The role of epicardial and pericoronary adipose tissue radiomics in identifying patients with non-ST-segment elevation myocardial infarction from unstable angina

Wang, Zhenguo; Zhang, Jianhua; Zhang, Anxiaonan; Sun, Yu; Su, Mengwei; You, Hongrui; Zhang, Rongrong; Qi, Jin; Shi, Jinglong; Zhao, Di; Ma, Jingji; Li, Sen; Zhang, Libo; Yang, Benqiang

doi:10.1016/j.heliyon.2023.e15738

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…However, it was diminished amongst patients who had been put on statins or aspirin therapy and there was no such correlation regarding LCx [227]. Combining PCAT volume measured in CT around RCA, LAD, and LCx showed statistically significant potential in distinguishing NSTEMI from unstable angina pectoris in contrast to EAT volume [228]. RCA-PCAT attenuation assessed in CT positively correlated with total atherosclerotic plaque burden and amount of calcified plaque, however, there was no relationship regarding the prevalence of MI, cardiac death or revascularization [229].…”

Section: Pericoronary Adipose Tissue (Pcat)mentioning

confidence: 87%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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Epicardial adipose tissue (EAT) is a fat deposit surrounding the heart and located under the visceral layer of the pericardium. Due to its unique features, the contribution of EAT to the pathogenesis of cardiovascular and metabolic disorders is extensively studied. Especially, EAT can be associated with the onset and development of coronary artery disease, myocardial infarction and post-infarct heart failure which all are significant problems for public health. In this article, we focus on the mechanisms of how EAT impacts acute coronary syndromes. Particular emphasis was placed on the role of inflammation and adipokines secreted by EAT. Moreover, we present how EAT affects the remodeling of the heart following myocardial infarction. We further review the role of EAT as a source of stem cells for cardiac regeneration. In addition, we describe the imaging assessment of EAT, its prognostic value, and its correlation with the clinical characteristics of patients.

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Section: Pericoronary Adipose Tissue (Pcat)mentioning

confidence: 87%

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

Krauz,

Kempiński,

Jańczak

et al. 2024

IJMS

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“…Another study has also proven that radiomics features based on CCTA-derived PCAT can be used to distinguish between NSTEMI and UA. However, this study also noted certain limitations in the radiological model of epicardial adipose tissue for this task ( 295 ). Therefore, the radiomic features of PCAT based on CCTA can be used for the differential diagnosis of MI.…”

Section: Single-omics Approachesmentioning

confidence: 88%

From multi-omics approaches to personalized medicine in myocardial infarction

Zhan,

Tang,

et al. 2023

Front. Cardiovasc. Med.

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Myocardial infarction (MI) is a prevalent cardiovascular disease characterized by myocardial necrosis resulting from coronary artery ischemia and hypoxia, which can lead to severe complications such as arrhythmia, cardiac rupture, heart failure, and sudden death. Despite being a research hotspot, the etiological mechanism of MI remains unclear. The emergence and widespread use of omics technologies, including genomics, transcriptomics, proteomics, metabolomics, and other omics, have provided new opportunities for exploring the molecular mechanism of MI and identifying a large number of disease biomarkers. However, a single-omics approach has limitations in understanding the complex biological pathways of diseases. The multi-omics approach can reveal the interaction network among molecules at various levels and overcome the limitations of the single-omics approaches. This review focuses on the omics studies of MI, including genomics, epigenomics, transcriptomics, proteomics, metabolomics, and other omics. The exploration extended into the domain of multi-omics integrative analysis, accompanied by a compilation of diverse online resources, databases, and tools conducive to these investigations. Additionally, we discussed the role and prospects of multi-omics approaches in personalized medicine, highlighting the potential for improving diagnosis, treatment, and prognosis of MI.

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Enhancing cardiovascular risk stratification: Radiomics of coronary plaque and perivascular adipose tissue – Current insights and future perspectives

Corti,

Lo Iacono,

Ronchetti

et al. 2024

Trends in Cardiovascular Medicine

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The role of epicardial and pericoronary adipose tissue radiomics in identifying patients with non-ST-segment elevation myocardial infarction from unstable angina

Cited by 3 publications

References 37 publications

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

The Role of Epicardial Adipose Tissue in Acute Coronary Syndromes, Post-Infarct Remodeling and Cardiac Regeneration

From multi-omics approaches to personalized medicine in myocardial infarction

Enhancing cardiovascular risk stratification: Radiomics of coronary plaque and perivascular adipose tissue – Current insights and future perspectives

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