The role of dust mite allergens in atopic dermatitis

Platts‐Mills, Thomas A.E.; Mitchell, E. B.; Rowntree, S.; Chapman, Martin D.; Wilkins, S.R.

doi:10.1111/j.1365-2230.1983.tb01776.x

Cited by 164 publications

(65 citation statements)

References 48 publications

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“…Platts-Mills et al [163] described prolonged improvement of atopic dermatitis in patients (aged 2-37 years) of whom six carried out regular bedroom cleaning and/or removal of carpets and soft furniture, three adopted diets free of milk or eggs, and one used both treatments. A further 20 out of 23 patients improved within 10 days of admission to hospital without changing their medical treatment.…”

Section: Atopic Dermatitismentioning

confidence: 99%

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

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Section: Atopic Dermatitismentioning

confidence: 99%

The control of allergens of dust mites and domestic pets: a position paper

Colloff

Ayres²,

Carswell

et al. 1992

Clin Experimental Allergy

236

112

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“…The activity of AD can also be influenced by allergens. Exposure to environmental allergens may aggravate the eczema by inhalation [12][13][14] or skin contact [15], and an improvement of the skin lesions can be seen after allergen avoidance [16][17][18]. Immunological evidence supporting the significance of allergen exposure comes from the presence of elevated serum IgE levels to aeroallergens, the binding of IgE to antigen presenting cells in the skin [19], and the presence of allergen specific T-cells in lesional AD skin [20,21].…”

mentioning

confidence: 99%

Bronchial and skin reactivity in asthmatic patients with and without atopic dermatitis

Brinkman¹,

Raaijmakers²,

Bruijnzeel-Koomen³

et al. 1997

Eur Respir J

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It is unclear whether the presence and severity of atopic dermatitis (AD) is predictive for the occurrence and severity of early and late asthmatic responses to inhaled allergens. The aim of this study was to compare the bronchial effects of allergen inhalation challenge in allergic asthma (AA) and atopic dermatitis.We therefore studied these responses in: nine patients with mild-to-moderate AA without AD; eight patients with mild-to-moderate AA and mild AD; eight patients with severe AD and mild AA; and eight patients with severe AD without AA. Allergen challenge was performed by inhaling doubling doses until the dose provoking a 20% fall in forced expiratory volume in one second (PC20) was reached. The late asthmatic reaction (LAR) was defined as a fall of >20% in peak expiratory flow (PEF) between 3 and 8 h after the challenge.All but four of the patients with severe AD without AA developed an early asthmatic response (EAR). A LAR was seen in all patients with severe AD and mild AA, in four patients with mild AD and mild-to-moderate AA, and in three patients with mild-to-moderate AA without AD. The LAR was most pronounced in patients with a combination of mild AA and severe AD. This could be explained, in part, by a decreased skin sensitivity in these patients, which made the Cockcroft formula for prediction of PC20 allergen less accurate in such patients.We conclude that patients with severe atopic dermatitis and mild asthma are at risk for developing pronounced late asthmatic responses after allergen exposure. This suggests that eosinophils activated in atopic dermatitis also predispose to airway inflammation.

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“…However, none of the skin lesions in AD has the histologic appearance of a classic immediate hypersensitivity reaction, and there has been no clear consensus that aeroallergens are important in the pathogenesis of AD. Nevertheless, several clinical studies have supported a role for aeroallergens, notably house dust mite (HDM) (2)(3)(4)(5). Careful HDM avoidance regimens have been associated with improvement of AD (6,7), and recently an association between moderate to severe atopic dermatitis and increased exposure to HDM in patients' homes has been .demonstrated (8).…”

mentioning

confidence: 99%

The role of contact allergy to aeroallergens in atopic dermatitis

Groot¹,

Young²

1989

Contact Dermatitis

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In some patients with atopic dermatitis (AD), delayed-type allergy to aeroallergens, such as house dust mite, can be demonstrated by patch testing. Positive patch tests can be expected only in patients with AD and, in them, only to aeroallergens to which type 1 reactions have also been demonstrated. In an as yet unknown number of such cases, aeroallergens appear to play a role in AD. Studies to date have varied too widely in experimental method and design to allow more definite conclusions to be drawn. It is essential that future studies are standardised with regard to patch test system and designed to include adequate controls and assessment of relevance.

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The role of dust mite allergens in atopic dermatitis

Cited by 164 publications

References 48 publications

The control of allergens of dust mites and domestic pets: a position paper

The control of allergens of dust mites and domestic pets: a position paper

Bronchial and skin reactivity in asthmatic patients with and without atopic dermatitis

The role of contact allergy to aeroallergens in atopic dermatitis

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