The role of epigenetic regulation in stress-induced depression

Zhang, Ke; Zhao, Mei; Lin, Wei

doi:10.3724/sp.j.1042.2016.01882

Cited by 1 publication

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“…Depression affects more than 300 million people worldwide, and its prevalence in China is close to 5% with a rapid increase in the last three decades 10-20%, and a gradual trend towards younger age groups. It is now believed that depression is the result of a combination of congenital genetic factors and acquired environmental factors [2] , such as the presence of polygenic disorders, and early childhood abuse which may cause the depressive episodes.…”

Section: Introductionmentioning

confidence: 99%

Epigenetic Alterations in Depression and Treatment Perspectives

Bai

2022

JCNR

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The global incidence of depression is progressively on the rise and tends to occur more in younger generations, however the pathogenesis of the disease is unclear. Meanwhile, epigenetics is a modification which produces heritable alterations in the DNA sequence, which ultimately manifest in phenotypic differences. It has been suggested that the onset and development of depression can be tentatively explained by the combination of epigenetic and environmental factors. This paper reviews epigenetic changes in depression in the context of environmental factors, including DNA methylation modifications, histone modifications, and non-coding RNA regulation. An epigenetic-based therapeutic outlook was also proposed in this paper, which initially elucidates the epigenetic mechanisms underlying the pathogenesis of depressions and provides a theoretical basis for the treatment of depression.

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Section: Introductionmentioning

confidence: 99%

Epigenetic Alterations in Depression and Treatment Perspectives

Bai

2022

JCNR

View full text Add to dashboard Cite

show abstract

The role of epigenetic regulation in stress-induced depression

Cited by 1 publication

References 0 publications

Epigenetic Alterations in Depression and Treatment Perspectives

Epigenetic Alterations in Depression and Treatment Perspectives

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