The role of female hormones on lung function in chronic lung diseases

Tam, Anthony Raymond; Morrish, Don; Wadsworth, Samuel J.; Dorscheid, Delbert R.; Man, SF Paul; Sin, Don D.

doi:10.1186/1472-6874-11-24

Cited by 168 publications

(146 citation statements)

References 82 publications

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“…However, there are certain findings on gender differences in pulmonary diseases discussing an involvement of female hormones. 27 Among chronic obstructive pulmonary disease patients, a beneficial effect of inhaled corticosteroids was especially noticeable in women 28 and estrogen receptor-alpha was identified as a potential drug target preventing from lung inflammation. 29 Even changes in exhaled NO concentrations due to cyclic estrogen and progesterone changes were reported.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans after allogeneic hematopoietic SCT: further insight—new perspectives?

Ditschkowski

Elmaagacli

Koldehoff

et al. 2013

Bone Marrow Transplant

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Bronchiolitis obliterans (BO) is a late non-infectious pulmonary complication after allogeneic hematopoietic SCT. Among 982 patients after myeloablative hematopoietic SCT between January 2000 and October 2010, 68 were diagnosed with BO according to NIH criteria. The median onset of BO was 18 months post transplant, 5-year cumulative incidence was 5.8% and 5-year mortality 41%. BO prevalence rate was 10% among all long-term surviving hematopoietic SCT recipients and 12% among chronic GVHDpatients. Chronic GVHD, peripheral SCT and ABO blood group incompatibility were identified as risk factors associated with BO. IgG levels were significantly decreased at the onset of BO (6.7 g/L ± 0.7, P ¼ 0.001), the mean exhaled NO concentrations were lower in BO-patients than in stem cell recipients without BO (14 p.p.b.±0.9 vs 20 p.p.b.±2.1) or healthy controls (25 p.p.b.±2.4, Po0.001). Hypoxia-inducible factor 1 alpha (HIF-1a) was significantly elevated in BO as compared with healthy controls or GVHD-patients without lung involvement (340 ± 61 vs 127 ± 22 vs 140 ± 32, P ¼ 0.02). Calculated 5-year survival was superior in female than in male BO-patients (86 vs 45%, P ¼ 0.04). These results emphasize the relevance of BO as serious late complication with substantial mortality and point to essential pathophysiological changes due to regulatory responses to hypoxia. Keywords: bronchiolitis obliterans; nitric oxide; allogeneic; GVHD; HIF-1a; SCT INTRODUCTION Allogeneic hematopoietic SCT has been shown to provide longterm disease-free survival for otherwise fatal malignant or nonmalignant hematological disorders. With increasing survival rates due to toxicity reduced hematopoietic SCT methods, advanced GVHD-management and improved anti-infectious therapy and prophylaxis, a distinct increment in late transplant related complications can be observed. Pulmonary complications develop in 30-60% of allogeneic hematopoietic SCT recipients and are considered as a major cause of morbidity and mortality. 1,2 Late-onset non-infectious pulmonary complications 3 beginning 3 months after transplantation with an incidence of 10-15% are considered as life-threatening complications significantly limiting the quality of life. 4,5 Although late-onset non-infectious pulmonary complications classification is rather undefined, the most common categorizations include bronchiolitis obliterans (BO), bronchiolitis obliterans organizing pneumonia and interstitial pneumonia. 6,7 According to the NIH consensus criteria, BO is considered to be the only pulmonary manifestation of chronic GVHD. 8 The reported incidence of BO in allogeneic hematopoietic SCT recipients ranges from 2-10% and mortality rates have been assessed between 13 and 23%. 9,10 BO is prevalent in 2-5.5% of hematopoietic SCT recipients and in up to 14% of hematopoietic SCT recipients with chronic GVHD. 11 Patients diagnosed with BO have a 5-year survival rate of only 45% vs 75% in patients without BO. 9 Advanced disease stages at transplantation, preceding GVHD, older donor and recipient age, M...

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Section: Discussionmentioning

confidence: 99%

Bronchiolitis obliterans after allogeneic hematopoietic SCT: further insight—new perspectives?

Ditschkowski

Elmaagacli

Koldehoff

et al. 2013

Bone Marrow Transplant

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“…Sex hormones also contribute to this phenomenon. Female sex hormones such as estrogen and 11 showed that female hormones increase the airway inflammation when exposed to the allergen, and the severity also fluctuates over the course of menstrual cycles. Estradiol has an important role to up-regulate the pro inflammatory cytokine and down-regulate the anti-inflammatory cytokine.…”

Section: Discussionmentioning

confidence: 99%

Characteristics of Asthma Patients Seeking Care at West Java’s Top Referral Hospital, Indonesia

Yudistira¹,

Pranggono²,

Tjandrawati³

et al. 2017

amj

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Background: The increasing incidence of asthma in many countries in recent decades makes asthma a global health problem. The aim of the study was to determine the characteristics of asthma patients at the Respirology Outpatient Clinic of Dr. Hasan Sadikin General Hospital as West Java's Top referral hospital. Methods:The study used a cross-sectional design. The study population was the medical record data of asthma patients at the Respirology Outpatient Clinic during June 2012-June 2013. There were 1,591 patient's medical records at the Respirology Outpatient Clinic of Dr. Hasan Sadikin General Hospital Bandung in that period and 140 medical records were diagnosed with asthma. Seventy medical records were excluded because of inadequate data and 70 medical records were the sample of this study. The collected data were presented using percentage. Results: Seventy percent of the cases were female. From these cases 34% of patients were aged 51-60 years. The partially controlled type was the most frequent type of asthma (62%). The most common sign and symptom was shortness of breath (86%). The most common drug used was Beta 2 agonist drugs (90%). Conclusions:The characteristic of asthma is that the patients are mostly female. Mostly the patients were in the age range of 51-60 years. The partially controlled type is the most frequent type of asthma. Shortness of breath is the most common clinical manifestation in asthma. Beta 2 agonist is the most used drug for asthma. [AMJ.2017;4(1):78-82]

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“…A menopauza előtt nagyrészt szisztémásan, de a perifériás szöveteken és az agyban is termelődő 2-hidroxiösztrogének hormonális aktivitása sokkal gyengébb, ugyanakkor a tumorsejtek proliferációját és az angiogenezist gátolják (3. ábra) [35]. A 2-hidroxi-ösztrogének kialakításáért a CYP1A1 enzim a felelős, ezek az ER-hez nem kötődnek, ezáltal kevésbé reaktívak [36,37]. Jelenleg is több klinikai vizsgálat zajlik, ahol a 2-metoxiösztradiol antiangiogenetikus, valamint antivascularisatiós hatását értékelik [38].…”

Section: Az öSztrogénmetabolitok Biológiai Hatásaiunclassified

“…A GPER lehet felelős a nem kanonikus ERmediált útvonal aktivitásáért. Emellett emelkedett 17β-HSD1-, valamint aromatázaktivitást találtak, amelyek részt vesznek az aktív ösztrogének lokális szintézi-sében [36,37].…”

Section: Az öSztrogénmetabolom Szerepe Tüdőtumorokban éS Copd Kialakuunclassified

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

Kovács

Vásárhelyi

Mészáros³

et al. 2017

Orvosi Hetilap

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Az ösztrogénhormonok fiziológiai szerepe sok tekintetben ismert. Meglehetősen kevés információ áll azonban rendelkezésre az ösztron és az ösztradiol lebontása során képződő vegyületek szerepéről a különböző, ösztrogénhatással összefüggésbe hozott kórképekben. A kutatások intenzív érdeklődésének középpontjában jelenleg a két ösztrogén-hormon mellett tizenhárom extragonadális metabolit áll. A képződő metabolitok protektív vagy éppen proinflammatorikus és/vagy proonkogén hatással rendelkeznek. A szisztémás keringésben mért metabolitszintek nem mutatnak összefüggést a lokálisan megjelenő metabolitokéval, ennek a jövőben diagnosztikai jelentősége lehet. A jelen tanulmány célja a perifériás szövetekben az extragonadális metabolommal kapcsolatos irodalmi források átfogó áttekintése, valamint felhívni a figyelmet a perifériás szövetek ösztrogénhomeosztázisának szerepére, az ösztrogénmetabolom igazolt, valamint a klasszikus hormonhatásoktól eltérő biológiai aktivitására, egyes kórfolyamatokban azonosított klinikai jelentőségére. Ezek az ismeretek a lokálisan determinált kórfolyamatok megértését, korai diagnosztikáját a későbbiekben a metabolomika eszköztárával jelentősen segíthetik. Orv Hetil. 2017; 158(24): 929-937. Kulcsszavak: ösztrogénmetabolom, perifériás szövetek, emlőkarcinóma, HPLC-MS/MS The biological and clinical relevance of estrogen metabolomeConsiderable knowledge has been gathered on the physiological role of estrogens. However, fairly little information is available on the role of compounds produced in the breakdown process of estrone and estradiol wich may play a role in various diseases associated with estrogen impact. To date, approximately 15 extragonadal estrogen-related compounds have been identified. These metabolites may exert protective, or, instead, pro-inflammatory and/or prooncogenic activity in a tissue-specific manner. Systemic and local estrogen metabolite levels are not necesserily correlated, which may promote the diagnostic significance of the locally produced estrogen metabolites in the future. The aim of the present study is a bibliographic review of the extragonadal metabolome in peripheral tissues, and to highlight the role of the peripheral tissue homeostasis of estrogens as well as the non-hormonal biological activity and clinical significance of the estrogen metabolome.

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The role of female hormones on lung function in chronic lung diseases

Cited by 168 publications

References 82 publications

Bronchiolitis obliterans after allogeneic hematopoietic SCT: further insight—new perspectives?

Bronchiolitis obliterans after allogeneic hematopoietic SCT: further insight—new perspectives?

Characteristics of Asthma Patients Seeking Care at West Java’s Top Referral Hospital, Indonesia

Az ösztrogénmetabolom biológiai és klinikai jelentősége lokális folyamatokban

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