The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General Anesthesia

Ma, Lin-Hui; Yan, Jing; Jiao, Xin-Hao; Zhou, Chenghua; Wu, Yuqing

doi:10.3389/fnmol.2022.877263

Cited by 6 publications

(1 citation statement)

References 71 publications

(89 reference statements)

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“…Studies have shown that exposure to GA can induce epigenetic changes in the developing brain, which may contribute to the long-term effects of GA on cognitive function. 45,46 Overall, while the exact mechanisms underlying the association between GA in young children and the risk of ID are not fully understood, preclinical studies have provided important insights into the potential mechanisms involved. Further research is imperative to comprehensively unravel these mechanisms and formulate effective strategies to alleviate the detrimental effects of GA on neurodevelopment in clinical practice.…”

Section: Discussionmentioning

confidence: 99%

Early Childhood General Anesthesia and Intellectual Disability: A Pediatric Cohort Study

Sun,

Chen,

et al. 2024

Preprint

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Background: The neurotoxicity of general anesthesia (GA) on the developing human brain is a topic of ongoing debate. In this study, we aimed to assess the association between GA exposure before the age of 3 and the risk of intellectual disability (ID). Methods:We enrolled individuals aged 0 to 3 years who underwent GA and were hospitalized for more than one day in Taiwan between January 2004 and December 2014. The study's final follow-up date was December 31, 2021. Results:Using propensity score matching, we identified 15,036 infants and toddlers (7,518 in the GA group and 7,518 in the no GA group). Cox regression analysis showed that the adjusted hazard ratio (aHR) for ID in the GA group was 2.38 (95% confidence interval [CI]: 1.94-2.91) compared to the no GA group. Children who underwent GA once and more than once had aHRs of ID of 1.98 (95% CI: 1.03-2.64) and 2.86 (95% CI: 1.52-3.11), respectively. The aHRs of ID for children who received GA for less than 3 hours and 3 hours or more were 1.86 (95% CI: 1.13-1.98) and 2.77 (95% CI: 1.44-2.92), respectively. The IRs of ID for the no GA group and GA group were 15.34 and 36.05 per 10,000 person-years, respectively. Conclusions: Our findings suggest that GA exposure before the age of 3 is associated with an increased risk of ID. Furthermore, age at first GA, duration of GA, and number of GA exposures are all significant risk factors for ID. Running Head: ID Risk in Children after GA

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Section: Discussionmentioning

confidence: 99%

Early Childhood General Anesthesia and Intellectual Disability: A Pediatric Cohort Study

Sun,

Chen,

et al. 2024

Preprint

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The role of epigenetic modification in postoperative cognitive dysfunction

Wu,

Lin,

Qiu

et al. 2023

Ageing Research Reviews

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Whole-brain characterization of apoptosis after sevoflurane anesthesia reveals neuronal cell death patterns in the mouse neonatal neocortex

Areias,

Sola,

Chastagnier

et al. 2023

Sci Rep

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In the last two decades, safety concerns about general anesthesia (GA) arose from studies documenting brain cell death in various pharmacological conditions and animal models. Nowadays, a thorough characterization of sevoflurane-induced apoptosis in the entire neonatal mouse brain would help identify and further focus on underlying mechanisms. We performed whole-brain mapping of sevoflurane-induced apoptosis in post-natal day (P) 7 mice using tissue clearing and immunohistochemistry. We found an anatomically heterogenous increase in cleaved-caspase-3 staining. The use of a novel P7 brain atlas showed that the neocortex was the most affected area, followed by the striatum and the metencephalon. Histological characterization in cortical slices determined that post-mitotic neurons were the most affected cell type and followed inter- and intracortical gradients with maximal apoptosis in the superficial layers of the posterodorsal cortex. The unbiased anatomical mapping used here allowed us to confirm sevoflurane-induced apoptosis in the perinatal period, neocortical involvement, and indicated striatal and metencephalic damage while suggesting moderate hippocampal one. The identification of neocortical gradients is consistent with a maturity-dependent mechanism. Further research could then focus on the interference of sevoflurane with neuronal migration and survival during development.

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The Role of Epigenetic Modifications in Neurotoxicity Induced by Neonatal General Anesthesia

Cited by 6 publications

References 71 publications

Early Childhood General Anesthesia and Intellectual Disability: A Pediatric Cohort Study

Early Childhood General Anesthesia and Intellectual Disability: A Pediatric Cohort Study

The role of epigenetic modification in postoperative cognitive dysfunction

Whole-brain characterization of apoptosis after sevoflurane anesthesia reveals neuronal cell death patterns in the mouse neonatal neocortex

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