The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

Aili, Yirizhati; Maimaitiming, Nuersimanguli; Mahemuti, Yusufu; Hu, Qin; Wang, Yongxin; Wang, Zengliang

doi:10.3389/fonc.2021.686369

Cited by 20 publications

(18 citation statements)

References 111 publications

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“…In addition, it was found that B- and T-lymphocyte attenuator (BTLA) was positively correlated with the expression of macrophages. Blocking BTLA can significantly block the inhibition of T cell proliferation by macrophages [ 48 ]. In addition, blocking PD-L1 can significantly block the inhibition of T cell proliferation by mononuclear phagocytes.…”

Section: Tams and Tumor Microenvironmentmentioning

confidence: 99%

The Role of TAMs in Tumor Microenvironment and New Research Progress

Feng

Song

et al. 2022

Stem Cells International

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Tumor-associated macrophages (TAMs) are an important part of tumor microenvironment (TME) and play a key role in TME, participating in the process of tumor occurrence, growth, invasion, and metastasis. Among them, metastasis to tumor tissue is the key step of malignant development of tumor. In this paper, the latest progress in the role of TAMs in the formation of tumor microenvironment is summarized. It is particularly noteworthy that cell and animal experiments show that TAMs can provide a favorable microenvironment for the occurrence and development of tumors. At the same time, clinical pathological experiments show that the accumulation of TAMs in tumor is related to poor clinical efficacy. Finally, this paper discusses the feasibility of TAMs-targeted therapy as a new indirect cancer therapy. This paper provides a theoretical basis for finding a potentially effective macrophage-targeted tumor therapy.

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Section: Tams and Tumor Microenvironmentmentioning

confidence: 99%

The Role of TAMs in Tumor Microenvironment and New Research Progress

Feng

Song

et al. 2022

Stem Cells International

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“…Studies have demonstrated that exosomes have the ability to regulate a variety of complex signaling pathways by mediating small molecules such as miRNAs, which provides a powerful tool for GBM [ 112 , 113 ]. The biological functions of exosomal microRNAs -gene regulatory factors -are different in glioma.…”

Section: Role Of Exosome In Delivery Of Effective Therapeutics For Gb...mentioning

confidence: 99%

“…Exosomal microRNAs have been used successfully as biomarkers and therapeutic targets in other diseases. In recent studies, exosomal miRNA plays an important role in glioma occurrence, invasion, development, metastasis, and treatment resistance [ 112 ]. For precise glioma treatment, the use of exosomal miRNAs in combination with exosomes and transcriptomics is expected to be a new approach [ 112 , 115 ].…”

Section: Role Of Exosome In Delivery Of Effective Therapeutics For Gb...mentioning

confidence: 99%

“…In recent studies, exosomal miRNA plays an important role in glioma occurrence, invasion, development, metastasis, and treatment resistance [ 112 ]. For precise glioma treatment, the use of exosomal miRNAs in combination with exosomes and transcriptomics is expected to be a new approach [ 112 , 115 ]. Sakr et al [ 116 ] have shown the transfection of miR-150-5p or miR-133a mimics into the exosomes generated from glioma cells and co-cultured these exosomes with glioma cells.…”

Section: Role Of Exosome In Delivery Of Effective Therapeutics For Gb...mentioning

confidence: 99%

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Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy

et al. 2023

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Gliomas make up virtually 80% of all lethal primary brain tumors and are categorized based on their cell of origin. Glioblastoma is an astrocytic tumor that has an inferior prognosis despite the ongoing advances in treatment modalities. One of the main reasons for this shortcoming is the presence of the blood-brain barrier and blood-brain tumor barrier. Novel invasive and non-invasive drug delivery strategies for glioblastoma have been developed to overcome both the intact blood-brain barrier and leverage the disrupted nature of the blood-brain tumor barrier to target cancer cells after resection—the first treatment stage of glioblastoma. Exosomes are among non-invasive drug delivery methods and have emerged as a natural drug delivery vehicle with high biological barrier penetrability. There are various exosome isolation methods from different origins, and the intended use of the exosomes and starting materials defines the choice of isolation technique. In the present review, we have given an overview of the structure of the blood-brain barrier and its disruption in glioblastoma. This review provided a comprehensive insight into novel passive and active drug delivery techniques to overcome the blood-brain barrier, emphasizing exosomes as an excellent emerging drug, gene, and effective molecule delivery vehicle used in glioblastoma therapy. Supplementary Information The online version contains supplementary material available at 10.1007/s12035-023-03365-0.

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“…Studies have also shown that plasmin found in the CNS can induce apoptosis of tumor cells; however, breast and lung cancer cell lines highly express neuroserpin, a neuronal inhibitor of plasminogen activator, thereby evading the pro-apoptotic effect of plasmin ( 127 ). This finding may be based on the fact that high levels of chloride in the interstitial fluid have a damaging effect on non-neuronal cells; coupled with the abundant neurotrophic factors, glutamate, and other substances in the CNS, this may induce certain neuronal properties in tumor cells to make them more suitable for survival in the CNS microenvironment ( 128 ).…”

Section: Biological Characteristics Of Tumor Cells In the Brain Metas...mentioning

confidence: 99%

Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application

Aili

Maimaitiming²,

Hu³

et al. 2022

Front. Oncol.

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Metastasis is one of the important biological features of malignant tumors and one of the main factors responsible for poor prognosis. Although the widespread application of newer clinical technologies and their continuous development have significantly improved survival in patients with brain metastases, there is no uniform standard of care. More effective therapeutic measures are therefore needed to improve prognosis. Understanding the mechanisms of tumor cell colonization, growth, and invasion in the central nervous system is of particular importance for the prevention and treatment of brain metastases. This process can be plausibly explained by the “seed and soil” hypothesis, which essentially states that tumor cells can interact with various components of the central nervous system microenvironment to produce adaptive changes; it is this interaction that determines the development of brain metastases. As a novel form of intercellular communication, exosomes play a key role in the brain metastasis microenvironment and carry various bioactive molecules that regulate receptor cell activity. In this paper, we review the roles and prospects of brain metastatic tumor cells, the brain metastatic tumor microenvironment, and exosomes in the development and clinical management of brain metastases.

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The Role of Exosomal miRNAs in Glioma: Biological Function and Clinical Application

Cited by 20 publications

References 111 publications

The Role of TAMs in Tumor Microenvironment and New Research Progress

The Role of TAMs in Tumor Microenvironment and New Research Progress

Exosomes: Promising Delivery Tools for Overcoming Blood-Brain Barrier and Glioblastoma Therapy

Tumor microenvironment and exosomes in brain metastasis: Molecular mechanisms and clinical application

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