The role of exercise on peripheral nerve regeneration: from animal model to clinical application

Maugeri, Grazia; D’Agata, Velia; Trovato, Bruno; Roggio, Federico; Castorina, Alessandro; Vecchio, Michele; Rosa, Michelino Di; Musumeci, Giuseppe

doi:10.1016/j.heliyon.2021.e08281

Cited by 47 publications

(50 citation statements)

References 81 publications

(93 reference statements)

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“…Peripheral nerve injuries represent a substantial clinical problem ( Faroni et al, 2015 ; Lopes et al, 2022 ; Maugeri et al, 2021 ), the physical activity increase neuroprotection and improve functional recovery by acting on neurotrophic factors which makes an effective treatment, furthermore it is accessible for everyone ( Cobianchi et al, 2017 ). On the current protocol the association of time (1 hr/day) and overload was not favorable to the nerve regeneration and muscular integrity interfering on the functional recovery.…”

Section: Discussionmentioning

confidence: 99%

“…The peripheral nerve injury promotes motor, autonomic, and sensory alterations in the denervated territory. The peripheral nerve injuries are cause of physical disability, debilitating neuropathic pain, personal and social cost, affecting directly the life quality ( Lopes et al, 2022 ; Maugeri et al, 2021 ; Panagopoulos et al, 2017 ; Udina et al, 2011a ).…”

Section: Introductionmentioning

confidence: 99%

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Negative neuromuscular and functional repercussion of forced swimming after axonotmesis

Moura¹,

Morais²,

Barbosa³

et al. 2022

J Exerc Rehabil

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Peripheral nerve injuries are cause of sensory disturbances and in functional abilities, and are associated personal and social costs. Strat-egies that maximize nerve regeneration and functional recovery are necessary, the exercise is an option. This study evaluated the effects of forced swimming exercise on neuromuscular histomorphometry and on functional recovery in a median nerve crush model. Sixteen Wistar rats underwent median nerve crush and were divided into control group (CG) and swimming group (SG). The forced swimming protocol started one week after the injury and was performed for 1 hr a day, 5 days per week, for 2 weeks. The rats swam with an overload of 5% and 10% of body weight in the first and second week, respectively. The functional recovery was assessed in three moments using the grasping test. On day 21, fragments of the median nerve and of the forearm flexors mus-cles were removed for histomorphometric analysis. The SG had func-tional recovery impaired (p<0.001) and presented lower myelinated fi-bers number, fiber and axon minimal diameter, myelin thickness and g-ratio in the proximal e distal segments of the median nerve (p<0.005) and area muscle fiber (p<0.005) than CG. Also, the SG presented a number of capillaries in the proximal segments of the median nerve greater than CG (p<0.005). The exercise protocol used in this study im-paired the regeneration of the median nerve and negatively influenced the functional recovery.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Negative neuromuscular and functional repercussion of forced swimming after axonotmesis

Moura¹,

Morais²,

Barbosa³

et al. 2022

J Exerc Rehabil

View full text Add to dashboard Cite

show abstract

“…Among non-surgical therapies for traumatic peripheral nerve injuries, compelling evidence has highlighted the effectiveness of the “activity-related therapies,” such as electrical stimulation and exercise, in boosting axonal regeneration and reinnervation of the target muscle ( Geremia et al, 2007 ; Sabatier et al, 2008 ; Asensio-Pinilla et al, 2009 ; Sartini et al, 2013 ). Notably, among the activity-related therapies, there has been a growing interest in evaluating the effects of exercise on peripheral nerve injuries in light that it is relatively riskless and provides pleiotropic effect in promoting metabolic and psychological well-being by ameliorating general health besides boosting the functional recovery upon traumatic injuries ( Maugeri et al, 2021 ). However, exercise is not a panacea per se.…”

Section: Discussionmentioning

confidence: 99%

The impact of different exercise protocols on rat soleus muscle reinnervation and recovery following peripheral nerve lesion and regeneration

Palma

Ambrogini²,

Lattanzi³

et al. 2022

Front. Physiol.

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Background: Incomplete functional recovery following traumatic peripheral nerve injury is common, mainly because not all axons successfully regenerate and reinnervate target muscles. Exercise can improve functional outcomes increasing the terminal sprouting during the muscle reinnervation. However, exercise is not a panacea per se. Indeed, the type of exercise adopted dramatically impacts the outcomes of rehabilitation therapy. To gain insight into the therapeutic effects of different exercise regimens on reinnervation following traumatic nerve lesion, we evaluated the impact of different clinically transferable exercise protocols (EPs) on metabolic and functional muscle recovery following nerve crush.Methods: The reinnervation of soleus muscle in adult nerve-crushed rats was studied following 6 days of different patterns (continuous or intermittent) and intensities (slow, mid, and fast) of treadmill running EPs. The effects of EPs on muscle fiber multiple innervation, contractile properties, metabolic adaptations, atrophy, and autophagy were assessed using functional and biochemical approaches.Results: Results showed that an intermittent mid-intensity treadmill EP improves soleus muscle reinnervation, whereas a slow continuous running EP worsens the functional outcome. However, the mid-intensity intermittent EP neither enhanced the critical mediators of exercise-induced metabolic adaptations, namely, PGC-1α, nor improved muscle atrophy. Conversely, the autophagy-related marker LC3 increased exclusively in the mid-intensity intermittent EP group.Conclusion: Our results demonstrated that an EP characterized by a mid-intensity intermittent activity enhances the functional muscle recovery upon a nerve crush, thus representing a promising clinically transferable exercise paradigm to improve recovery in humans following peripheral nerve injuries.

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“…This Special Issue bridging the gap between science and practice in the promotion of exercise and health and in the scientific assessment, study, and understanding of sports performance, sports injury prevention and treatment, exercise for health as non-surgical and nonpharmacological treatments, rehabilitation techniques, adapted physical activity, drugs in sport, and recommendations for training and nutrition. This Special issue comprises 3 review articles and 16 original research publications from a number of Sports Medicine and Sciences researchers [6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24]. Taken together, these articles are…”

Section: J O U R N a L P R E -P R O O Fmentioning

confidence: 99%

Sports Medicine and Movement Sciences

Musumeci

2022

Heliyon

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The role of exercise on peripheral nerve regeneration: from animal model to clinical application

Cited by 47 publications

References 81 publications

Negative neuromuscular and functional repercussion of forced swimming after axonotmesis

Negative neuromuscular and functional repercussion of forced swimming after axonotmesis

The impact of different exercise protocols on rat soleus muscle reinnervation and recovery following peripheral nerve lesion and regeneration

Sports Medicine and Movement Sciences

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