The role of event-related potentials in cognitive decline in Alzheimer’s disease

Lai, Chiou-Lian; Lin, Ruey‐Tay; Liou, Li-Min; Liu, Ching-Kuan

doi:10.1016/j.clinph.2009.11.001

Cited by 129 publications

(109 citation statements)

References 40 publications

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“…For example, when it reflects certain mental activity, such as attention, memory, intelligence and so on. The P300 latency may be more sensitive than neuropsychological tests in the longitudinal follow-up of AD patients when it reflects cognitive decline [31]. The P300 amplitude and latency also distinguished the groups and showed a significant correlation with response speed [32].…”

Section: Discussionmentioning

confidence: 93%

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Zhu¹,

Chai²,

Gao³

et al. 2017

J Neurol Disord

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Section: Discussionmentioning

confidence: 93%

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Zhu¹,

Chai²,

Gao³

et al. 2017

J Neurol Disord

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“…However, cognitive evoked potentials have many advantages: a fine temporal resolution, the method allows differential assessments of the patient's responsiveness to a large array of stimulus conditions, the equipment is relatively inexpensive, sometimes the results are unequivocal or may reflect cognitive decline more sensitively than neuropsychological tests in the longitudinal follow-up of patients [33,34]. Table 3 Comparison between ERP parameters obtained from the two groups of subjects at ISI 2,400 ms…”

Section: Discussionmentioning

confidence: 99%

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

Raggi

Tasca

Rundo

et al. 2013

Behavioural Neurology

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Abstract. Complex higher-order cognitive functions and their possible changes with aging are mandatory objectives of cognitive neuroscience. Event-related potentials (ERPs) allow investigators to probe the earliest stages of information processing. N100, Mismatch negativity (MMN) and P3a are auditory ERP components that reflect automatic sensory discrimination. The aim of the present study was to determine if N100, MMN and P3a parameters are stable in healthy aged subjects, compared to those of normal young adults. Normal young adults and older participants were assessed using standardized cognitive functional instruments and their ERPs were obtained with an auditory stimulation at two different interstimulus intervals, during a passive paradigm. All individuals were within the normal range on cognitive tests. No significant differences were found for any ERP parameters obtained from the two age groups. This study shows that aging is characterized by a stability of the auditory discrimination and novelty processing. This is important for the arrangement of normative for the detection of subtle preclinical changes due to abnormal brain aging.

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“…Previous research reported that the P3 latency was stable and sensitive in cognitive evaluations of MCI patients and those with conversion from MCI to AD [23]. Indeed, a number of experimental studies also demonstrated prolonged P3 latency in the elderly with aMCI [21,72] and MCI [73][74][75] when performing the visual and auditory oddball tasks. Therefore, in support of these earlier findings, the prolonged P3 latency found in the current paper seems to be a neuropathological characteristic of MCI.…”

Section: Discussionmentioning

confidence: 97%

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

Tsai

Pai

Ukropec

et al. 2016

JAD

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Abstract. Although elderly people with amnestic mild cognitive impairment (aMCI) have been found to show impaired behavioral performance in task switching, no research has yet explored the electrophysiological mechanisms and the potential correlation between physical fitness and neurocognitive (i.e., behavioral and electrophysiological) performance in aMCI. The present study was thus aimed to examine whether there are differences in electrophysiological (i.e., event-related potential) performance between aMCI participants and controls when performing a task-switching paradigm, and to investigate the role of physical fitness in the relationship between neurocognitive performance and aMCI. Sixty participants were classified into aMCI (n = 30) and control (n = 30) groups, and performed a task-switching paradigm with concomitant electrophysiological recording, as well as underwent senior functional physical fitness tests. The aMCI group showed comparable scores on most parts of the physical fitness tests, but reduced lower body flexibility and VO 2max as compared to the control group. When performing the task-switching paradigm, the aMCI group showed slower reaction times in the heterogeneous condition and larger global switching costs, although no significant difference was observed in accuracy rates between the two groups. In addition, the aMCI group showed significantly prolonged P3 latencies in the homogeneous and heterogeneous conditions, and a smaller P3 amplitude only in the heterogeneous condition. The level of cardiorespiratory fitness was significantly correlated with P3 amplitude in the aMCI group, particularly in the heterogeneous condition of the task-switching paradigm. These results show that the aMCI group exhibited abnormalities in their neurocognitive performance when performing the task-switching paradigm and such a deficit was likely associated with reduced cardiorespiratory fitness, which was shown to be the important predictor of neurocognitive performance.

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The role of event-related potentials in cognitive decline in Alzheimer’s disease

Cited by 129 publications

References 40 publications

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Analysis of EEG Complexity in Patients with Mild Cognitive Impairment

Stability of Auditory Discrimination and Novelty Processing in Physiological Aging

The Role of Physical Fitness in the Neurocognitive Performance of Task Switching in Older Persons with Mild Cognitive Impairment

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