2021
DOI: 10.1016/j.pneurobio.2021.102124
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The role of Extracellular Vesicles during CNS development

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Cited by 36 publications
(31 citation statements)
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“…Exosomes have been verified to promote neuronal repair and growth and modulate inflammation responses in many studies [ 29 ]. We have recently published the finding that SCDEs can promote the functional recovery after SCI by increasing autophagy and decreasing apoptosis, inducing axonal protection, decreasing the deposition of chondroitin sulfate proteoglycan (CSPG) and their detailed molecular mechanism.…”
Section: Discussionmentioning
confidence: 99%
“…Exosomes have been verified to promote neuronal repair and growth and modulate inflammation responses in many studies [ 29 ]. We have recently published the finding that SCDEs can promote the functional recovery after SCI by increasing autophagy and decreasing apoptosis, inducing axonal protection, decreasing the deposition of chondroitin sulfate proteoglycan (CSPG) and their detailed molecular mechanism.…”
Section: Discussionmentioning
confidence: 99%
“…They are able to cross the blood–brain barrier and therefore are a means of intercellular signalling to and from the central nervous system (CNS) [ 47 ]. EVs contribute to many physiological processes in the CNS, including: neural growth and development; CNS inflammation; the neuroprotective response to oxidative stress; and maintaining brain vascular integrity and post synaptic retrograde signalling [ 48 , 49 , 50 , 51 , 52 ]. EVs are also implicated in the pathological processes of neurodegeneration, and large numbers of studies have in recent years evaluated the role of EVs in neurodegenerative diseases, including ALS, Parkinson’s Disease (PD), Alzheimer’s Disease (AD), Huntington’s Disease and prion diseases [ 53 ].…”
Section: Evs In Alsmentioning
confidence: 99%
“…In CNS injuries and neurodegenerative diseases, NG2 glial cells rapidly proliferate and migrate to restore their population in focal cellular loss ( McTigue et al, 2001 ; Nishiyama et al, 2009 ; Kang et al, 2010 ; Hughes et al, 2013 ). NG2-glial cells-derived EVs are reported as the important intercellular transporter of retinoic acid and enable the cross talk between NG2 glial cells and neurons to mediate remyelination and axonal/neurite outgrowth ( Goncalves et al, 2019 ; Bahram Sangani et al, 2021 ). However, limited literature is available describing the role of EVs in neuron-NG2 glial cell communication.…”
Section: Various Kinds Of Extracellular Vesicles In Glia-neuron Intra...mentioning
confidence: 99%