The Role of Extracellular Matrix in Tissue Regeneration

Kusindarta, Dwi Liliek; Wihadmadyatami, Hevi

doi:10.5772/intechopen.75728

Cited by 67 publications

(65 citation statements)

References 15 publications

(14 reference statements)

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“…Both the plasma and cellular forms usually consist of two almost the same subunits, which are composed of three distinct types of repeating modules (Types I-III). The main role of this glycoprotein is to enhance cell migration, adhesion, spreading, and proliferation, but it is also necessary for the development of many tissues and organs during embryogenesis [37,38,75]. It also plays important roles in cellular morphology and wound healing.…”

Section: Fibronectinmentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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Polymer scaffolds constitute a very interesting strategy for tissue engineering. Even though they are generally non-toxic, in some cases, they may not provide suitable support for cell adhesion, proliferation, and differentiation, which decelerates tissue regeneration. To improve biological properties, scaffolds are frequently enriched with bioactive molecules, inter alia extracellular matrix proteins, adhesive peptides, growth factors, hormones, and cytokines. Although there are many papers describing synthesis and properties of polymer scaffolds enriched with proteins or peptides, few reviews comprehensively summarize these bioactive molecules. Thus, this review presents the current knowledge about the most important proteins and peptides used for modification of polymer scaffolds for tissue engineering. This paper also describes the influence of addition of proteins and peptides on physicochemical, mechanical, and biological properties of polymer scaffolds. Moreover, this article sums up the major applications of some biodegradable natural and synthetic polymer scaffolds modified with proteins and peptides, which have been developed within the past five years.

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Section: Fibronectinmentioning

confidence: 99%

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

2020

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“…Proteins, proteoglycans, glycoproteins, and polysaccharides are the main components of the ECM. The interactions between the ECM components and cell receptors allow the creation of a complex network [ 6 , 7 ].…”

Section: Extracellular Matrixmentioning

confidence: 99%

“…Another important change concerns the production by the endothelial cells of neo-synthetized ECM molecules such as collagen, fibronectin, and glycosaminoglycans (GAGs) with the function to modulate the adhesion of the cells through integrins [ 7 , 9 ]. The integrin receptors are the main regulators in the early part of angiogenesis because they potentiate the signaling events.…”

Section: Extracellular Matrixmentioning

confidence: 99%

Angiogenic Potential in Biological Hydrogels

Giraudo

Francesco

Catoira³

et al. 2020

Biomedicines

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Hydrogels are three-dimensional (3D) materials able to absorb and retain water in large amounts while maintaining their structural stability. Due to their considerable biocompatibility and similarity with the body’s tissues, hydrogels are one of the most promising groups of biomaterials. The main application of these hydrogels is in regenerative medicine, in which they allow the formation of an environment suitable for cell differentiation and growth. Deriving from these hydrogels, it is, therefore, possible to obtain bioactive materials that can regenerate tissues. Because vessels guarantee the right amount of oxygen and nutrients but also assure the elimination of waste products, angiogenesis is one of the processes at the base of the regeneration of a tissue. On the other hand, it is a very complex mechanism and the parameters to consider are several. Indeed, the factors and the cells involved in this process are numerous and, for this reason, it has been a challenge to recreate a biomaterial able to adequately sustain the angiogenic process. However, in this review the focal point is the application of natural hydrogels in angiogenesis enhancing and their potential to guide this process.

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“…It is also named as cell support device. It acts as ECM(Extracellular matrix) for cell growth and regeneration [2].The structure of scaffold is highly porous. Scaffold is formed by using various biomaterials, ceramics, synthetic and natural polymers and even textiles are also used because of their structure [3].…”

Section: Scaffoldmentioning

confidence: 99%

Tissue Engineering – The Current Scenario & Innovations

Dhir¹

2020

IJMTST

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Tissue engineering is an emerging field in medical arena which combines the knowledge of science and engineering to accomplish the increasing demands to aid the damaged tissues or even a whole organ. With time various methods of tissue engineering such as traditional scaffold method ,advanced 3D bioprinting technology and the use of bio ink (the extracellular matrix materials) have become popular at various medical levels. Scaffold is a 3D structure which results in tissue formation by providing space for cells to attach, to proliferate in various directions & by secreting extracellular matrix. Also, the recent development is the use of decellularised extracellular material i.e. dECM as bio-ink to generate vascular organs like Kidney & Heart. Textiles have been playing an indispensable role in tissue engineering as it provide superior methods over other ways to fabricate scaffold. The use of smart biomaterial based scaffolds costs less and is more effective which gives advantage to tailor the tissues according to individual's tissue structure . This paper reviews the application of textiles technology in tissue engineering, various approaches of tissue engineering from traditional to the currently used approach , recent advances and its indications.

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The Role of Extracellular Matrix in Tissue Regeneration

Cited by 67 publications

References 15 publications

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Proteins and Peptides as Important Modifiers of the Polymer Scaffolds for Tissue Engineering Applications—A Review

Angiogenic Potential in Biological Hydrogels

Tissue Engineering – The Current Scenario & Innovations

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