The role of emotional inhibitory control in specific internet addiction – an fMRI study

Dieter, Julia; Hoffmann, Sabine; Mier, Daniela; Reinhard, Iris; Beutel, Martin; Vollstädt‐Klein, Sabine; Kiefer, Falk; Mann, Karl; Leménager, Tagrid

doi:10.1016/j.bbr.2017.01.046

Cited by 57 publications

(42 citation statements)

References 59 publications

(84 reference statements)

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“…The BIS-11 correlates of the FC alternations demonstrated that the impairment in the prefrontal-striatal circuits may have an impact on impulsive behavior of IGD subjects. Previous neuroimaging studies reported that functional impairment in the PFC regions was associated with the high impulsivity in IGD ( 37 ). The prefrontal-striatal circuits include a cognitive loop, which mainly connects the caudate and the putamen with prefrontal regions.…”

Section: Discussionmentioning

confidence: 97%

Resting-State Activity of Prefrontal-Striatal Circuits in Internet Gaming Disorder: Changes With Cognitive Behavior Therapy and Predictors of Treatment Response

et al. 2018

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Cognitive behavior therapy (CBT) is effective for the treatment of Internet gaming disorder (IGD). However, the mechanisms by which CBT improves IGD-related clinical symptoms remain unknown. This study aimed to discover the therapeutic mechanism of CBT in IGD subjects using resting-state functional magnetic resonance imaging (rsfMRI). Twenty-six IGD subjects and 30 matched healthy controls (HCs) received rsfMRI scan and clinical assessments; 20 IGD subjects completed CBT and then were scanned again. The amplitude of low-frequency (ALFF) values and the functional connectivity (FC) between the IGD group and the HC group were compared at baseline, as well as the ALFF values and FC before and after the CBT in the IGD group. Prior to treatment, the IGD group exhibited significantly increased ALFF values in the bilateral putamen, the right medial orbitofrontal cortex (OFC), the bilateral supplementary motor area (SMA), the left postcentral gyrus, and the left anterior cingulate (ACC) compared with the HC group. The HC group showed significantly increased FC values between the left medial OFC and the putamen compared with the IGD group, the FC values of IGD group were negatively associated with the BIS-11 scores before treatment. After the CBT, the weekly gaming time was significantly shorter, and the CIAS and BIS-II scores were significantly lower. The ALFF values in the IGD subjects significantly decreased in the left superior OFC and the left putamen, and the FC between them significantly increased after the CBT. The degree of the FC changes (ΔFC/Pre−FC) was positively correlated with the scale of the CIAS scores changes (ΔCIAS/Pre−CIAS) in the IGD subjects. CBT could regulate the abnormal low-frequency fluctuations in prefrontal-striatal regions in IGD subjects and could improve IGD-related symptoms. Resting-state alternations in prefrontal-striatal regions may reveal the therapeutic mechanism of CBT in IGD subjects.

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Section: Discussionmentioning

confidence: 97%

Resting-State Activity of Prefrontal-Striatal Circuits in Internet Gaming Disorder: Changes With Cognitive Behavior Therapy and Predictors of Treatment Response

et al. 2018

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“…For example, Ding et al () suggested that impaired function of the prefrontal cortex may relate to high impulsivity in adolescents with IA, which may contribute directly to the IA process. Dieter et al () revealed decreased left middle and superior temporal gyrus activation while experiencing socially anxious words in internet gaming addicts. Additionally, risk taking is related importantly to addictive behaviors (Panwar et al, ).…”

Section: Discussionmentioning

confidence: 99%

Random topology organization and decreased visual processing of internet addiction: Evidence from a minimum spanning tree analysis

Wang

Sun

et al. 2019

Brain and Behavior

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Objectives Internet addiction (IA) has been associated with widespread brain alterations. Functional connectivity (FC) and network analysis results related to IA are inconsistent between studies, and how network hubs change is not known. The aim of this study was to evaluate functional and topological networks using an unbiased minimum spanning tree (MST) analysis on electroencephalography (EEG) data in IA and healthy control (HC) college students. Methods In this study, Young's internet addiction test was used as an IA severity measure. EEG recordings were obtained in IA ( n = 30) and HC participants ( n = 30), matched for age and sex, during rest. The phase lag index (PLI) and MST were applied to analyze FC and network topology. We expected to obtain evidence of underlying alterations in functional and topological networks related to IA. Results IA participants showed higher delta FC between left‐side frontal and parieto‐occipital areas compared to the HC group ( p < 0.001), global MST measures revealed a more star‐like network in IA participants in the upper alpha and beta bands, and the occipital brain region was relatively less important in the IA relative to the HC group in the lower band. The correlation results were consistent with the MST results: higher IA severity correlated with higher Max degree and kappa, and lower eccentricity and diameter. Conclusions Functional networks of the IA group were characterized by increased FC, a more random organization, and a decrease of relative functional importance of the visual processing area. Taken together, these alterations can help us understand the influence of IA to brain mechanism.

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“…A recent study found decreased left middle and superior temporal gyrus activation during interference of socially anxious words in IGD, possibly indicating social anxiety ( 71 ). A meta-analysis concluded that individuals with IGD are more likely to exhibit impaired response inhibition ( 72 ).…”

Section: Brain Activationmentioning

confidence: 99%

An Update Overview on Brain Imaging Studies of Internet Gaming Disorder

Weinstein

2017

Front. Psychiatry

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There are a growing number of studies on structural and functional brain mechanisms underlying Internet gaming disorder (IGD). Recent functional magnetic resonance imaging studies showed that IGD adolescents and adults had reduced gray matter volume in regions associated with attention motor coordination executive function and perception. Adolescents with IGD showed lower white matter (WM) integrity measures in several brain regions that are involved in decision-making, behavioral inhibition, and emotional regulation. IGD adolescents had also disruption in the functional connectivity in areas responsible for learning memory and executive function, processing of auditory, visual, and somatosensory stimuli and relay of sensory and motor signals. IGD adolescents also had decreased functional connectivity of PFC-striatal circuits, increased risk-taking choices, and impaired ability to control their impulses similar to other impulse control disorders. Recent studies indicated that altered executive control mechanisms in attention deficit hyperactivity disorder (ADHD) would be a predisposition for developing IGD. Finally, patients with IGD have also shown an increased functional connectivity of several executive control brain regions that may related to comorbidity with ADHD and depression. The behavioral addiction model argues that IGD shows the features of excessive use despite adverse consequences, withdrawal phenomena, and tolerance that characterize substance use disorders. The evidence supports the behavioral addiction model of IGD by showing structural and functional changes in the mechanisms of reward and craving (but not withdrawal) in IGD. Future studies need to investigate WM density and functional connectivity in IGD in order to validate these findings. Furthermore, more research is required about the similarity in neurochemical and neurocognitive brain circuits in IGD and comorbid conditions such as ADHD and depression.

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The role of emotional inhibitory control in specific internet addiction – an fMRI study

Cited by 57 publications

References 59 publications

Resting-State Activity of Prefrontal-Striatal Circuits in Internet Gaming Disorder: Changes With Cognitive Behavior Therapy and Predictors of Treatment Response

Resting-State Activity of Prefrontal-Striatal Circuits in Internet Gaming Disorder: Changes With Cognitive Behavior Therapy and Predictors of Treatment Response

Random topology organization and decreased visual processing of internet addiction: Evidence from a minimum spanning tree analysis

An Update Overview on Brain Imaging Studies of Internet Gaming Disorder

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