The Role of Extracellular Matrix in Skin Wound Healing

Abstract

Impaired wound healing is one of the unsolved problems of modern medicine, affecting patients’ quality of life and causing serious economic losses. Impaired wound healing can manifest itself in the form of chronic skin wounds or hypertrophic scars. Research on the biology and physiology of skin wound healing disorders is actively continuing, but, unfortunately, a single understanding has not been developed. The attention of clinicians to the biological and physiological aspects of wound healing in the skin is necessary for the search for new and effective methods of prevention and treatment of its consequences. In addition, it is important to update knowledge about genetic and non-genetic factors predisposing to impaired wound healing in order to identify risk levels and develop personalized strategies for managing such patients. Wound healing is a very complex process involving several overlapping stages and involving many factors. This thematic review focuses on the extracellular matrix of the skin, in particular its role in wound healing. The authors analyzed the results of fundamental research in recent years, finding promising potential for their transition into real clinical practice.

β‐Elemene induces apoptosis by activating the P53 pathway in human hypertrophic scar fibroblasts

“…While in HS, the ratio of collagen I/III is increased. 5 In the case of excessive inflammation, fibroblasts proliferation is excessive but apoptosis is inhibited, collagen fibers are excessively secreted, and ECM mainly composed of collagen is induced to be synthesized and excessively deposited, which, in turn, promotes the formation of HS. 2 Therefore, the key to the treatment of HS is how to inhibit the proliferation of fibroblasts, reduce the production of collagen, and thereby reduce the deposition of collagen.…”

“…The two types of collagen I and collagen III secreted by fibroblasts are the most effective collagens during wound repair. While in HS, the ratio of collagen I/III is increased 5 . In the case of excessive inflammation, fibroblasts proliferation is excessive but apoptosis is inhibited, collagen fibers are excessively secreted, and ECM mainly composed of collagen is induced to be synthesized and excessively deposited, which, in turn, promotes the formation of HS 2 .…”

Synergistic effect of microneedle-delivered extracellular matrix compound and radiofrequency on rejuvenation of periorbital wrinkles

“…Extracellular matrix (ECM), including collagen, elastin, hyaluronic acid, laminin, fibrin, and integrins, helps skin tissue to maintain homeostasis and youthful appearance (8). Nowadays, many cosmetic products are focusing on the ECM components to achieve facial rejuvenation effect.…”

A Polysaccharide Isolated from the Herb Bletilla striata Combined with Methylcellulose to Form a Hydrogel via Self-Assembly as a Wound Dressing

“…Wound healing is a complicated physiological process including three overlapping phases: inflammation, cell migration, and remodeling [ 1 , 2 ]. The inflammatory phase of the wound-healing process is regarded as critical because it serves as a precursor to tissue formation and remodeling.…”