The role of fibroblast growth factor 18 in cancers: functions and signaling pathways

Abstract

Fibroblast growth factor 18(FGF18) is a member of the fibroblast growth factor family (FGFs). FGF18 is a class of bioactive substances that can conduct biological signals, regulate cell growth, participate in tissue repair and other functions, and can promote the occurrence and development of different types of malignant tumors through various mechanisms. In this review, we focus on recent studies of FGF18 in the diagnosis, treatment, and prognosis of tumors in digestive, reproductive, urinary, respiratory, motor, and pediatric systems. These findings suggest that FGF18 may play an increasingly important role in the clinical evaluation of these malignancies. Overall, FGF18 can function as an important oncogene at different gene and protein levels, and can be used as a potential new therapeutic target and prognostic biomarker for these tumors.

A high-sensitivity ELISA for detection of human FGF18 in culture supernatants from tumor cell lines

“…No reuse allowed without permission. cancers, including colorectal, ovarian, and gastric cancers [9]. Sonvilla et al showed that FGF18 expression is elevated in colorectal tumors and promotes tumor cell growth by enhancing the proliferation of colon-associated fibroblasts as well as tumor cells and neovascularization [10].…”