The Role of Dual-Time Combined 18-Fluorideoxyglucose Positron Emission Tomography and Computed Tomography in the Staging and Restaging Workup of Locally Advanced Rectal Cancer, Treated With Preoperative Chemoradiation Therapy and Radical Surgery

Capirci, Carlo; Rubello, Domenico; Pasini, Felice; Galeotti, F.; Bianchini, E; Favero, G. Del; Panzavolta, R; Crepaldi, Giorgio; Rampin, Lucia; Facci, Enzo; Gava, Marcello; Banti, Elena; Marano, G.

doi:10.1016/j.ijrobp.2008.10.064

Cited by 96 publications

(72 citation statements)

References 32 publications

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“…Various PET-CT parameters have been investigated: mean standardized uptake value (SUVmean), maximum SUV (SUVmax), ΔSUVmax (SUVmax-pre -SUVmaxpost), response index [RI, (SUV pre -SUV post )/SUV pre ), metabolic tumor volume (MTV), ΔMTV% (MTV pre -MTV post )/MTV pre , visual response assessment (VRA), and total lesion glycolysis (TLG, SUVmean × MTV) ( Table 2) (19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32). These studies were able to establish a correlation between PET-CT results and CRT response (22)(23)(24)(25)(26)(27)(28)(29)(30). Most studies used several parameters but found just one or two parameters correlated with CRT response (21)(22)(23)(24)(25)(26)(27).…”

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

“…These studies were able to establish a correlation between PET-CT results and CRT response (22)(23)(24)(25)(26)(27)(28)(29)(30). Most studies used several parameters but found just one or two parameters correlated with CRT response (21)(22)(23)(24)(25)(26)(27). Kim et al used SUVmaxpre, SUVmax-post, ΔSUVmax and RI to assess tumor response.…”

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

“…Therefore, before ADC can be used as a predictor clinically, large cohort studies are needed. Capirci et al (25) Martoni et al (26) Chennupati et al (27) Kim et al (28) Maffione et al (29) Everaert et al (32) No. SUVmax-post was a significant factor for prediction of downstaging and pCR (28).…”

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

“…However, SUV can be influenced by the nuclear medicine physicians and acquisition protocols, the reproducibility was poorer than those of RI and the percentage differences. Two studies revealed the mean RI was significantly higher in responders than in nonresponders and concluded that RI may be best for assessing the CRT response (25,27). A meta-analysis derived a threshold for RI of 36-52% for predicting response to CRT with a sensitivity and specificity of 86% and 80%, respectively.…”

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

“…Over the past decades lots of PET-CT parameters have been implemented to assess the CRT response in LARC. RI might be the best parameter for response assessment, especially acquired during therapy (25)(26)(27). The percentage differences in SUV between pre-and post-CRT, especially %ΔSUVmean, can be considered as valuable markers and worth further study (32).…”

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

See 4 more Smart Citations

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Meng

Huang

Wang

et al. 2014

BST

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Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

Section: Positron Emission Tomography-computed Tomography (Pet-ct)mentioning

confidence: 99%

See 3 more Smart Citations

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Meng

Huang

Wang

et al. 2014

BST

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Positron Emission Tomography

Sham

Matesan

Park

et al. 2015

Yamada' S Textbook of Gastroenterology

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Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation

Perez

Habr‐Gama²,

Gama-Rodrigues³

et al. 2011

Cancer

112

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BACKGROUND: Neoadjuvant chemoradiation (CRT) therapy may result in significant tumor regression in patients with rectal cancer. Patients who develop complete tumor regression have been managed by treatment strategies that are alternatives to standard total mesorectal excision. Therefore, assessment of tumor response with positron emission tomography/computed tomography (PET/CT) after neoadjuvant treatment may offer relevant information for the selection of patients to receive alternative treatment strategies. METHODS: Patients with clinical T2 (cT2) through cT4NxM0 rectal adenocarcinoma were included prospectively. Neoadjuvant therapy consisted of 54 grays of radiation and 5-fluorouracil-based chemotherapy. Baseline PET/CT studies were obtained before CRT followed by PET/CT studies at 6 weeks and 12 weeks after the completion of CRT. Clinical assessment was performed at 12 weeks after CRT completion. PET/CT results were compared with clinical and pathologic data. RESULTS: In total, 99 patients were included in the study. Twenty-three patients were complete responders (16 had a complete clinical response, and 7 had a complete pathologic response). The PET/CT response evaluation at 12 weeks indicated that 18 patients had a complete response, and 81 patients had an incomplete response. There were 5 false-negative and 10 false-positive PET/CT results. PET/CT for the detection of residual cancer had 93% sensitivity, 53% specificity, a 73% negative predictive value, an 87% positive predictive value, and 85% accuracy. Clinical assessment alone resulted in an accuracy of 91%. PET/CT information may have detected misdiagnoses made by clinical assessment alone, improving overall accuracy to 96%. CONCLUSIONS: Assessment of tumor response at 12 weeks after CRT completion with PET/ CT imaging may provide a useful additional tool with good overall accuracy for the selection of patients who may avoid unnecessary radical resection after achieving a complete clinical response.

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The Role of Dual-Time Combined 18-Fluorideoxyglucose Positron Emission Tomography and Computed Tomography in the Staging and Restaging Workup of Locally Advanced Rectal Cancer, Treated With Preoperative Chemoradiation Therapy and Radical Surgery

Cited by 96 publications

References 32 publications

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Prediction of response to preoperative chemoradiotherapy in patients with locally advanced rectal cancer

Positron Emission Tomography

Accuracy of positron emission tomography/computed tomography and clinical assessment in the detection of complete rectal tumor regression after neoadjuvant chemoradiation

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