function after Balloon-Occluded Retrograde Transvenous Obliteration for Gastric Varices to Manage Portosystemic Shunt Syndrome

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