The role of Fe(II) in the increased medicinal potency of curcumin analyzed by electrochemical methods

Monooxovanadium(V) 2-phenylphenoxides: synthesis, characterization, and antimicrobial potential

“…The antifungal activity of the complexes is less than standard fungicides, namely, cycloheximide, carbendazim, and fluconazole (MIC values 53.12 mg mL À1 ). A comparison of the results of biological activity of the monooxovanadium(V) complexes with that of other reports [45][46][47][48][49][50][51][52][53][54][55] revealed the effectiveness of newly synthesized vanadium complexes as antimicrobial agents.…”

“…The biological activity of several vanadium complexes has been reported [45][46][47][48][49][50][51][52][53][54][55]. The ligand, 2-phenylphenol, and the newly synthesized monooxovanadium(V) complexes All the complexes possess more activity against S. aureus, with an MIC of 6.25-12.5 mg mL À1 , than the MIC shown for E. coli at 12.5-25 mg mL À1 .…”

Curcuminoids and Acetylacetone: Iron Complexes as Studied by Electrospray Ionization Mass Spectrometry

“…14 In vitro studies have proved that the curcumin complex with iron(II) has a better anticancer efficiency than the parent drug. 15 Interactions with iron are also strictly linked to the treatment of Alzheimer's disease. Curcumin can regulate the generation of reactive oxygen species by blocking the Fenton and Haber-Weiss reactions.…”

Demethoxycurcumin-Metal Complexes: Fragmentation and Comparison with Curcumin-Metal Complexes, as Studied by ESI-MS/MS

“…These two curcuminoids, and especially dCurc, have also been studied in terms of their biological and pharmacological properties [6][7][8][9][10][11][12]; sometimes dCurc exhibited better properties than Curc [13][14][15]. Curcuminoids have a -diketone unit; thus they are able to form stable complexes with metal cations, number of Curc-metal complexes have been reported [16][17][18][19][20][21][22][23][24][25] and formation of such complexes may have interesting pharmacological implications [26][27][28][29][30][31][32][33][34][35]. On the other hand, dCurc-metal complexes have not been studied yet.…”

“…Figure 2shows the CID-MS/MS spectra of ions [dCurc + Curc-2H + Fe] + and [dCurc + Curc-2H + Ga] + . It is worth noting that Fe-curcumin complexes may have interesting pharmacological applications[27,34,35].Ion[dCurc + Curc-2H + Fe] + loses organic radicals [dCurc-H] • and [Curc-H] • , producing fragment ions [Curc-H + Fe] + and [dCurc-H + Fe] + , respectively (formally, it is iron reduction Fe 3+ → Fe 2+ ). As clearly indicated in Figure 2(a), the loss of radical [Curc-H] • occurs with higher efficiency than that of radical [dCurc-H] • .…”