The role of epidermal growth factor in prevention of oxidative injury and apoptosis induced by intestinal ischemia/reperfusion in rats

Reduction of relative centrifugal forces increases growth factor release within solid platelet-rich-fibrin (PRF)-based matrices: a proof of concept of LSCC (low speed centrifugation concept)

“…The accumulated EGF release showed significantly higher rates in the case of A-PRF and A-PRF+ compared with PRF at most time points, particularly on day 10. EGF has previously been described as promoting cell growth [21], enhancing keratinocyte migration [23], inhibiting apoptosis under hypoxic conditions [24], and supporting reepithelization and skin healing [25,26]. Additionally, EGF supports the healing process of chronic wounds [27], nonhealing chronic wounds and ulcers, which are, for example, observed in diabetic patients known to lack the necessary growth factors to maintain the healing process [28,29].…”

“…The growth factors VEGF, EGF and TGF-β1 were quantified for the released concentrations at each time point (6,24,48, 72 h, 7, and 10 days). Additionally, the accumulated growth factor quantities were calculated.…”

Epidermal growth factor, from gene organization to bedside

“…Through binding and activating EGFR, EGF itself or combined with other growth factors triggers many biological responses, including cell proliferation, differentiation and migration, which supporting a regulative role for the EGF/EGFR signaling in normal development [20] as well as pathophysiological events such as tissue repair including ulcer/wound healing [124–127], tissue repair after ischemia/reperfusion injury [128–130], etc. Exogenous EGF administration has shown beneficial antiapoptotic and antioxidant effects and has been found to reduce the tissue injury caused by IRI in different organs, such as heart [129], intestine [128], and kidney [130].…”

“…Exogenous EGF administration has shown beneficial antiapoptotic and antioxidant effects and has been found to reduce the tissue injury caused by IRI in different organs, such as heart [129], intestine [128], and kidney [130]. …”

Exposure assessment of epidermal growth factor to various tissues in mice after intravenous and subcutaneous administration

“…EGF is a potent mitogen involved in a range of developmental mechanisms such as growth, cell proliferation, regeneration, differentiation and wound repair [8]. The mitogenic, motogenic and cytoprotective actions of EGF are manifested by stimulation of migration of productive cells, accumulation of extracellular matrix, activation of myofibroblast and resurfacing of the injured area [9].…”