The role of EEF1D in disease pathogenesis: a narrative review

Abstract

Objective: The purpose of this paper was to investigate the role and mechanism of EEF1D in various diseases, especially in tumorigenesis and development, and explore the possibility of EEF1D as a biological target.Background: EEF1D is a part of the EEF1 protein complex, which can produce four protein isoforms, of which three short isoforms are used as translation elongation factors. The three short isoforms play a role in anti-aging, regulating the cell cycle, and promoting the occurrence and development of malignant tumors, and the only long-form isoform plays a role in the development of the nervous system.Methods: We searched the PubMed and Web of Science databases for literature up to January 2021 using relevant keywords, including "EEF1D", "eukaryotic translation elongation factor 1 delta", "translation elongation factor", "translation elongation factor and cancer", and "translation elongation factor and nervous system disease". We then created an overview of the literature and summarized the results of the paper.Conclusions: Through the review of relevant articles, we found that EEF1D is obviously overexpressed in a variety of tumors, and can regulate the proliferation of tumor cells and tumor growth, as well as play a role in tumor invasion. EEF1D is likely to become a new biological target for tumor therapy and diagnosis.

Dynamic proximity interaction profiling suggests that YPEL2 is involved in cellular stress surveillance

“…Eukaryotic translation elongation factor 1 delta (EEF1D) with a predicted MM of 71.4 kDa is a subunit of the elongation factor‐1 complex and functions as a guanine nucleotide exchange factor by stimulating the exchange of GDP to GTP in EEF1A1 (Dewulf et al, 2022 ). ELAV like RNA binding protein 1 (ELAVL1), an RNA‐binding protein (RBP) with an estimated 36 kDa MM, binds to poly‐U and AU‐rich elements (AREs) in the 3′‐UTR of target mRNAs and increases their stability (Ma et al, 1996 ; H. Xu et al, 2021 ). ELAVL1 is also involved in SG maturation (Ma et al, 1996 ; H. Xu et al, 2021 ).…”

“…ELAV like RNA binding protein 1 (ELAVL1), an RNA‐binding protein (RBP) with an estimated 36 kDa MM, binds to poly‐U and AU‐rich elements (AREs) in the 3′‐UTR of target mRNAs and increases their stability (Ma et al, 1996 ; H. Xu et al, 2021 ). ELAVL1 is also involved in SG maturation (Ma et al, 1996 ; H. Xu et al, 2021 ). G3BP stress granule assembly factor 1 (G3BP1), with an estimated MM of 52 kDa, is an RBP and a key component of SG assembly (Kedersha et al, 2016 ; Wu & Xu, 2022 ).…”

Autoantibodies against eukaryotic translation elongation factor 1 delta in two patients with autoimmune cerebellar ataxia

“…Deletion of the long isoform in mice leads to seizures and abnormal behaviors (22). EEF1D has also been reported to be overexpressed in various tumors, such as glioblastoma, glioma, and lymphoma (23)(24)(25)(26). Additionally, there are eight pseudogenes of EEF1D in the human genome, and EEF1D pseudogene-derived proteins or short peptides have been reported to be correlated with a range of tumors and neurological diseases, such as breast carcinoma, ankylosing spondylitis, non-small cell lung cancer, and lymphoma (27).…”

Autoantibodies against eukaryotic translation elongation factor 1 delta (EEF1D) in two patients with autoimmune cerebellar ataxia

“…Deletion of the long isoform in mice leads to seizures and abnormal behaviors (10). EEF1D has also been reported overexpression in various tumors, such as glioblastoma, glioma, lymphoma (11)(12)(13)(14). Additionally, there are eight pseudogenes of EEF1D in human genome, EEF1D pseudogene-derived proteins or short peptides were reported correlated to a range of tumors and neurological diseases, such as breast carcinoma, ankylosing spondylitis, non-small cell lung cancer, lymphoma (15).…”