The Role of Exogenous Oxytocin in Lactating Ewe

Martinet, J.; Morag, M.; Denamur, R

doi:10.1051/rnd:19760607

Cited by 4 publications

(1 citation statement)

References 21 publications

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“…20 Oxytocin injections were used in experiment 2 to increase milk letdown and appeared effective, together with machine milking (which is more physiologic than hand milking), in increasing milk production. [21][22][23] At the end of experiment 2, however, mares had become resentful of the injections.…”

Section: Discussionmentioning

confidence: 99%

Quantitative and Qualitative Assessment of Milk Production after Pharmaceutical Induction of Lactation in the Mare

Chavatte-Palmer

Arnaud²,

Duvaux-Ponter

et al. 2002

Veterinary Internal Medicne

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The induction of lactation is performed in ruminants by steroidogenic impregnation, followed by drugs intended to increase prolactin secretion. The aim of this study was to induce lactation in barren mares and to evaluate milk production. Five treated and 5 control mares were used in June and September in year 1, and 12 mares were used in year 2. Mares were administered a vaginal pessary (500 mg altrenogest and 50 mg estradiol benzoate) for 1 week. The 2nd week, another sponge with 100 mg estradiol benzoate was administered, together with 50 mg/100 kg body weight (BW) sulpiride in oil (IM q12h). All mares were milked by hand. Drug treatment was stopped after I L was obtained. Milk production and composition and plasma prolactin concentration were measured. In year 2, the same steroid treatment was applied, but mares received sulpiride (n = 6) or domperidone (1.1 mg/kg PO q12h) (n = 6). A milking machine and oxytocin injections 1 minute before the start of milking were used. In year 1, all treated mares started milking within 1-5 days after sulpiride treatment. Mean daily milk production was 0.88 +/- 0.52 L/500 kg BW. Milk immunoglobulin G (IgG) contents increased in all mares (IgG concentration range, 14-92 g/L). Plasma prolactin increased during sulpiride treatment (range. 27.7 +/- 2.9 to 43.7 +/- 6.7 ng/mL [before] to 289.0 +/- 7.8 ng/mL during treatment, P < .001). In year 2, results were similar to those in year 1, with peak IgG concentrations ranging from 4.2 to 106.7 g/L and a larger daily milk production (3.13 +/- 0.75 with sulpiride and 3.45 +/- 0.51 L/500 kg BW with domperidone). In conclusion, lactation can be induced in mares within 2 weeks, and some mares produce good-quality colostrum.

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Section: Discussionmentioning

confidence: 99%