The role of eNOS and AGT gene polymorphisms in secondary pulmonary arterial hypertension in Romanian children with congenital heart disease

Self Cite

Section: Introductionmentioning

confidence: 99%

Predictors of Inadequate Mixing in Transposition of the Great Arteries — a Critical Neonatal Condition

Muntean

Toma²,

Togănel

2017

Self Cite

“…For instance, angiotensin gene polymorphism has been identified in secondary pulmonary arterial hypertension in children with congenital heart disease. 9 This kind of genetic inheritance has been described in several types of malignant arrhythmia and SCD in pediatric patients. Genetic testing and counseling may have a significant impact on the decision-making process with respect to indicating ICD therapy to children from families carrying an increased risk of SCD.…”

Section: Sudden Cardiac Death In Childhoodmentioning

confidence: 97%

Modern Technology for Prevention of Sudden Cardiac Death – a Clinical Update on Device Therapy in Children with Congenital Heart Diseases

Casu

2018

Sudden cardiac death in children is one of the most devastating conditions that can be encountered in acute cardiac care. Intracardiac device therapy, providing prompt and effective treatment in malignant ventricular arrhythmia or in severe conduction abnormalities, is a promising tool to reduce the incidence of this fatal condition. However, the implementation of device-based therapy in the pediatric population is currently limited by the lack of clinical studies on large number of subjects. As a result, indications for device therapy in pediatric patients are still unclear in many circumstances. There are also several particularities related to device implantation in pediatric age, such as the somatic growth leading to a mismatch between chamber size and lead length, or the difficulties of implantation technique in children with small body weight. This study aims to present an update on the current advantages and limitations of device-based therapy for treating severe malignant arrhythmia or conduction disorders in children at risk for sudden cardiac death.

“…Several genetic profiles have been identified as factors that influence the blood pressure homeostasis, such as endothelial nitric oxide synthase (eNOS), or polymorphisms encountered in the human angiotensinogen gene (AGT). 12,13…”

Section: Definitionsmentioning

confidence: 99%

An Updated Review of Hypertensive Emergencies and Urgencies

Makó

Ureche

Jeremiás

2018

A hypertensive crisis is an abrupt and severe rise in the arterial blood pressure (BP) occurring either in patients with known essential or secondary hypertension, or it may develop spontaneously. The most frequent cause for the severe and sudden increase in BP is inadequate dosing or stopping antihypertensive treatment in hypertensive patients. Severe hypertension can be defined as either a hypertensive emergency or an urgency, depending on the existence of organ damage. In hypertensive urgencies, there are no signs of acute end-organ damage, and orally administered drugs might be sufficient. In hypertensive emergencies, signs of acute end-organ damage are present, and in these cases, quickly-acting parenteral drugs must be used. The prompt recognition, assessment, and treatment of hypertensive urgencies and emergencies can decrease target organ damage and mortality. In this review, the definitions and therapeutic recommendations in a hypertensive crisis are presented in the light of the 2017 ACC/AHA Hypertension Guidelines.