The role of electrical coupling in generating and modulating oscillations in a neuronal network

Mouser, Christina; Bose, Amitabha; Nadim, Farzan

doi:10.1016/j.mbs.2016.05.001

Cited by 4 publications

(2 citation statements)

References 26 publications

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“…This may give a hint as to why the electrically coupled Si1/2/4 in Melibe can generate alternating bursts in curare, but not Si2 alone in Dendronotus. In a number of systems, electrical connections among inhibitory interneurons contribute to synchronization of activity [34][35][36][37][38][39]. Furthermore, modeling studies have pointed to complex roles of electrical coupling in rhythmogenesis [40,41].…”

Section: Different Neural Mechanisms For a Similar Motor Behaviormentioning

confidence: 99%

Artificial Synaptic Rewiring Demonstrates that Distinct Neural Circuit Configurations Underlie Homologous Behaviors

Sakurai

Katz

2017

Current Biology

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Behavioral homology is often assumed to involve similarity in underlying neuronal mechanisms. Here, we provide a counterexample where homologous behaviors are produced by neurons with different synaptic connectivity. The nudibranch molluscs Melibe leonina and Dendronotus iris exhibit homologous swimming behaviors, consisting of alternating left and right body flexions. The swim central pattern generators (CPGs) in both species are composed of bilaterally symmetric interneurons, which are individually identified and reciprocally inhibit their contralateral counterparts, contributing to left-right burst alternation in the swim motor patterns. In Melibe, the swim CPG contains two parts that interact to produce stable rhythmic bursting; one part is the primary half-center kernel, and the other part, which consists of a bilateral pair of neurons called Si3, regulates period length. The Dendronotus swim CPG is simpler, with Si3 being part of the primary half-center oscillator. Application of curare (d-tubocurarine) selectively blocked the Si3 synapses in both species. In Melibe, curare application caused the burst duration of the swim motor pattern to lengthen, whereas in Dendronotus, curare halted bursting altogether. In both species, replacing the curare-blocked Si3 synapses with artificial synapses using dynamic clamp restored the original rhythmic bursting, thereby affirming the roles of those synapses. The curare-impaired bursting in Dendronotus was also restored by rewiring the homologous neurons into a Melibe-like primary half-center oscillator configuration, indicating that the connectivity itself could account for species differences in circuit responses to curare. The results suggest that synaptic connectivity diverged during evolution while behavior was conserved.

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Section: Different Neural Mechanisms For a Similar Motor Behaviormentioning

confidence: 99%

Artificial Synaptic Rewiring Demonstrates that Distinct Neural Circuit Configurations Underlie Homologous Behaviors

Sakurai

Katz

2017

Current Biology

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“…One of those models, the so-called half-center oscillator (HCO) was one of the first models to mechanistically explain rhythmogenesis [48–50] and has been particularly influential. In this model, two non-rhythmic cells or groups of cells are coupled by mutual inhibitory connections that give rise to antiphasic rhythmicity in the presence of an excitatory drive [51]. …”

Section: Rhythm Generating Network and The Role Of Synaptic Inhibitionmentioning

confidence: 99%

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Ramirez

Dashevskiy²,

Marlin³

et al. 2016

Current Opinion in Neurobiology

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Rhythmicity is critical for the generation of rhythmic behaviors and higher brain functions. This review discusses common mechanisms of rhythm generation, including the role of synaptic inhibition and excitation, with a focus on the mammalian respiratory network. This network generates three phases of breathing and is highly integrated with brain regions associated with numerous non-ventilatory behaviors. We hypothesize that during evolution multiple rhythmogenic microcircuits were recruited to accommodate the generation of each breathing phase. While these microcircuits relied primarily on excitatory mechanisms, synaptic inhibition became increasingly important to coordinate the different microcircuits and to integrate breathing into a rich behavioral repertoire that links breathing to sensory processing, arousal, and emotions as well as learning and memory.

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Recording of the Breathing Pattern in the Test with Controlled Hyperventilation in Subjects with a Borderline Type Personality Disorder

et al. 2019

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The role of electrical coupling in generating and modulating oscillations in a neuronal network

Cited by 4 publications

References 26 publications

Artificial Synaptic Rewiring Demonstrates that Distinct Neural Circuit Configurations Underlie Homologous Behaviors

Artificial Synaptic Rewiring Demonstrates that Distinct Neural Circuit Configurations Underlie Homologous Behaviors

Microcircuits in respiratory rhythm generation: commonalities with other rhythm generating networks and evolutionary perspectives

Recording of the Breathing Pattern in the Test with Controlled Hyperventilation in Subjects with a Borderline Type Personality Disorder

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