The role of extracts from Eugenia uniflora L. against metal stress in eukaryotic and prokaryotic models

Souza, Celestina Elba Sobral de; Silva, A.R.P.; Leite, Nádghia Figueiredo; Rocha, Janaína Esmeraldo; Costa, José G. M.; Menezes, Irwin Rose Alencar de; Cunha, Francisco Assis Bezerra da; Rolim, Larissa Araújo; Sousa, Amanda Karine de; Coutinho, Henrique Douglas Melo

doi:10.1016/j.sajb.2020.03.012

Cited by 8 publications

(8 citation statements)

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“…In SEEU, flavonoids constitute the most representative class among the compounds identified, which is similar to the findings of Sobral-Souza et al [28]. In this study, the authors point out that the extract of E. uniflora is a promising source of flavonoids, which have a cytoprotective effect due to their antioxidative capacity.…”

Section: Characterization Of Seeu and Setmsupporting

confidence: 89%

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

et al. 2023

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Natural products can be used as complements or as alternatives to synthetic drugs. Eugenia uniflora and Tropaeolum majus are natives of Brazil and have antimicrobial, anti-inflammatory, and antioxidant activities. This study aimed to develop a film-forming system (FFS) loaded with plant extracts with the potential for treating microbial infections. E. uniflora and T. majus leaf extracts were prepared and characterized, and the individual and combined antioxidant and antimicrobial activities were evaluated. The FFS was developed with different concentrations of polyvinylpyrrolidone (PVP) and polyvinyl alcohol (PVA) and analyzed for physicochemical characteristics. The combination of extracts showed a superior antioxidant effect compared to the individual extracts, justifying the use of the blend. FFS prepared with 4.5% PVA, 4.5% PVP, 7.81% E. uniflora extract, and 3.90% T. majus extract was adhesive, lacked scale formation, presented good malleability, and had a suitable pH for topical application. In addition, the viscosity at rest was satisfactory for maintaining stability; water solubility was adequate; skin permeation was low; and the antimicrobial effect was superior to that of the individual extracts. Therefore, the developed FFS is promising for the differentiated treatment of skin lesions through topical application.

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Section: Characterization Of Seeu and Setmsupporting

confidence: 89%

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

et al. 2023

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“…Siebert et al (2019) studied the inhibitory activity of cherry juice on target enzymes in Alzheimer's and diabetes mellitus treatment and they discovered that, at least in part, the enzyme activity values (52.67% and 69.47%, respectively) are related to the presence of flavonoids. Sobral-Souza et al (2020) concluded that natural compounds from Eugenia uniflora are promising sources of natural products with antioxidant and chelating activity. Rodrigues et al (2020) found that the combination of furanone with pitanga extract could inhibit the growth of S. liquefaciens, a degrading microorganism of relevance in the dairy industry.…”

Section: Resultsmentioning

confidence: 99%

“…Some of the medicinal properties attributed to Eugenics fruits are biological actions that promote beneficial health effects. These are related to antioxidants that come from vitamins, carotenoids, and phenolic compounds such as flavonoids (Helt et al, 2018;Mendonça and Vieites, 2019;Castelucci et al, 2020;Ramos et al, 2020;Sobral -Souza et al, 2020;Rosa, 2021;Silva M. et al, 2021). The term flavonoid was derived from the Latin "flavus," which means yellow, and they are essential in the color of flowers.…”

Section: Introductionmentioning

confidence: 99%

The Presence of Flavonoids in Some Products and Fruits of the Genus Eugenia: An Integrative Review

Nogueira

Figueiredo

Ramos

et al. 2022

Front. Food. Sci. Technol.

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The Myrtaceae family, one of the most prominent botanical families, is represented in Brazil with different fruit species, rich in bioactive compounds and gastronomically appreciated. This study aimed to carry out an integrative review on the genus Eugenia, highlighting the pitangueira (E. uniflora L.), cagaiteira (E. dysenterica), grumixameira (E. brasiliensis), pereira (E. klotzschiana O. Berg), and uvaieira (E. pyriformis Cambess) and which flavonoids are present in these fruits. Articles published between 2016 and 2021 were selected from the following databases: Google Scholar, Periódicos CAPES, Scielo, and Science Direct. According to each database, the descriptors used as a search strategy addressed the popular and scientific names of the five selected species, associated or not with the term “flavonoid,” according to each database. The results showed that quercetin was the main flavonoid identified in the fruits, and the principal extraction method used was HPLC. Other interesting compounds, such as catechin, epicatechin, rutin, myricetin, and kaempferol, were also found. However, the amount and type of flavonoids detected varied according to the applied methodology. Hence, these studies highlight the importance of species of the genus Eugenia, which promotes beneficial health effects and possible applicability to the food and pharmaceutical industry.

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“…E. uniflora has a long history of traditional use in the treatment of various ailments, including rheumatism, hypertension, inflammation, disorders of the gastrointestinal tract, fever, and bronchitis (Bezerra et al, 2018; Sobeh et al, 2019). Numerous in vitro and in vivo studies have been conducted on the species, providing evidence for its pharmacological potential based on ethnopharmacological data (Candeia et al, 2022; Dos Santos et al, 2018; Ferreira et al, 2013; Sobeh et al, 2019; Sobral‐Souza et al, 2020). Among its most important activities are the antioxidant and antifungal properties (da Cunha et al, 2016; Falcão et al, 2018; Silva‐Rocha et al, 2015; Souza et al, 2018), which are closed linked to the phytochemical profile of the species.…”

Section: Introductionmentioning

confidence: 99%

“…pharmacological potential based on ethnopharmacological data (Candeia et al, 2022;Dos Santos et al, 2018;Ferreira et al, 2013;Sobeh et al, 2019;Sobral-Souza et al, 2020). Among its most important activities are the antioxidant and antifungal properties (da Cunha et al, 2016;Falcão et al, 2018;Silva-Rocha et al, 2015;Souza et al, 2018), which are closed linked to the phytochemical profile of the species.…”

mentioning

confidence: 99%

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

Santos

Lima

Machado

et al. 2023

Biomedical Chromatography

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The aim of this study is to demonstrate the stability‐indicating capacity of an analytical method for Eugenia uniflora, enhance understanding of the stability of myricitrin, and assess the effect of degradation of spray‐dried extract (SDE) on antioxidant and antifungal activities. Validation of the stability‐indicating method was carried out through a forced degradation study of SDE and standard myricitrin. The antioxidant and antifungal activities of SDE were evaluated both before and after degradation. The quantification method described was found to be both accurate and precise in measuring myricitrin levels in SDE from E. uniflora, with excellent selectivity that confirmed its stability‐indicating capability. The forced degradation study revealed that the marker myricitrin is sensitive to hydrolysis, but generally stable under other stress conditions. By contrast, the standard myricitrin displayed greater susceptibility to degradation under forced degradation conditions. Analysis of the antioxidant activity of SDE before and after degradation showed a negative impact in this activity due to degradation, while no significant effect was observed on antifungal activity. The method described can be a valuable tool in the quality control of E. uniflora, and the findings can assist in determining the optimal conditions and storage of products derived from this species.

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The role of extracts from Eugenia uniflora L. against metal stress in eukaryotic and prokaryotic models

Cited by 8 publications

References 50 publications

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

Bioprospecting a Film-Forming System Loaded with Eugenia uniflora L. and Tropaeolum majus L. Leaf Extracts for Topical Application in Treating Skin Lesions

The Presence of Flavonoids in Some Products and Fruits of the Genus Eugenia: An Integrative Review

Validation of stability‐indicating LC method, degradation study, and impact on antioxidant and antifungal activities of Eugenia uniflora leaves extract

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