The Role of Eicosanoids in Reproduction

Zahradnik, H. P.; Schäfer, Wolfgang; Neulen, Joseph; Wetzka, B.; Gaillard, T.; Tielsch, James M.; Casper, F.

doi:10.1002/9783527613625.ch8

Cited by 7 publications

(8 citation statements)

References 184 publications

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“…These mediators exert essential roles in many physiological and pathological conditions, such as neuroinflammation in neurodegenerative diseases, e.g., Alzheimer's disease, Parkinson's disease and Chorea Huntington, and furthermore, after brain injuries, which can initiate the onset of neurodegenerative dysfunctions. Neuroinflammatory conditions enhance the risk of neurological disorders, such as epilepsy [8][9][10][11].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

Lerner

Post

Loch

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

Lerner

Post

Loch

et al. 2017

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biolog

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“…Omega-3 fatty acids have a critical role in neurological activity and in depression, especially if inflammatory processes are implicated (Raison et al, 2006;Tassoni et al, 2008). The antidepressant activity of omega-3 fatty acids (in particular EPA) appears to occur via modulation of norepinephrine, dopamine and serotonin re-uptake, degradation, synthesis and receptor binding; anti-inflammatory effects; and the stabilization of the neuronal cell membrane (Mischoulon and Freeman, 2013).…”

Section: ……………………… Figure 1 About Here ……………………mentioning

confidence: 99%

“…The antidepressant activity of omega-3 fatty acids (in particular EPA) appears to occur via modulation of norepinephrine, dopamine and serotonin re-uptake, degradation, synthesis and receptor binding; anti-inflammatory effects; and the stabilization of the neuronal cell membrane (Mischoulon and Freeman, 2013). There is also evidence for the efficacy of EPA as an adjunct to SSRIs (Chalon, 2006;Tassoni et al, 2008;Williams et al, 2006).…”

Section: ……………………… Figure 1 About Here ……………………mentioning

confidence: 99%

Nutraceuticals for major depressive disorder- more is not merrier: An 8-week double-blind, randomised, controlled trial

Sarris

Byrne

Stough

et al. 2019

Journal of Affective Disorders

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 A combination nutraceutical treatment did not outperform placebo in treating symptoms of depression, and was in fact less effective  Genetic polymorphisms and BDNF levels were not related to treatment response  A very high placebo response rate may have warranted a placebo run-in design  Future research may focus on precision-based approaches tailoring treatment to deficiencies, neurochemical abnormalities, or pharmacogenetic differences

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“…Evidence supporting the role of prostanoids in the control of uterine contractility has been reported [1,2]. However, little is known about the fine mechanisms involved in the local changes affecting myometrial PG biosynthesis.…”

Section: Introductionmentioning

confidence: 98%

“…ing the uterus. Besides sex steroids, prostaglandins (PGs) appear as primary regulators of uterine functions during the entire reproductive cycle [1,2]. The complex transformations affecting myometrial physiology during pregnancy require the liberation of such locally acting factors.…”

Section: Introductionmentioning

confidence: 99%

Prostaglandin G/H Synthase (PGHS)-2 Expression in Bovine Myometrium: Influence of Steroid Hormones and PGHS Inhibitors1

Doualla-Bell

Guay

Bourgoin

et al. 1998

Biology of Reproduction

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Prostaglandins (PGs) are important mediators regulating uterine functions during the reproductive process. The objective of this study was to examine, in myocytes from the circular and longitudinal layers of bovine myometrium, the relative levels of mRNA and proteins corresponding to the gene expression of key enzymes (phospholipase A2; prostaglandin G/H synthase-1 [PGHS-1]; prostaglandin G/H synthase-2 [PGHS-2]; prostaglandin I2 synthase) involved in PG biosynthesis. We examined the influence of estradiol-17beta and progesterone on the expression and activity of these enzymes. Treatment of myocytes with progesterone (P4: 10 nM, 24 h) in the absence or presence of estradiol-17beta (E2: 1 nM, 72 h) suppressed PG biosynthesis by approximately 60% in both myometrial layers. No significant effect was observed after E2 treatment. The combined effect of E2 and P4 on PG accumulation was correlated with the modulation of PGHS-2 protein and mRNA levels in the two myometrial layers without affecting other enzymes of the PG cascade. Selective or nonselective inhibition of PGHS activity with CGP 28238 (PGHS-2-specific; a product from Ciba-Geigy: 6-[2, 4-difluorophenoxy]-5-methyl-sulfonylamino-1-indanone) or indomethacin (PGHS-1 and -2) reduced prostacyclin accumulation (measured as 6-keto-PGF1alpha in the culture medium) in a dose-dependent manner in the two myometrial layers. A significant inhibitory effect was obtained at a low concentration of indomethacin (1 nM, p < 0.05) compared to CGP 28238 (10 nM, p < 0. 05). In both myometrial layers, the maximal effect of indomethacin and/or CGP 28238 on PG accumulation was observed at 100 nM and represented 85% and 65% inhibition, respectively. In the presence of phorbol 12-myristate (100 nM), CGP 28238 (10 nM) significantly suppressed PGHS-2 mRNA level by 44.80 +/- 7.67% (p < 0.01) and 27.83 +/- 7.62% (p < 0.05) in the longitudinal and circular layer, respectively. In contrast, indomethacin did not have any significant effect. These data constitute the first quantitative analysis of key enzymes involved in PG biosynthesis in separated myometrial layers. Furthermore, the results provide interesting information on the CGP 28238 drug modulating both enzymatic activity and mRNA expression of PGHS-2.

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The Role of Eicosanoids in Reproduction

Cited by 7 publications

References 184 publications

Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

Targeting brain and peripheral plasticity of the lipidome in acute kainic acid-induced epileptic seizures in mice via quantitative mass spectrometry

Nutraceuticals for major depressive disorder- more is not merrier: An 8-week double-blind, randomised, controlled trial

Prostaglandin G/H Synthase (PGHS)-2 Expression in Bovine Myometrium: Influence of Steroid Hormones and PGHS Inhibitors1

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