The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer

Nishikawa, Jun; Iizasa, Hisashi; Yoshiyama, Hironori; Nakamura, Munetaka; Saito, Mari; Sasaki, Sho; Shimokuri, Kanami; Yanagihara, Masashi; Sakai, Kazuhisa; Suehiro, Yutaka; Yamasaki, Takahiro; Sakaida, Isao

doi:10.3390/ijms18081606

Cited by 27 publications

(24 citation statements)

References 88 publications

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“…Epstein-Barr virus (EB virus) infection, which induces several epigenetic alterations in host genes, may be another carcinogenetic factor besides H. pylori-infected [19]. However, it is supposed that H. pylori-infected is essential for EB virus-induced carcinogenesis [20]. The pathogenesis of SRCCs without H. pylori-infected remains unclear and should be clarified in future research.…”

Section: Discussionmentioning

confidence: 99%

Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach

et al. 2020

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Background: Gastric cancer develops even in Helicobacter pylori(H. pylori)-uninfected patients and its typical histological feature is signet ring cell carcinoma (SRCC) within the mucosal layer. However, the biological characteristics of SRCC remain unclear. We aimed to clarify the pathological and genetic features of SRCC in H. pylori-uninfected patients. Methods: Seventeen H. pylori-uninfected patients with mucosal SRCCs were enrolled and their clinicopathological characteristics were compared with those of H. pylori-infected patients with mucosal SRCCs. Seven SRCCs without H. pylori-infected, including two invasive SRCCs, and seven H. pylori-infected SRCCs were subjected to a genetic analysis using next-generation sequencing. Results: H. pylori-uninfected patients with mucosal SRCCs revealed male dominancy and a significantly higher prevalence of smokers among them as compared with the H. pylori-infected patients with SRCC. A CDH1 mutation (frame shift indel) was detected in one H. pylori-uninfected cancer not only in the mucosal SRCC but also in the invasive portion. A TP53 mutation was detected in one SRCC without H. pylori-infected. In the control group, ARID1A and TP53 mutations were detected in one SRCC each. The C to A mutation, which is a characteristic smokinginduced mutation, was not found in any of the samples. Conclusions: Some SRCCs in H. pylori-uninfected patients may have a malignant potential similar to that of SRCCs in H. pylori-infected patients. Smoking may not be the main carcinogenic factor for the development of SRCCs among the H. pylori-uninfected patients.

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Section: Discussionmentioning

confidence: 99%

Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach

et al. 2020

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“…Therefore, there is a great interest in deciphering the molecular pathways associated with its progression and prognosis. Environment and lifestyles are general risk factors for GC, but interaction of diet with multiple genetic and epigenetic alterations also occur during GC development [ 2 , 3 , 4 , 5 ]. Proteomics provided consistent information in revealing proteome alterations associated with GC, dissected some of the mechanisms underlying gastric cancerogenesis, and enabled the identification of several diagnostic, prognostic, and predictive biomarkers [ 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma

Repetto

Maiero

Magris

et al. 2018

IJMS

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Elevated plasma fibrinogen levels and tumor progression in patients with gastric cancer (GC) have been largely reported. However, distinct fibrinogen chains and domains have different effects on coagulation, inflammation, and angiogenesis. The aim of this study was to characterize fibrinogen β chain (FGB) in GC tissues. Retrospectively we analyzed the data of matched pairs of normal (N) and malignant tissues (T) of 28 consecutive patients with GC at diagnosis by combining one- and two-dimensional electrophoresis (1DE and 2DE) with immunoblotting and mass spectrometry together with two-dimensional difference in gel electrophoresis (2D-DIGE). 1DE showed bands of the intact FGB at 50 kDa and the cleaved forms containing the fragment D at ~37–40 kDa, which corresponded to 19 spots in 2DE. In particular, spot 402 at ~50 kDa and spots 526 and 548 at ~37 kDa were of interest by showing an increased expression in tumor tissues. A higher content of spot 402 was associated with stomach antrum, while spots 526 and 548 amounts correlated with corpus and high platelet count (>208 × 109/L). The quantification of FGB and cleaved products may help to further characterize the interconnections between GC and platelet/coagulation pathways.

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“…It is widely believed that EBV contributes to the development of many diseases, including Burkitt’s lymphoma, Hodgkin’s lymphoma, diffuse large B-cell lymphoma, lymphoproliferative disorder in people with immunodeficiency [ 24 , 36 , 37 ], post-transplant lymphoproliferative disease, central nervous system lymphoma, non-Hodgkin lymphoma, oral hairy leukoplakia [ 38 ] and gastric cancer [ 24 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ].…”

Section: Oncogenic Viruses In Gastric Cancermentioning

confidence: 99%

“…When the ISH method is used, EBER1 signals are detected in the nuclei of gastric cancer cells [ 41 , 42 , 47 ]. In EBV positive stomach cancer (EBVaGC), all cancer cells carry the EBER1 gene [ 43 ].…”

Section: Oncogenic Viruses In Gastric Cancermentioning

confidence: 99%

The Double-Edged Sword Role of Viruses in Gastric Cancer

Niedźwiedzka-Rystwej

Grywalska

Hrynkiewicz

et al. 2020

Cancers

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Due to its high morbidity and mortality, gastric cancer is a topic of a great concern throughout the world. Major ways of treatment are gastrectomy and chemotherapy, unfortunately they are not always successful. In a search for more efficient therapy strategies, viruses and their potential seem to be an important issue. On one hand, several oncogenic viruses have been noticed in the case of gastric cancer, making the positive treatment even more advantageous, but on the other, viruses exist with a potential therapeutic role in this malignancy.

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The Role of Epigenetic Regulation in Epstein-Barr Virus-Associated Gastric Cancer

Cited by 27 publications

References 88 publications

Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach

Clinical and genomic characteristics of mucosal signet-ring cell carcinoma in Helicobacter pylori-uninfected stomach

Quantitative Proteomic Approach Targeted to Fibrinogen β Chain in Tissue Gastric Carcinoma

The Double-Edged Sword Role of Viruses in Gastric Cancer

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