“…In chronic human ITP, removal of the spleen can stabilize platelet counts in about 60%-70% of patients, which has been used as indirect evidence that splenic-resident macrophages might be involved in autoantibody-mediated platelet phagocytosis (Biburger et al, 2010;Cines and McMillan, 2005;Mizutani et al, 1992). Moreover, liver-resident macrophages (Kupffer cells) are suggested to be involved in removal of opsonized platelets and do express the relevant activating FcgRIV ( Figure 1B; Coetzee et al, 2000;Heyns et al, 1980;Schmidt and Rasmussen, 1985;Stratton et al, 1989).…”