The role of fibrinogen and fibrinolysis in peripheral arterial disease

Paraskevas, Kosmas I.; Baker, DM; Vrentzos, G.; Mikhailidis, Dimitri P.

doi:10.1016/j.thromres.2007.06.003

Cited by 50 publications

(49 citation statements)

References 125 publications

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“…However, there is a paucity of information about the impact of smoking cessation on fibrin clot properties. A few studies refer to the influence of current smoking rather than on smoking cessation [3,5,7]. To assess fibrin clot structure and function, we adopted the method of fibrin clot formation from citrated plasma.…”

Section: Discussionmentioning

confidence: 99%

“…The benefits of smoking cessation are not dependent on age, sex and hypertensions, although the decrease in the risk appears to be dependent on the duration of smoking abstinence and the number of cigarettes smoked per day [3]. Cigarette smoking is the strongest, dose-dependent environmental factor, determining plasma fibrinogen concentration, plasma clot permeability and susceptibility to lysis [4,5].…”

Section: Introductionmentioning

confidence: 99%

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Beneficial effect of cigarette smoking cessation on fibrin clot properties

Stępień

Miszalski−Jamka

Kapusta

et al. 2011

J Thromb Thrombolysis

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To examine the associations between cigarette smoking and preferable clot properties. Plasma fibrin clots from 21 randomly selected current smokers (n = 7), former smokers (n = 7) and non-smokers (n = 7) were analyzed, using scanning electron microscopy (SEM). With the use of the turbidimetric clotting and lysis assay in plasma, the maximum absorbance (MaxAbs(C), MaxAbs(L)) was measured and lysis time (Lys(50%)) was calculated. Smoking cessation significantly influenced fibrin fiber branching and density. Median fiber diameter was not changed. Lys(50%) was the highest in current smokers and was reduced in former smokers to the non-smoker level (2120 ± 385 versus 1771 ± 122 and 1724 ± 272 s; P = 0.04). Smoking cessation improves fibrin clot architecture which results in the lesser resistance to lysis.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Beneficial effect of cigarette smoking cessation on fibrin clot properties

Stępień

Miszalski−Jamka

Kapusta

et al. 2011

J Thromb Thrombolysis

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“…Meanwhile, BMI, eGFR and the serum levels of albumin, total cholesterol, RLP cholesterol and triglycerides were higher in the patients treated with statins, whereas the serum levels of homocysteine, D-dimer, TAT and PIC were lower in these patients. The prevalence of aspirin, clopido- high-sensitivity C-reactive protein, Total-C: total cholesterol, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein cholesterol, RLP-C: remnant-like particle cholesterol, TAT: thrombin-antithrombin complex, PIC: plasmin-2 plasmin inhibitor complex, BNP: brain natriuretic peptide, ACE: angiotensin-converting enzyme, ARB: angiotensin receptor blocker tion, the fibrinogen level is particularly associated with the severity and potential for the further development of PAD 26) and functions as an independent risk factor for CAD 25) . Hyperhomocysteinemia is an independent risk factor for atherosclerosis and a stronger risk factor for PAD than for CAD 16,17) , with an association with death or severe vascular events in patients with PAD 27) .…”

Section: Discussionmentioning

confidence: 99%

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Kumakura

Fujita

Kanai

et al. 2015

JAT

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Aim:The goal of the study was to investigate the relationships between coronary artery disease (CAD) and risk factors, including the serum levels of high-sensitivity C-reactive protein (hs-CRP), lipoprotein(a) (Lp(a)) and homocysteine, in Japanese patients with peripheral arterial disease (PAD). Methods: Coronary angiography was performed in 451 patients with PAD, among whom the prevalence and clinical characteristics of CAD were analyzed. A multiple logistic analysis was used to evaluate the relationships between CAD and the risk factors. The relationships between the severity of coronary arterial lesions and the risk factors were evaluated using multiple regression analysis. Results: The prevalence of CAD (≥ 70% luminal diameter narrowing or a history of CAD) and coronary artery stenosis (≥ 50%) was 55.9% and 74.1%, respectively, and the rate of CAD (≥ 70%) with single-, double-and triple-vessel disease was 25.9%, 13.5% and 10.6%, respectively. The prevalence of diabetes was higher among the patients with CAD than among those without. The serum levels of hs-CRP, Lp(a), and homocysteine were higher in the patients with CAD, whereas the estimated glomerular filtration rates and HDL-cholesterol levels were lower in these patients. According to the multiple logistic analysis, CAD was related to diabetes (hazard ratio [

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“…Several studies have reported low t-PA and, more frequently, high PAI-1 values in PAD patients [172]. Impaired fibrinolysis appears to play a role in the future development of PAD in patients with type 2 DM [173].…”

Section: Tissue Plasminogen Activator (Tpa) Plasminogen Activator Inmentioning

confidence: 99%

Associations of Thrombotic-Hemostatic Factors with Cardiovascular Disease~!2009-10-29~!2009-12-22~!2010-04-08~!

Lioudaki¹,

Ganotakis²

2012

TOCCHEMJ

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Cardiovascular disease (CVD) remains a leading cause of global morbidity and mortality despite identification of major cardiovascular (CV) risk factors and risk reduction via appropriate interventions. During the last years several markers have been studied as potential predictors of CV events. Hemostatic and thrombotic factors such as fibrinogen, homocysteine, factor VII, von Willebrand, tissue plasminogen activator, plasminogen activator inhibitor -1, D-dimer and lipoprotein ( ) have been found to be closely related to CVD. Many epidemiological studies have indicated that raised levels of these factors are associated with higher incidence of CVD, while some others have yielded conflicting results. As a consequence, it remains obscure whether they contribute to prediction of future CV events on top of conventional risk factors. Although data suggest that most of them are somehow implicated in CVD pathophysiology, it is not clearly defined yet whether treatment of abnormal levels leads to CV risk reduction. As a result measurement and treatment of these factors are justified only in exceptional cases. Further investigation is required in order to conclude whether and which of these factors may claim a position in everyday clinical practice.

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The role of fibrinogen and fibrinolysis in peripheral arterial disease

Cited by 50 publications

References 125 publications

Beneficial effect of cigarette smoking cessation on fibrin clot properties

Beneficial effect of cigarette smoking cessation on fibrin clot properties

High-sensitivity C-reactive Protein, Lipoprotein(a) and Homocysteine are Risk Factors for Coronary Artery Disease in Japanese Patients with Peripheral Arterial Disease

Associations of Thrombotic-Hemostatic Factors with Cardiovascular Disease~!2009-10-29~!2009-12-22~!2010-04-08~!

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