The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses

Shen, Jing; Nakanishi, Toshio; Gu, Hong; Miyagawa‐Tomita, Sachiko; Wu, Gui-Rong; Momma, Kazuo; Nakazawa, Makoto

doi:10.1007/s003800200019

Cited by 15 publications

(8 citation statements)

References 20 publications

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“…However, there is a marked species difference in the degree of contribution of ET-1 to the O 2 -induced ductal contraction. Thus, reduction of O 2 -evoked contraction by ET-receptor antagonists is more marked in the lamb (12) and rat (41) than in the rabbit (41) or chicken (present work) DA. Whether maturational differences in the chicken DA response to O 2 and ET-1 are due to developmental changes in ET-1 receptor expression or in transductional pathways and the putative role of ET-1 in chicken DA closure warrant further investigation.…”

Section: Responsiveness To Oxygensupporting

confidence: 47%

“…Numerous findings implicate ET-1 as a regulator of mammalian DA tone and as a messenger in the constriction of the DA to O 2 (11-14, 34, 41, 43). Interference with ET-1 synthesis or action, whether achieved pharmacologically or through genetic manipulation, curtails the constrictor effect of O 2 (12,14,30,41). However, there is a marked species difference in the degree of contribution of ET-1 to the O 2 -induced ductal contraction.…”

Section: Responsiveness To Oxygenmentioning

confidence: 99%

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Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors

Ågren¹,

Cogolludo²,

Kessels³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

108

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The present study aimed to characterize the contractile reactivity of the chicken ductus arteriosus (DA) from the last stage of prenatal development and throughout the perinatal period. Isolated DA rings from 15-day, noninternally-pipped 19-day, and externally-pipped 21-day embryos were studied using myograph techniques. On embryonic day 15, the chicken DA did not respond to O 2 (0 to 21%), norepinephrine (NE), or phenylephrine (Phe) but contracted in response to high-K ϩ solution, the inhibitor of voltage-gated channels 4-aminopyridine, U-46619, and endothelin (ET)-1. These responses increased with advancing incubation age. Contractile responses to O 2, NE, and Phe were present in the 19-and 21-day embryo. Oxygen-induced contraction was restricted to the pulmonary side of the DA and was augmented by the nitric oxide synthase inhibitor N -nitro-L-arginine methyl ester and the soluble guanylate cyclase inhibitor 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one and reduced by the peptidic ET A and ETB-receptor antagonist PD-142,893. Transmural electrical stimulation of nerves, the nonselective cyclooxygenase (COX) inhibitor indomethacin, the COX-1 inhibitor valeryl salicylate, the COX-2 inhibitor nimesulide, the inhibitor of ATP-sensitive K ϩ channels glibenclamide, and the inhibitor of Ca 2ϩ -activated K ϩ channels tetraethylammonium did not cause contraction of the DA rings at any age. We conclude that transition to ex ovo life is accompanied by dramatic changes in chicken DA reactivity. At 0.7 incubation, excitation-contraction and pharmacomechanical coupling for several contractile agonists are already present, whereas the constrictor effects of O 2 and cathecolamines appear later in development and are located in the pulmonary side of the DA. ductus arteriosus; chicken embryo; potassium channels; oxygen sensing; cathecolamines.THE DUCTUS ARTERIOSUS (DA) is a vessel that connects the pulmonary artery to the aorta and provides, during the fetal life, a pulmonary-to-systemic diversion that shunts more than half of the right ventricle output away from the nonventilated lungs into the systemic circulation (43, 47). The main factors maintaining patency of the DA in utero are low O 2 tension, high levels of circulating PGE 2 , and locally produced PGE 2 and PGI 2 (24, 43). Failure of DA closure after birth is a common complication of premature delivery that is still presenting challenges in terms of diagnosis, assessment, and treatment options (43).Although the isolated DA is sensitive to a wide range of contractile agonists, the major factor actively stimulating contraction at birth is increasing O 2 tension, which has a profound effect on the DA, both directly and by modulating its response to vasodilators and vasoconstrictors (43). To constrict properly after birth, the DA prepares itself for this specific task from a quite early onset during development (3). This preparation is reflected by changes in responsiveness with advancing gestational age. These have been extensively characterized in numerous mammalian specie...

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Section: Responsiveness To Oxygensupporting

confidence: 47%

Section: Responsiveness To Oxygenmentioning

confidence: 99%

Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors

Ågren¹,

Cogolludo²,

Kessels³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

108

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“…Coincidentally, we have strengthened a scheme for oxygen sensing wherein CYP3A13, by operating as a catalytic element in a monooxygenase reaction, generates a signal for the activation of endothelin-1 (ET-1) (Coceani and Baragatti 2012). ET-1 is, therefore, seen as the ultimate effector for the contraction, and this role is supported by work from several laboratories, including ours (Coceani et al 1999;Takizawa et al 2000;Taniguchi et al 2001;Shen et al 2002;Ågren et al 2007). In a separate investigation, we have also proposed that the putative messenger linking CYP3A13 with ET-1 is the product of a joint action between arachidonic acid epoxygenase and 12(S)-lipoxygenase (Baragatti and Coceani 2011).…”

Section: Introductionmentioning

confidence: 83%

“…Furthermore, as in the case of the ductus (Coceani et al 1992;Takizawa et al 2000;Taniguchi et al 2001;Shen et al 2002;Ågren et al 2007), this oxygen response is liable to inhibition by an ET-1 antagonist. Hence, one may surmise that the scheme for the oxygen-induced contraction of the ductus, implicating CYP3A13 and ET-1, respectively, as sensor and effector (Coceani and Baragatti 2012), is also applicable to the Cyp3a13-transfected aortic muscle.…”

Section: Discussionmentioning

confidence: 99%

Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer

Ciofini

Scebba

Luin

et al. 2013

Can. J. Physiol. Pharmacol.

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We have previously shown that a cytochrome P450 (CYP450) hemoprotein from the 3A subfamily CYP3A13 for the mouse, serves as the sensor in the contraction of the ductus arteriosus in response to increased oxygen tension. In addition, we have identified endothelin-1 (ET-1) as the effector for this response. Here, we examined whether Cyp3a13 gene transfer confers oxygen sensitivity to cultured muscle cells from mouse aorta. Coincidentally, we determined whether the same hemoprotein is normally present in the vessel. Cyp3a13-transfected aortic cells responded to oxygen, whereas no significant response was seen in native cells or in cells transfected with an empty vector. Furthermore, this oxygen effect was curtailed by the ET-1/ETA receptor antagonist BQ-123. We also found that CYP3A13 occurs naturally in aortic tissue and its isolated muscle cells in culture. We conclude that CYP3A13 is involved in oxygen sensing, and its action in the transfected muscle cells of the aorta, as in the native cells of the ductus, takes place through a linkage to ET-1. However, the response of aortic muscle to oxygen, conceivably entailing the presence of CYP3A13 at some special site, is not seen in the native situation, and may instead unfold upon transfection of the parent gene.

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“…The DA constriction immediately after birth is triggered by: (a) an increase in oxygen tension, (b) a dramatic decline in circulating PGE 2 and a promotion of its degradation in the lung, (c) a decrease in the expression of PGE receptors in the DA wall, and (d) a decrease in blood pressure within the DA [7,8]. Endothelin-1, nitric oxide (NO), norepinephrine, acetylcholine, thromboxane A2, and bradykinin have been proposed as potential vasoreactive agents, in addition to oxygen and PGE [10][11][12][13][14][15][16][17][18][19].…”

Section: Overview Of the Mechanism Of Da Closurementioning

confidence: 99%

Role of Ion Channels in Ductus Arteriosus Closure

Akaike¹,

Minamisawa

2013

Human Genet Embryol

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The Ductus Arteriosus (DA) is a normal and essential fetal structure that connects the main pulmonary artery and the descending aorta. The DA constriction which occurs immediately after birth is triggered by: (a) an increase in oxygen tension, (b) a dramatic decline in circulating PGE 2 and a promotion of its degradation in the lung, (c) a decrease in the expression of PGE receptors in the DA wall and (d) a decrease in blood pressure within the DA. Ion channels play an essential role in this acute response that is known as functional DA closure. Oxygenation from fetal to neonatal circulation inhibits several potassium channels (voltage-dependent and ATP-dependent), which then leads to membrane depolarization. This depolarization triggers the activation of voltage-dependent calcium channels, and extracellular calcium then enters into the cytosol of smooth muscle cells of the DA. Calcium is also released from the sarcoplasmic reticulum, with a consequent supply provided through store-operated calcium channels. An increase in cytosolic calcium induces DA constriction. Ion channels also play a role in vascular remodeling of the DA, although this has not yet been extensively investigated. Voltage-dependent Land T-type calcium channels promote formation of intimal thickening through an increase in proliferation and migration of DA smooth muscle cells. Current medical treatment for patients with persistent patent DA is limited to cyclooxygenase inhibitors such as indomethacin and ibuprofen. A better understanding of the role of ion channels in vasoconstriction and vascular remodeling of the DA may encourage the design and development of novel pharmacological treatments for patients with patent DA. In this review, we focus on current knowledge on the roles of ion channels in the DA.

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The role of endothelin in oxygen-induced contraction of the ductus arteriosus in rabbit and rat fetuses

Cited by 15 publications

References 20 publications

Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors

Ontogeny of chicken ductus arteriosus response to oxygen and vasoconstrictors

Mouse aortic muscle cells respond to oxygen following cytochrome P450 3A13 gene transfer

Role of Ion Channels in Ductus Arteriosus Closure

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