The role of endoscopy in the management of GERD

Muthusamy, V. Raman; Lightdale, Jenifer R.; Acosta, Ruben D.; Chandrasekhara, Vinay; Chathadi, Krishnavel V.; Eloubeidi, Mohamad A.; Fanelli, Robert D.; Fonkalsrud, Lisa; Faulx, Ashley L.; Khashab, Mouen A.; Saltzman, John R.; Shaukat, Aasma; Wang, Amy; Cash, Brooks D.; DeWitt, John M.

doi:10.1016/j.gie.2015.02.021

Cited by 106 publications

(43 citation statements)

References 64 publications

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“…Furthermore, guidelines specify that age more than 50 years is considered a high-risk indication for endoscopic evaluation of gastroesophageal reflux symptoms or to screen for Barrett's esophagus. [5][6][7][8][9] Likewise, national guidelines in other western countries recommend against urgent endoscopic evaluation of dyspepsia in patients aged less than 55 years. 10,11 This is concerning because studies suggest that the incidence of esophageal cancer among young patients is increasing.…”

Section: Perspectivementioning

confidence: 99%

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

Nobel

Curry

Gennarelli

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

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Background: Esophageal cancer is considered a disease of the elderly. Although the incidence of esophageal adenocarcinoma in young patients is increasing, current guidelines for endoscopic evaluation of gastroesophageal reflux disease and Barrett's esophagus include age as a cutoff. There is a paucity of data on the presentation and treatment of esophageal cancer in young patients. Most studies are limited by small sample sizes, and conflicting findings are reported regarding delayed diagnosis and survival compared with older patients.Methods: A retrospective cohort study was performed using the National Cancer Database between 2004 and 2015. Patients with esophageal adenocarcinoma were divided into quartiles by age (18-57, 58-65, 66-74, 75þ years) for comparison. Clinicopathologic and treatment factors were compared between groups.From the

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Section: Perspectivementioning

confidence: 99%

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

Nobel

Curry

Gennarelli

et al. 2020

The Journal of Thoracic and Cardiovascular Surgery

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“…Advancement of the newer, more elaborative high‐resolution endoscopy and narrow band imaging techniques, in comparison to conventional endoscopy, not only aids in diagnosis and defines management but can also play a role in transitioning toward targeted rather than random biopsy sampling in appropriate cases. However, endoscopic evidence of esophagitis is present in only approximately 30–50% of patients with a typical history of GERD, so a normal endoscopy does not exclude GERD . Kim et al .…”

Section: Clinical and Endoscopic Diagnosis Of Refluxmentioning

confidence: 99%

Relevance of histology in the diagnosis of reflux esophagitis

Tripathi

Streutker

Marginean

2018

Annals of the New York Academy of Sciences

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Reflux esophagitis is an important clinical diagnosis; however, the histologic findings can be nonspecific and overlap with other entities. Various benign changes can produce diagnostic difficulties for pathologists. In this review, the typical histologic findings of gastroesophageal reflux disease (GERD) of the esophagus are discussed, along with the issues relating to clinical correlation and technical aspects of endoscopic biopsies and specimen processing. The literature has been reviewed to discuss histologic definitions of GERD as well as current and developing controversies in the area of GERD. Histologic features are not entirely sensitive or specific for GERD. Awareness of these problems is essential; clinical and endoscopic information can be very useful in distinguishing GERD from other inflammatory lesions.

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“…As Stretta has been available since 2000, multiple studies of variable quality, methodology and outcome measures have been completed with some conflicting outcomes. Despite these inconsistencies, Stretta has been shown to be effective in three randomized trials and over 40 other prospective clinical studies [25]. In addition, the Society of American Gastrointestinal Endoscopic Surgeons supports Stretta as an effective treatment for refractory GERD patients [26].…”

Section: Strettamentioning

confidence: 99%

Bridging the Gap with Endoscopic (Endo luminal) Therapies for Gastro Esophageal Reflux Disease

Ertan¹

2016

JGPLD

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Currently, the procedure is usually performed under general anesthesia in the outpatient setting with possible short postprocedure inpatient observation. The EsophyX device (Figure 1, Figure 2) is placed on the endoscope. The endoscope is then inserted under direct visualization through the mouth and into the stomach. The endoscope is advanced and retroflexed to obtain direct visualization of the procedure. The tissue retractor is used to grasp the fundus, pull it into the EsophyX device, thereby recreating the gastro esophageal valve. If a hernia less than 2cm is present, the endoscope and device can be advanced to reduce the hernia. After the valve is created and hiatal hernia

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The role of endoscopy in the management of GERD

Cited by 106 publications

References 64 publications

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

Higher clinical suspicion is needed for prompt diagnosis of esophageal adenocarcinoma in young patients

Relevance of histology in the diagnosis of reflux esophagitis

Bridging the Gap with Endoscopic (Endo luminal) Therapies for Gastro Esophageal Reflux Disease

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