The role of endometrial thickness in predicting ectopic pregnancy after in vitro fertilization and the establishment of a prediction model

Liu, Jing; Kong, Hongjiao; Yu, Xiao‐Juan; Zhou, Ming-Sheng; Liu, Xiaoyang; Xin-mi, Liu; Zhang, Jianrui; Li, Yanli; Wu, Shanshan; Guan, Yichun

doi:10.3389/fendo.2022.895939

Cited by 7 publications

(8 citation statements)

References 26 publications

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“…Following this, mature oocytes (MII) were subjected to fertilization via intracytoplasmic sperm injection (ICSI). Embryos were cultured from pronuclear stage to cleavage stage in G1™ Plus (Vitrolife) after fertilization and then from cleavage stage to blastocyst stage in G-2™ Plus (Vitrolife) [ 25 ]. Embryo quality was evaluated based on previous literature [ 26 ], and day 3 embryos with a score of grade III or higher were designated as D3 available embryos in our institution.…”

Section: Methodsmentioning

confidence: 99%

Effects of chromosomal translocation characteristics on fertilization and blastocyst development — a retrospective cohort study

Wu,

Zhang,

Guan

et al. 2023

BMC Med Genomics

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Objective To determine the effect of different translocation characteristics on fertilization rate and blastocyst development in chromosomal translocation patients. Methods This retrospective cohort study was conducted at the Third Affiliated Hospital of Zhengzhou University From January 2017 to December 2022.All couples were diagnosed as reciprocal translocation or Robertsonian translocation by karyotype of peripheral blood lymphocytes test. After adjusting for confounding factors, the effect of chromosomal rearrangement characteristics, such as carrier sex, translocation type, chromosome length and break sites, on fertilization rate and embryo development were analysed separately using multiple linear regression. Results In cases of Robertsonian translocation (RobT), the carrier sex plays an independent role in fertilization rate, and the male carriers was lower than that of female carriers (76.16% vs.86.26%, P = 0.009). In reciprocal translocation (RecT), the carrier sex, chromosome types and break sites had no influence on fertilization rate, blastocyst formation rate (P > 0.05). However, patients with human longer chromosomal (chromosomes 1–5) translocation have a lower available blastocyst formation rate (Group AB vs. Group CD: 41.49%vs.46.01%, P = 0.027). For male carriers, the translocation types was an independent factor affecting the fertilization rate, and the RobT was the negative one (B = − 0.075, P = 0 0.009). In female carriers, we did not observe this difference (P = 0.227). Conclusions In patients with chromosomal translocation, the fertilization rate may be influenced by carrier sex and translocation type, chromosomes 1–5 translocation may adversely affect the formation of available blastocysts. Break sites have no role in fertilization and blastocyst development.

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Section: Methodsmentioning

confidence: 99%

Effects of chromosomal translocation characteristics on fertilization and blastocyst development — a retrospective cohort study

Wu,

Zhang,

Guan

et al. 2023

BMC Med Genomics

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“…The conventional gonadotrophin-releasing hormone agonist (GnRH-a) (Diphereline, lpsen, France) long protocols of our center were used for ovulation stimulation (8), and eggs were collected 36-38 h after human chorionic gonadotropin (hCG) injection.…”

Section: Controlled Ovarian Hyperstimulationmentioning

confidence: 99%

Clinical outcome analysis of frozen-thawed embryo transfer on Day 7

et al. 2022

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ObjectiveTo investigate the clinical outcomes of Day 7 (D7) frozen-thawed embryo transfer (FET) and to provide a reference value for clinical work.MethodsThis was a retrospective cohort study. Patients undergoing FET cycles in the Reproductive Medicine Center of the Third Affiliated Hospital of Zhengzhou University between December 2015 and January 2021 were included. According to the developmental stage of the embryos at transfer, the embryos were divided into three groups: Day (D) 5, D6 and D7 blastocysts. Group D7 was compared with Groups D5 and D6. Simultaneously, the preimplantation genetic testing (PGT) and non-PGT cycles in Group D7 were analyzed and compared. The main outcomes were the clinical pregnancy, live birth and miscarriage rates. The secondary outcomes were the implantation and euploidy rates.ResultsIn total, 5945, 4094 and 137 FET cycles were included in the D5, D6 and D7 groups, respectively. The clinical pregnancy rate was significantly lower in Group D7 than in Groups D5 (13.9% vs 62.9%, P <0.001) and D6 (13.9% vs 51.4%, P <0.001). Additionally, the live birth rate was significantly lower in Group D7 than in Groups D5 (7.3% vs 50.7%, P <0.001) and D6 (7.3% vs 40.5%, P <0.001). However, the miscarriage rate was significantly higher in Group D7 than in Groups D5 (47.4% vs 18.2%, P =0.001) and D6 (47.4% vs 20.6%, P =0.004). The clinical pregnancy and live birth rates for D7 blastocysts were significantly higher in the PGT group than in the non-PGT group (41.7% vs 13.9%, P=0.012; 33.3% vs 7.3%, P =0.003).ConclusionsD7 blastocyst transfer can yield a live birth rate that is lower than that for D5 and D6 blastocysts but has value for transfer. PGT for D7 blastocysts may reduce the number of ineffective transfers and improve the outcome of D7 blastocyst transfer, which can be performed according to a patient’s situation.

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“…Despite significant improvements in the incidence of EP with FET compared with fresh transfer (1%-2% [1,2] and 2%-8% [1,3] , respectively), methods to predict the incidence of EP in FET are not fully understood. Some studies have found that endometrial thickness (EMT) is an independent risk factor for EP in IVF/FET [4][5][6][7][8][9] ; however, studies have proposed different threshold levels of EMT, ranging from 7.6 to 12.0 mm. Thus, it may be important to identify the risk factors for EP and predict the endometrial characteristics associated with EP after ART.…”

Section: Introductionmentioning

confidence: 99%

“…Some studies have found that endometrial thickness (EMT) is an independent risk factor for EP in IVF/FET [4–9] ; however, studies have proposed different threshold levels of EMT, ranging from 7.6 to 12.0 mm. Thus, it may be important to identify the risk factors for EP and predict the endometrial characteristics associated with EP after ART.…”

Section: Introductionmentioning

confidence: 99%

Effect of endometrial thickness on the risk of ectopic pregnancy for frozen embryo transfer

Huang,

Zheng,

Wang

et al. 2023

Reproductive and Developmental Medicine

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Objective: Few studies have explored the suitability of endometrial thickness (EMT) as a predictor of ectopic pregnancy (EP) in frozen embryo transfer (FET) cycles. Our study aimed to investigate the association between EMT and EP and explore the cutoff value of EMT to predict EP. Methods: This retrospective cohort study included women aged 20 - 45 years undergoing FET between March 2015 and September 2021. The primary outcomes and measured variables were ectopic pregnancy and endometrial thickness, respectively. The threshold effect of EMT on EP was calculated based on a constructed smooth curve fitting. The patients were divided into two groups based on the threshold for comparison. A subgroup analysis was conducted to examine whether the relationship between EMT and EP remained consistent across the different subgroups. Additionally, a generalized linear model was used to analyze the interactions between the treatment factors and EMT in EP. Results: In total, 27,549 FET cycles were included, with 27,086 intrauterine and 463 ectopic pregnancies. The risk of EP in the EMT ≤ 8.7 mm group was 3.36 times higher than that in the EMT >8.7 mm group (OR: 3.36, 95% CI 2.57-4.05). Subgroup analysis further indicated that a thin EMT was a risk factor for EP, independent of other risks. We also noted that diminished ovarian reserve, tubal factor infertility, transfer of two embryos, or transfer of cleavage-stage embryos may further enhance the risk of EP in patients with thin endometrium. Conclusions: Thin endometrium was associated with an increased risk of EP. Patients with EMT less than 8.7 mm need close medical observation and management after embryo transfer. In addition, diminished ovarian reserve, tubal factor infertility, transfer of two embryos, or transfer of cleavage-stage embryos may significantly enhance the effect of a thin endometrium on the risk of EP.

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The role of endometrial thickness in predicting ectopic pregnancy after in vitro fertilization and the establishment of a prediction model

Cited by 7 publications

References 26 publications

Effects of chromosomal translocation characteristics on fertilization and blastocyst development — a retrospective cohort study

Effects of chromosomal translocation characteristics on fertilization and blastocyst development — a retrospective cohort study

Clinical outcome analysis of frozen-thawed embryo transfer on Day 7

Effect of endometrial thickness on the risk of ectopic pregnancy for frozen embryo transfer

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