The role of FHL1 in tumors

Zeng, Qun; Jiang, Tingting

doi:10.1016/j.gene.2024.148347

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2024

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“…Oncogenes, tumor suppressor gene and DNA repair genes play pivotal roles in tumorigenesis, which is the process wherein normal cells undergo malignant transformation ( 5 – 7 ). Oncogenes, when activated or mutated, harbor the potential to instigate cancer by fostering uncontrolled cellular proliferation and aberrant signaling cascades ( 5 ). Conversely, tumor suppressor genes act as guardians of cellular homeostasis, curtailing aberrant growth and facilitating DNA repair mechanisms ( 6 ).…”

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confidence: 99%

Role of LMO7 in cancer (Review)

Zeng,

Jiang,

Wang

2024

Oncol Rep

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Cancer constitutes a multifaceted ailment characterized by the dysregulation of numerous genes and pathways. Among these, LIM domain only 7 (LMO7) has emerged as a significant player in various cancer types, garnering substantial attention for its involvement in tumorigenesis and cancer progression. This review endeavors to furnish a comprehensive discourse on the functional intricacies and mechanisms of LMO7 in cancer, with a particular emphasis on its potential as both a therapeutic target and prognostic indicator. It delves into the molecular attributes of LMO7, its implications in cancer etiology and the underlying mechanisms propelling its oncogenic properties. Furthermore, it underscores the extant challenges and forthcoming prospects in targeting LMO7 for combating cancer.

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