The role of fascin in carcinogenesis and embryo implantation

Lamptey, Jones; Czika, Armin; Aremu, John Ogooluwa; Pervaz, Sadaf; Adu‐Gyamfi, Enoch Appiah; Otoo, Antonia; Li, Fangfang; Wang, Yingxiong; Ding, Yubin

doi:10.1016/j.yexcr.2021.112885

Cited by 12 publications

(16 citation statements)

References 104 publications

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“…21 Fascin overexpression is observed in various precancerous lesions and oral squamous cell carcinoma (OSCC). 9,12 In our study, we observed that a majority of our cases were strongly positive for fascin in the various subtypes of ameloblastoma.…”

Section: Discussionsupporting

confidence: 54%

“…Fascin, a 55-kDa is a cytoskeleton binding proteins that bundle actin filaments, assists the cell in forming stress fibres (or ruffled borders or micro spikes) and assists cell motility and migration hence it fascin can be used for predicting the aggressive clinical course of a tumor. [7][8][9][10] Usually, in normal adult epithelial cells its fascin expression is low or absent. 11 The gene encoding fascin-1 in humans is located on chromosome 7q22.…”

Section: Introductionmentioning

confidence: 99%

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Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.

et al. 2022

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Background: Various stemness markers (SOX2, OCT4, and NANOG) have been studied in odontogenic cysts and tumors. However, studies on SALL4 having similar properties of stemness has not been documented. Additionally, insight into fascin as a migratory molecule is less explored. In this study, the expression of SALL4 and fascin were evaluated in ameloblastoma, adenomatoid odontogenic tumor (AOT), odontogenic keratocyst (OKC), dentigerous cyst (DC), radicular cyst (RC), and calcifying odontogenic cyst (COC). Methods: Semi-quantitative analysis of fascin and SALL4 immuno-positive cells was done in a total of 40 cases of ameloblastoma (11 plexiform, 12 follicular, 12 unicystic, and 5 desmoplastic) variants, 6 cases of AOT, 15 each of OKC, DC, RC and 5 of COC. Chi-square test was applied to evaluate the association between SALL4 and fascin expression in odontogenic cysts and tumors. Results: Fascin immunopositivity was observed in peripheral ameloblast-like cells, and weak or absent in stellate reticulum-like cells. A moderate to weak immune-reactivity to SALL4 was observed in the cytoplasm of ameloblastoma, epithelial cells of dentigerous and radicular cysts, having a marked inflammatory infiltrate, which is an interesting observation. COC and AOT had negative to weak expressions. No recurrence has been reported. Conclusions: Expression of fascin in ameloblastomas elucidate their role in motility and localized invasion. Its expression in less aggressive lesions like DC, COC, AOT will incite to explore the other functional properties of fascin. SALL4 expression in the cytoplasm of odontogenic cysts and tumors may represent inactive or mutant forms which requires further validation.

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Section: Discussionsupporting

confidence: 54%

Section: Introductionmentioning

confidence: 99%

Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.

et al. 2022

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“…Moreover, silencing IFITM2 expression can reduce TGF-β1-induced EMT, which is verified in terms of gene and protein levels, as well as scratch and transwell experiment. It has been suggested that down-regulation of E-cadherin could activate target genes including IFITM family members and thereafter promote cancer progression [21,22]. In our recent research, we noticed that IFITM2 promoted the growth and metastasis of GC [8].…”

Section: Discussionmentioning

confidence: 81%

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer

liu

Zhou

et al. 2021

Mol Biol Rep

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Background Gastric cancer (GC) is one of the most prevalent malignancy around the world. Primary tumor cells are enabled to invade and migrate into adjacent normal tissues to form secondary tumors. Epithelial-mesenchymal transitions (EMT) plays a pivotal role in facilitating tumor progression. Abundant evidence suggested that the transforming growth factor-β1 (TGF-β1) triggered the process of EMT. Nonetheless, the precise molecular mechanisms underlying EMT requires further elucidation, and there still lacks effective specific therapeutic target. In our recent research, we demonstrated that the interferon (IFN)-induced transmembrane protein 2 (IFITM2) promoted the growth and metastasis of GC. However, it remains unclear whether IFITM2 involves in TGF-β1 mediated EMT in GC. Methods and resultsIn the present research, we investigated the functional role of IFITM2 in EMT process and TGF-β1 signaling pathway in two GC cell lines. We noticed that silencing IFITM2 can effectively inhibit TGF-β1 signaling mediated EMT by regulating down stream small mother against decapentaplegic (SMAD) 2/3 and transcription factors.This finding was further determined in both tumor tissues from GC patients and normal tissues adjacent to cancer. Our data demonstrated the key role of IFITM2 in TGF-β1 signaling and EMT in GC. ConclusionThe findings enriched our understanding of the underlying mechanism in EMT during the progression of GC. In addition, IFITM2 would be a potential target for treating GC and other malignant tumors. KeywordsCancer invasion and metastasis • Epithelial-mesenchymal transitions • Gastric cancer • IFITM2 • Molecular mechanism • TGF-β1 Abbreviations EMT Epithelial-mesenchymal transitions ECM Extracellular matrix GC Gastric cancer GSEA Gene set enrichment analysis IFITM2 Interferon (IFN)-induced transmembrane protein 2 NES Normalized enrichment score SMAD Small mother against decapentaplegic TGF-β1 Transforming growth factor-β1 ZEB1Zinc finger E-box-binding homeobox 1Yonggang Liu and Minyu Zhou-co-first author.

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“…Meanwhile, the review by Lamptey et al. also compiled an analysis of the role of fascin-1 during human embryogenesis ( 35 ). It was found to regulate the epithelial-mesenchymal transition in placental formation and early embryogenesis and to achieve homeostasis ( 35 ).…”

Section: Literature Reviewmentioning

confidence: 99%

“…Other people still have great expectations for future studies of fascin-1 ( 9 , 16 , 21 , 30 – 35 ). Meanwhile, the results suggest that fascin-1 is a promising marker for tumor diagnosis and prognosis ( 9 , 16 , 30 – 32 ), but further studies are still needed to test the therapeutic potential of this protein ( 21 , 31 ).…”

Section: Literature Reviewmentioning

confidence: 99%

The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers

et al. 2022

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Human cancer statistics report that respiratory related cancers such as lung, laryngeal, oral and nasopharyngeal cancers account for a large proportion of tumors, and tumor metastasis remains the major reason for patient death. The metastasis of tumor cells requires actin cytoskeleton remodeling, in which fascin-1 plays an important role. Fascin-1 can cross-link F-actin microfilaments into bundles and form finger-like cell protrusions. Some studies have shown that fascin-1 is overexpressed in human tumors and is associated with tumor growth, migration and invasion. The role of fascin-1 in respiratory related cancers is not very clear. The main purpose of this study was to provide an updated literature review on the role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers. These studies suggested that fascin-1 can serve as an emerging biomarker and potential therapeutic target, and has attracted widespread attention.

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The role of fascin in carcinogenesis and embryo implantation

Cited by 12 publications

References 104 publications

Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.

Expression of Fascin and SALL4 in odontogenic cysts and tumors: an immunohistochemical appraisal.

Interferon-induced transmembrane protein 2 promotes epithelial-mesenchymal transition by activating transforming growth factor-β1/small mother against decapentaplegic 2 signaling in gastric cancer

The role of fascin-1 in the pathogenesis, diagnosis and management of respiratory related cancers

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