The role of exercise-induced myokines in promoting angiogenesis

Qi, Chao; Song, Xianjing; Wang, He; Yan, Youyou; Liu, Bin

doi:10.3389/fphys.2022.981577

Cited by 18 publications

(8 citation statements)

References 94 publications

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“…Myokine responses are mostly studied as a post-exercise phenomenon, where IL-6 released from muscle during strenuous activity have received attention for its proposed benefits on metabolism and systemic inflammation. However, the endocrine muscle is an area of vivid research [53], exploring potential muscle-pancreatic beta cells [54], -cardiomyocytes [55], and -adipocyte [52,56] and -vascular bed [57] crosstalk, implicating diabetes, cardiovascular and metabolic health. Similarly, we cannot exclude the possibility that a muscle secretome includes factors that have direct beneficial effects on vascular endothelial and smooth muscle cells that assist in maintaining cavernous arteriolar function.…”

Section: Discussionmentioning

confidence: 99%

Muscle Strength and Male Sexual Function

Viken,

Siiak,

Schlünssen

et al. 2024

JCM

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Sexual dysfunction, in particular erectile dysfunction, is a common complaint among aging men. Obesity, diabetes, hypertension, and smoking are shown to be independent risk factors for erectile dysfunction, while cardiorespiratory fitness is shown to be protective. Less is known about the role of muscle strength in male sexual function. Our objective was to study the association between male sexual function and typical cardiovascular risk factors, together with exercise and muscle strength. We included data from the fourth wave of the RHINE study. Data on anthropometrics, exercise habits, diseases, muscle strength, and sexual function were collected using questionnaires, including the Aging Males’ Symptoms (AMS) scale. We used multivariable logistic regression analysis to measure the association between sexual function and body mass index (BMI), age, smoking, diabetes, hypertension, exercise and muscle strength status. We included 2116 men aged 48–75 from four Nordic-Baltic countries. BMI, age, smoking, diabetes, and hypertension were found to be associated with higher odds of reporting decreased sexual function, while reporting intact muscle strength was associated with lower odds. In a large Nordic-Baltic male study population, we show that known cardiovascular risk factors are associated with decreased sexual function, while reporting intact muscle strength is associated with lower odds of reporting decreased sexual function.

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Section: Discussionmentioning

confidence: 99%

Muscle Strength and Male Sexual Function

Viken,

Siiak,

Schlünssen

et al. 2024

JCM

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“…During acute exercise, serum inflammatory and anti-inflammatory biomarkers values change [ 33 ]. This is because muscles produce myokines that induce several physiological effects via paracrine or autocrine secretion during exercise [ 34 ]. When we performed the quantitative review analysis to understand the influence of arginine on inflammatory and anti-inflammatory markers following exercise, no significant influence of this intervention was reported.…”

Section: Discussionmentioning

confidence: 99%

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

et al. 2023

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Background: The repercussions on oxidative and inflammatory stress markers under the effects of arginine and citrulline in response to exercise are not fully reached. We completed a systematic review to investigate the effects of L-Citrulline or L-Arginine on oxidative stress and inflammatory biomarkers following exercise. EMBASE, MEDLINE (PubMed), Cochrane Library, CINAHL, LILACS, and Web of Science databases were used to record the trials. This study includes randomized controlled trials (RCTs) and non-RCTs with subjects over 18 years old. Those under the intervention protocol consumed L-Citrulline or L-Arginine, and the controls ingested placebo. We recognized 1080 studies, but only 7 were included (7 studies in meta-analysis). We observed no difference between pre- vs. post-exercise for oxidative stress (subtotal = −0.21 [CI: −0.56, 0.14], p = 0.24, and heterogeneity = 0%. In the sub-group “L-Arginine” we found a subtotal = −0.29 [−0.71, 0.12], p = 0.16, and heterogeneity = 0%. For the “L-Citrulline” subgroup we observed a subtotal = 0.00 [−0.67, 0.67], p = 1.00, and heterogeneity was not applicable. No differences were observed between groups (p = 0.47), and I² = 0%) or in antioxidant activity (subtotal = −0.28 [−1.65, 1.08], p = 0.68, and heterogeneity = 0%). In the “L-Arginine” sub-group, we found a subtotal = −3.90 [−14.18, 6.38], p = 0.46, and heterogeneity was not applicable. For the “L-Citrulline” subgroup, we reported a subtotal = −0.22 [−1.60, 1.16], p = 0.75, and heterogeneity was not applicable. No differences were observed between groups (p = 0.49), and I² = 0%), inflammatory markers (subtotal = 8.38 [−0.02, 16.78], p = 0.05, and heterogeneity = 93%. Tests for subgroup differences were not applicable, and anti-inflammatory markers (subtotal = −0.38 [−1.15, 0.39], p = 0.34 and heterogeneity = 15%; testing for subgroup differences was not applicable). In conclusion, our systematic review and meta-analysis found that L-Citrulline and L-Arginine did not influence inflammatory biomarkers and oxidative stress after exercise.

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“…Breast feeding and maternal aggression are behaviourally linked through hormones and neuropeptides and together appear to reduce anxiety and blood pressure [29,30]. Angiogenesis is a complex process affected by a diversity of hormones, growth factors, neuropeptides, and neuroamines that are behaviourally regulated [31][32][33][34][35][36][37][38][39].…”

Section: The Behaviour-physiology Interfacementioning

confidence: 99%

“Vitaction” deficiency: a possible root cause for multiple lifestyle disorders including Alzheimer’s disease

Watve,

Keskar Sardeshmukh

2024

Explor Neuroprot Ther

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Behavioural environment and behavioural responses of an individual are known to affect multiple aspects of physiology including neuroendocrine and growth factor signalling, angiogenesis, stem cell dynamics, tissue homeostasis, and maintenance. Despite substantial evidence, the role of behaviour-physiology interface in human health and disease remains underappreciated. The hypothesis proposed here suggests that deficiencies of certain behaviours that have evolved to become essential or “vitactions” can potentially trigger multiple health problems. Altered growth factor expression because of vitaction deficiencies affects angiogenesis and vascular function, neuronal maintenance, transport of glucose and other nutrients to the brain, mitochondrial function, oxidative stress, inflammation, and protein aggregation dynamics all implicated in Alzheimer’s disease (AD). Exercise is already known to be effective in prevention of AD. The hypothesis suggests that it is the behavioural component of exercise over mechanical activity and calorie burning that has crucial effects on brain health through multiple signalling pathways. Similar to vitamin deficiencies, where supplying the deficient vitamin is the only effective solution, for vitaction deficiencies supplying the deficient behavioural stimuli through behaviourally enriched exercise can be the most effective remedy.

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The role of exercise-induced myokines in promoting angiogenesis

Cited by 18 publications

References 94 publications

Muscle Strength and Male Sexual Function

Muscle Strength and Male Sexual Function

Absence of Effects of L-Arginine and L-Citrulline on Inflammatory Biomarkers and Oxidative Stress in Response to Physical Exercise: A Systematic Review with Meta-Analysis

“Vitaction” deficiency: a possible root cause for multiple lifestyle disorders including Alzheimer’s disease

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