The role of Extracellular Vesicles during CNS development

Sangani, Nasim Bahram; Gomes, Ana Rita; Curfs, Leopold; Reutelingsperger, Chris

doi:10.1016/j.pneurobio.2021.102124

Cited by 36 publications

(31 citation statements)

References 198 publications

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“…Exosomes have been verified to promote neuronal repair and growth and modulate inflammation responses in many studies [ 29 ]. We have recently published the finding that SCDEs can promote the functional recovery after SCI by increasing autophagy and decreasing apoptosis, inducing axonal protection, decreasing the deposition of chondroitin sulfate proteoglycan (CSPG) and their detailed molecular mechanism.…”

Section: Discussionmentioning

confidence: 99%

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Ren

Zhu

et al. 2023

Cell Death Dis

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Macrophage/microglia polarization acts as an important part in regulating inflammatory responses in spinal cord injury (SCI). However, the regulation of inflammation of Schwann cell-derived exosomes (SCDEs) for SCI repair is still unclear. Therefore, we intend to find out the effect of SCDEs on regulating the inflammation related to macrophage polarization during the recovery of SCI. Firstly, the thesis demonstrated that SCDEs could attenuate the LPS- inflammation in BMDMs by suppressing M1 polarization and stimulating M2 polarization. Similarly, SCDEs improved functional recovery of female Wistar rats of the SCI contusion model according to BBB (Basso, Beattie, and Bresnahan) score, electrophysiological assay, and the gait analysis system of CatWalk XT. Moreover, MFG-E8 was verified as the main component of SCDEs to improve the inflammatory response by proteomic sequencing and lentiviral transfection. Improvement of the inflammatory microenvironment also inhibited neuronal apoptosis. The knockout of MFG-E8 in SCs can reverse the anti-inflammatory effects of SCDEs treatment. The SOCS3/STAT3 signaling pathway was identified to participate in upregulating M2 polarization induced by MFG-E8. In conclusion, our findings will enrich the mechanism of SCDEs in repairing SCI and provide potential applications and new insights for the clinical translation of SCDEs treatment for SCI.

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Section: Discussionmentioning

confidence: 99%

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Ren

Zhu

et al. 2023

Cell Death Dis

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“…They are able to cross the blood–brain barrier and therefore are a means of intercellular signalling to and from the central nervous system (CNS) [ 47 ]. EVs contribute to many physiological processes in the CNS, including: neural growth and development; CNS inflammation; the neuroprotective response to oxidative stress; and maintaining brain vascular integrity and post synaptic retrograde signalling [ 48 , 49 , 50 , 51 , 52 ]. EVs are also implicated in the pathological processes of neurodegeneration, and large numbers of studies have in recent years evaluated the role of EVs in neurodegenerative diseases, including ALS, Parkinson’s Disease (PD), Alzheimer’s Disease (AD), Huntington’s Disease and prion diseases [ 53 ].…”

Section: Evs In Alsmentioning

confidence: 99%

Extracellular Vesicles in Amyotrophic Lateral Sclerosis

McCluskey

Morrison

Donaghy

et al. 2022

Life

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Amyotrophic Lateral Sclerosis is a progressive neurodegenerative disease and is the most common adult motor neuron disease. The disease pathogenesis is complex with the perturbation of multiple pathways proposed, including mitochondrial dysfunction, RNA processing, glutamate excitotoxicity, endoplasmic reticulum stress, protein homeostasis and endosomal transport/extracellular vesicle (EV) secretion. EVs are nanoscopic membrane-bound particles that are released from cells, involved in the intercellular communication of proteins, lipids and genetic material, and there is increasing evidence of their role in ALS. After discussing the biogenesis of EVs, we review their roles in the propagation of pathological proteins in ALS, such as TDP-43, SOD1 and FUS, and their contribution to disease pathology. We also discuss the ALS related genes which are involved in EV formation and vesicular trafficking, before considering the EV protein and RNA dysregulation found in ALS and how these have been investigated as potential biomarkers. Finally, we highlight the potential use of EVs as therapeutic agents in ALS, in particular EVs derived from mesenchymal stem cells and EVs as drug delivery vectors for potential treatment strategies.

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“…In CNS injuries and neurodegenerative diseases, NG2 glial cells rapidly proliferate and migrate to restore their population in focal cellular loss ( McTigue et al, 2001 ; Nishiyama et al, 2009 ; Kang et al, 2010 ; Hughes et al, 2013 ). NG2-glial cells-derived EVs are reported as the important intercellular transporter of retinoic acid and enable the cross talk between NG2 glial cells and neurons to mediate remyelination and axonal/neurite outgrowth ( Goncalves et al, 2019 ; Bahram Sangani et al, 2021 ). However, limited literature is available describing the role of EVs in neuron-NG2 glial cell communication.…”

Section: Various Kinds Of Extracellular Vesicles In Glia-neuron Intra...mentioning

confidence: 99%

Role of Extracellular Vesicles in Glia-Neuron Intercellular Communication

Ahmad

Srivastava

Singh

et al. 2022

Front. Mol. Neurosci.

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Cross talk between glia and neurons is crucial for a variety of biological functions, ranging from nervous system development, axonal conduction, synaptic transmission, neural circuit maturation, to homeostasis maintenance. Extracellular vesicles (EVs), which were initially described as cellular debris and were devoid of biological function, are now recognized as key components in cell-cell communication and play a critical role in glia-neuron communication. EVs transport the proteins, lipids, and nucleic acid cargo in intercellular communication, which alters target cells structurally and functionally. A better understanding of the roles of EVs in glia-neuron communication, both in physiological and pathological conditions, can aid in the discovery of novel therapeutic targets and the development of new biomarkers. This review aims to demonstrate that different types of glia and neuronal cells secrete various types of EVs, resulting in specific functions in intercellular communications.

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The role of Extracellular Vesicles during CNS development

Cited by 36 publications

References 198 publications

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Schwann cell-derived exosomes containing MFG-E8 modify macrophage/microglial polarization for attenuating inflammation via the SOCS3/STAT3 pathway after spinal cord injury

Extracellular Vesicles in Amyotrophic Lateral Sclerosis

Role of Extracellular Vesicles in Glia-Neuron Intercellular Communication

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