The Role of Endothelin-B Receptors in Myocardial and Endothelial Reperfusion Injury After Heart Transplantation*

Szabó, Gábor; Bährle, Susanne; Fazekas, Levante; Vahl, C.-F.; Hagl, S.

doi:10.1055/s-2001-14338

Cited by 3 publications

(1 citation statement)

References 24 publications

(36 reference statements)

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“…In this context, both the ET A and ET B receptor have been proposed to mediate these effects (21,22). In contrast, a negative inotropic effect of ET-1 is frequently found in in vivo studies (23)(24)(25)(26). Interestingly, the inotropic response to ET-1 may change depending on the degree of cardiac stress.…”

Section: Discussionmentioning

confidence: 87%

Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock

Konrad

Oldner²,

Rossi³

et al. 2004

Critical Care Medicine

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In this porcine model of volume-resuscitated, endotoxemic shock, endothelin-receptor blockade with tezosentan improved cardiac performance. However, the effect was not sustained with higher doses of tezosentan, possibly due to reduced coronary perfusion pressure. These findings show differentiated, dose-dependent effects by dual endothelin receptor blockade on endotoxin-induced cardiovascular dysfunction.

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Section: Discussionmentioning

confidence: 87%

Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock

Konrad

Oldner²,

Rossi³

et al. 2004

Critical Care Medicine

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Expression of endothelin-1 system in a pig model of endotoxic shock

Forni

Mazzola

Ribeiro

et al. 2005

Regulatory Peptides

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Myocardial Protection with the Non-Selective Endothelin Receptor Antagonist L-753,037 Following Acute Coronary Artery Occlusion in the Dog

Krause

Clayton²,

Williams³

2004

Journal of Cardiovascular Pharmacology

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Efficacy of a new, potent non-selective endothelin antagonist, l-753037, was examined in a model of canine coronary artery occlusion and reperfusion to assess whether blockade of both ETA and ETB receptors would enhance or reduce myocardial ischemic injury. Instrumented dogs were randomized to receive vehicle (n = 9) or l-753037 (0.1 microg/kg/min, n = 9) by intracoronary infusion 30 minutes before a 90-minute LCx coronary artery occlusion and through 4 hours of reperfusion. After 4 hours of reperfusion, plasma ET-1 levels rose significantly in both groups: 24 +/- 3 fmol/ml in vehicle animals (P < 0.01) versus 42 +/- 5 fmol/ml with l-753037 (P < 0.05). Treatment with l-753037 normalized total LCx flow and regional myocardial flow after 4 hours of reperfusion in all regions. LCx flow was reduced 16% from pre-occlusion baseline (P = 0.45) with treatment compared with 35% with vehicle (P < 0.01). Endocardial flow in the risk region returned to baseline values with l-753037 treatment but was reduced approximately 50% in vehicle animals. l-753037 treatment was associated with a 38% reduction in infarct size (24.1 +/- 3.9% AAR with l-753037 treatment versus 38.7 +/- 3.1% with vehicle, P < 0.01). Thus, a non-selective endothelin antagonist provides significant myocardial protection primarily by improving regional myocardial flow distribution following reperfusion and demonstrated no detrimental effects associated with blockade of the ETB receptor.

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The Role of Endothelin-B Receptors in Myocardial and Endothelial Reperfusion Injury After Heart Transplantation*

Abstract: These results suggest that activation of the ET-B receptors contributes to reperfusion injury after cardiac preservation in a rat heart transplant model.

Cited by 3 publications

References 24 publications

Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock

Differentiated and dose-related cardiovascular effects of a dual endothelin receptor antagonist in endotoxin shock

Expression of endothelin-1 system in a pig model of endotoxic shock

Myocardial Protection with the Non-Selective Endothelin Receptor Antagonist L-753,037 Following Acute Coronary Artery Occlusion in the Dog

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