The role of fiberoptic bronchoscopy for diagnosis of pulmonary tuberculosis in patients at risk for AIDS

β-Chemokines Are Induced byMycobacterium tuberculosisand Inhibit Its Growth

“…These findings are particularly significant since we also found that AM from HIV-infected individuals produced significantly less MIP-1␤ and RANTES in response to M. tuberculosis than control AM. We speculate that the relative ability to produce these ␤-CK may constitute a host susceptibility factor or could play a role in the defective granuloma formation seen in HIV-infected individuals (12,24,25). There are several potential mechanisms by which ␤-CK may influence the intracellular growth of M. tuberculosis.…”

“…The ability of CK to attract and activate T cells and monocytes suggests that CK may have a role in modulating immune responses to M. tuberculosis infection. Poor granuloma formation is a characteristic finding in M. tuberculosis infection in advanced HIV type 1 disease (12,24,25) and suggests that ␤-CK production may be deficient. Virulence or host-associated differences in M. tuberculosis-induced CK production may also contribute to failure to contain the infection.…”