The Role of Epistasis in the Etiology of Polycystic Ovary Syndrome among Indian Women: SNP‐SNP and SNP‐Environment Interactions

Dasgupta, Shilpi; Reddy, B. Mohan

doi:10.1111/ahg.12020

Cited by 26 publications

(17 citation statements)

References 20 publications

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“…In this study, majority of the infertile PCOS women were from a middle socioeconomic class (44%). This study result is higher as compared to that reported by Dasgupta and Reddy, in Hyderabad, India [11], wherein most of the PCOS women were from low-middle socioeconomic class (38.4%). In this study, the prevalence PCOS women (65.71%) in urban areas were found to be higher than their rural counterparts.…”

Section: Discussioncontrasting

confidence: 75%

Prescription Pattern in Obese and Non-Obese Infertile Women With Polycystic Ovary Syndrome in a Tertiary Care Hospital

Avirah

Alias

Sajith

et al. 2018

Asian J Pharm Clin Res

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Objective: The objective of this study is to evaluate the treatment options for the management of obese and non-obese infertile women with polycystic ovary syndrome (PCOS).Methods: A prospective observational study was conducted with 75 infertile PCOS women. The demographic details, body mass index, menstrual patterns, and current medication related to infertility were noted. The collected data were statistically represented in terms of range, frequency tables, and standard deviation wherever appropriate.Results: A majority of the infertile PCOS women were aged 24–27 years with a mean age of 25.72±3.53 years, belonging to middle socioeconomic class (44%) and mostly found to be urban residents 68%. Most of the PCOS women were overweight (32%) and obese (21%) with irregular menstrual pattern (90.67%). In combination therapy, clomiphene citrate (CC) pre-treated with oral contraceptives (OC) (37.93%) was mostly given to obese PCOS patients followed by CC with metformin pre-administered with OC (31.03%), whilen on-obese PCOS patients were mostly administered CC with gonadotropins pre-treated with OC(44%). In single therapy, OC was mostly administered to both non-obese (90%) and obese PCOS patients (88.90%).Conclusion: This study concluded that most of the infertile PCOS women were overweight and obese, a major risk actor causing hyperandrogenicity. CC pre-treated with OC and metformin with CC pre-treated with OC were mostly prescribed to obese PCOS patients. Lifestyle modifications along with treatment are strongly recommended, especially in obese PCOS patients.

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Section: Discussioncontrasting

confidence: 75%

Prescription Pattern in Obese and Non-Obese Infertile Women With Polycystic Ovary Syndrome in a Tertiary Care Hospital

Avirah

Alias

Sajith

et al. 2018

Asian J Pharm Clin Res

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“…[10][11][12] In this study, the majority of the PCOS group were from a middle socioeconomic class (45%) as compared to non-PCOS control group (40%). The result of the study group is higher as compared to that reported by Dasgupta et al, in Hyderabad, India 13 wherein most of the PCOS women were from middle socioeconomic class (38.4%). However, there was no statistically significant relationship between socioeconomic status and both the PCOS and control groups p = 0.804).…”

Section: Ijifmcontrasting

confidence: 67%

Sociodemographic Characteristics and Clinical Presentation of Infertile Women with Polycystic Ovary Syndrome in a Tertiary Care Hospital

Nimbargi¹,

Mangalath²,

Alias³

et al. 2018

International Journal of Infertility &Amp; Fetal Medicine

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Background: Infertility has been an issue of concern especially for women for decades, and one of the identified etiological factors is polycystic ovary syndrome (PCOS) that impact on ovulation and conception.Aim: This study aims to study the sociodemographic characteristics and clinical presentationof infertile women with (POS). Materials and methods :In this prospective case-control study, out of 150 infertile patients 75 women served as PCOS group. The demographic details such as age, socioeconomic class, employment status residential area, Body mass index, menstrual patterns, clinical presentation, and infertility related lab values were noted.The collected data were statistically analyzed using the Chi-square test.Results: The prevalence of PCOS was high in the age group 24 to 27 years (37.33%), from middle socioeconomic class (45%), residing in urban areas (62.67%) and housewives (65.33%). Most of the PCOS patients were overweight (32%) and obese (21.33%) and showed statistical significance p = 0.021 and p = 0.021 respectively. Oligomenorrhea (54.67%) and amenorrhea (40%) were the commonly found clinical presentations. Weight gain (p = 0.000) and acne (p = 0.049) were found to be significant. Also, a significant relationship was seen for Luteinizing Hormone (LH) (p = 0.003) and Prolactin (p = 0.001) in both groups. Conclusion:In this study, the prevalence of PCOS was high in patients from a middle socio-economic class, residing in urban areas and obese patients. Oligomenorrhea was found to be the most common clinical presentation in PCOS patients. Furthermore, evidence of high LH and Prolactin levels were found that is known to be associated with hyperandrogenism in PCOS patients.

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“…The clinical characteristics of the participants have been described elsewhere 24 . However, given the relatively young patients with PCOS who were encountered at the clinics in Hyderabad (ranging from 19 to 35 years), none of the PCOS cases were found to be diabetic.…”

Section: Resultsmentioning

confidence: 99%

“…Although some studies have investigated the role of different candidate and GWAS genes in the T2DM pathophysiology 17 18 19 20 , there is a paucity of such studies from India with reference to PCOS. In the Indian context, most of the PCOS studies were confined to the clinical dimensions, and only a few genetic studies were undertaken 21 22 23 24 . Given the high prevalence of T2DM, particularly in Hyderabad 15 and because of its shared pathophysiology with PCOS, it is imperative to understand the aetiology of PCOS from the perspective of T2DM genes.…”

mentioning

confidence: 99%

Association of type 2 diabetes mellitus genes in polycystic ovary syndrome aetiology among women from southern India

Reddy¹,

Kommoju²,

Dasgupta³

et al. 2016

Indian J Med Res

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Background & objectives:Polycystic ovary syndrome (PCOS) is the most common reproductive endocrine disorder of premenopausal women. Given the phenotypic overlap between PCOS and type 2 diabetes mellitus (T2DM), this study was carried out to investigate whether genes implicated in T2DM were also involved in the susceptibility to PCOS among women from southern India.Methods:A total of 248 women with PCOS and 210 healthy women as controls were genotyped for a panel of 15 single nucleotide polymorphisms (SNPs) from the nine T2DM genes, such as TCF7L2, IGF2BP2, SLC30A8, HHEX, CDKAL1, CDKN2A, IRS1, CAPN10 and PPARG, on Sequenom MassARRAY platform.Results:None of the 15 SNPs were found to be significantly associated with PCOS after Bonferroni correction for multiple testing, either in the univariate or multivariate context. The cumulative effect of risk alleles observed with reference to T2DM was also not seen with reference to PCOS.Interpretation & conclusions:The nine T2DM genes considered in this exploratory study might not be the primary susceptibility factors for PCOS among Indian women. Our results supplement the lack of evidence of the association of T2DM genes with PCOS among the Chinese and Caucasians hinting at the possible universality of this pattern. Specifically designed comprehensive studies that include women with T2DM and PCOS are required to explore the precise role of the diabetes genes.

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The Role of Epistasis in the Etiology of Polycystic Ovary Syndrome among Indian Women: SNP‐SNP and SNP‐Environment Interactions

Cited by 26 publications

References 20 publications

Prescription Pattern in Obese and Non-Obese Infertile Women With Polycystic Ovary Syndrome in a Tertiary Care Hospital

Prescription Pattern in Obese and Non-Obese Infertile Women With Polycystic Ovary Syndrome in a Tertiary Care Hospital

Sociodemographic Characteristics and Clinical Presentation of Infertile Women with Polycystic Ovary Syndrome in a Tertiary Care Hospital

Association of type 2 diabetes mellitus genes in polycystic ovary syndrome aetiology among women from southern India

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