The role of eCIRP in bleomycin-induced pulmonary fibrosis in mice

Bolourani, Siavash; Sari, Ezgi; Wang, Ping

doi:10.1371/journal.pone.0266163

Cited by 3 publications

(1 citation statement)

References 73 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study we hypothesized that the extracellular form of cold-inducible RNA-binding protein (CIRP), i.e. eCIRP, a newly identified DAMP, may be a driver of COVID-19 associated respiratory failure as experimental studies have shown that it is an important mediator of sepsis induced acute lung injury (10) and bleomycin induced pulmonary fibrosis (11). Cellular stressors such as hypothermia and hypoxia are known to induce upregulation and release of eCIRP into the extracellular space and circulation (12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

et al. 2022

View full text Add to dashboard Cite

Uncontrolled release of damage-associated molecular patterns (DAMPs) is suggested to be a major trigger for the dysregulated host immune response that leads to severe COVID-19. Cold-inducible RNA-binding protein (CIRP), is a newly identified DAMP that aggravates inflammation and tissue injury, and induces respiratory failure in sepsis. Whether CIRP contributes to the pathogenesis of respiratory failure in COVID-19 has not yet been explored.AimTo investigate if the concentration of extracellular CIRP (eCIRP) in serum associates with respiratory failure and lung involvement by chest computed tomography (CT) in COVID-19.MethodsHerein we report a prospective observational study of patients with COVID-19 included at two University Hospitals in Sweden between April 2020 and May 2021. Serum from hospitalized patients in Örebro (N=97) were used to assess the association between eCIRP and the level of respiratory support and its correlation with pulmonary involvement on chest CT and inflammatory biomarkers. A cohort of hospitalized and non-hospitalized patients from Umeå (N=78) was used as an external validation cohort. The severity of disease was defined according to the highest degree of respiratory support; mild disease (no oxygen), non-severe hypoxemia (conventional oxygen or high-flow nasal oxygen, HFNO <50% FiO2), and severe hypoxemia (HFNO ≥50% FiO2, mechanical ventilation). Unadjusted and adjusted linear regression was used to evaluate peak eCIRP day 0-4 in respect to severity, age, sex, Charlson comorbidity score, symptom duration, and BMI.ResultsPeak eCIRP concentrations were higher in patients with severe hypoxemia and were independently associated with the degree of respiratory support in both cohorts (Örebro; p=0.01, Umeå; p<0.01). The degree of pulmonary involvement measured by CT correlated with eCIRP, rs=0.30, p<0.01 (n=97).ConclusionHigh serum levels of eCIRP are associated with acute respiratory failure in COVID-19. Experimental studies are needed to determine if treatments targeting eCIRP reduces the risk of acute respiratory failure in COVID-19.

show abstract

Section: Introductionmentioning

confidence: 99%

Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

et al. 2022

View full text Add to dashboard Cite

show abstract

Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways

Yao,

Zhao,

et al. 2024

International Immunopharmacology

View full text Add to dashboard Cite

Administration of Collagen Peptide Prevents the Progression of Pulmonary Fibrosis in Bleomycin-Treated Mice

Yoshihara,

Asatsuma,

Masuko

et al. 2023

Biologics

View full text Add to dashboard Cite

Collagen peptides (CPs) are food-derived peptides that possess a variety of bioactive properties. Our study investigates the effects of CP on pulmonary fibrosis in bleomycin (BLM)-treated mice. C57BL/6J mice were subcutaneously injected with BLM for two weeks followed by a three-week experimental diet containing 25 mg/g of CP derived from chicken feet. Supplementation with CP suppressed the increase in lung weight and disruption of lung architecture observed in mice treated with BLM. BLM-treated mice also exhibited higher hydroxyproline content and increased expression levels of type I and III collagen subunit genes in the lungs. CP supplementation exerted no effect on these collagen-related factors; however, it significantly suppressed the gene expression of fibronectin and inflammation-related molecules in the lungs of BLM-treated mice. These findings suggest that CP administration prevents the development of pulmonary fibrosis by acting as an anti-inflammatory agent.

show abstract

The role of eCIRP in bleomycin-induced pulmonary fibrosis in mice

Cited by 3 publications

References 73 publications

Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

Serum concentration of extracellular cold-inducible RNA-binding protein is associated with respiratory failure in COVID-19

Extracellular CIRP induces abnormal activation of fibroblast-like synoviocytes from patients with RA via the TLR4-mediated HDAC3 pathways

Administration of Collagen Peptide Prevents the Progression of Pulmonary Fibrosis in Bleomycin-Treated Mice

Contact Info

Product

Resources

About