The role of dopamine in the locomotor stimulant effects and tolerance to these effects of caffeine

Powell, Kelly R.; Iuvone, P. Michael; Holtzman, Stephen G.

doi:10.1016/s0091-3057(01)00497-x

Cited by 34 publications

(20 citation statements)

References 41 publications

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“…Our experiments also confirmed that a motor activating dose of caffeine did not alter endogenous CART peptide levels in the NAc, corroborating a previous report (Cho et al , 2015). Our results replicated other results showing that caffeine exerts a biphasic (an inverted ‘U’-shaped) dose-response curve on LMA (Antoniou et al , 1998, Collins et al , 2010, Cook and Beardsley, 2003, El Yacoubi et al , 2000, File et al , 1988, Garrett and Holtzman, 1994, Halldner et al , 2004, Kaplan et al , 1992, Kuzmin et al , 2006, Marin et al , 2011, Powell et al , 2001, Rhoads et al , 2011, Solinas et al , 2002, Svenningsson et al , 1995, Zhang et al , 2011), and buttress other studies that show that intra-NAc CART peptide blunts cocaine-mediated LMA (Jaworski et al , 2003, Job et al , 2012, Job et al , 2014, Job et al , 2013). …”

Section: Discussionsupporting

confidence: 90%

Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism

Job

2016

Pharmacology Biochemistry and Behavior

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Much evidence suggests that intra-nucleus accumbens (NAc) CART peptide (CART 55-102) injection inhibits locomotor activity (LMA) when there is an increase in the release and activity of dopamine (DA) in the NAc. However, this hypothesis has not been fully tested. One way to examine this is to determine if there is a lack of effect of intra-NAc CART peptide on LMA that does not involve increases in DA release in the NAc. Several studies have suggested that caffeine-induced LMA does not involve extracellular DA release in the NAc core. Therefore, in this study, we have examined the effect of injections of CART peptide (2.5 μg) into the NAc core on the locomotor effects of caffeine in male Sprague-Dawley rats. Several LMA relevant doses of caffeine were used (0, 10, 20 mg/kg i.p.), and an inverted U response curve was found as expected. We determined, in the same animals, that intra-NAc CART peptide had no effect on caffeine induced LMA whereas it blunted cocaine-mediated LMA, as shown by other reports. We also extended a previous observation in mice by showing that at a LMA activating dose of caffeine there is no alteration of CART peptide levels in the NAc of rats. Our study supports the hypothesis that the inhibitory effects of CART peptide in the NAc may be exerted only under conditions of increased extracellular DA release and activity in this region. Our results also suggest that intra-NAc CART 55-102 does not generally inhibit increases in LMA due to all drugs, but has a more specific inhibitory effect on dopaminergic neurotransmission.

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Section: Discussionsupporting

confidence: 90%

Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism

Job

2016

Pharmacology Biochemistry and Behavior

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“…Some changes in the A 1 -A 2A heteromers (Ciruela et al 2006), the tolerance to the effects of A 1 receptor blockade (Karcz-Kubicha et al 2003), specific gene expression alterations in the striatum (Svenningsson et al 1999), the pushed-up GABAergic activity in the brain (Mukhopadhyay and Poddar 1998) and changes in dopamine receptors (Powell et al 2001) were proposed as underlying mechanisms for this process.…”

Section: R a F Tmentioning

confidence: 99%

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

Caravan

Berghian

Moldovan

et al. 2016

Can. J. Physiol. Pharmacol.

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Menopause is accompanied by enhanced oxidative stress and behavioral changes, effects attenuated by antioxidants. The aim of this study was to evaluate the effects of caffeine on behavior and oxidative stress in an experimental model of menopause. Female rats were divided in: sham-operated (CON), sham-operated and caffeine-treated (CAF), ovariectomized (OVX), ovariectomized and caffeinetreated (OVX+CAF). Caffeine (6 mg/kg) and vehicle were administered for 21 days (subchronic) and 42 days (chronic), using 2 experimental subsets. Behavioral tests and oxidative stress parameters in the blood, whole brain and hippocampus were assessed. The subchronic administration of caffeine decreased the lipid peroxidation and improved the antioxidant defense in the blood and brain. The GSH/GGSG ratio in the brain was improved by chronic administration, with reduced activities of antioxidant enzymes and enhanced nitric oxide and malondialdehyde levels. In particular, the lipid peroxidation in the hippocampus decreased in both experiments. The rats became hyperactive after 21 days of treatment, but no effect was observed after chronic administration. In both experimental subsets, caffeine had anxiolytic effects as tested in EPM. The administration of low doses of caffeine, for a short period of time, may be a new therapeutic approach to modulating the oxidative stress and anxiety in menopause.

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“…With caffeine included initially in the drinking water, adolescent rats consumed caffeine at a level within the upper range of what we 32 and others, for example, 48,49 have reported previously. Caffeine consumption normalized to body weight is relatively high, which is important because the generally smaller body size of children and adolescent humans leads similarly to higher doses of caffeine at levels of consumption comparable to adults.…”

mentioning

confidence: 70%

A Pattern of Adolescent Caffeine Consumption that Reduces Alcohol Withdrawal Severity

Pitchon

Zook

Rhoads

2013

Journal of Caffeine Research

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Background: Adolescent Long-Evans rats consume relatively high levels of an alcohol-containing liquid diet and show strong withdrawal responses after chronic alcohol consumption. Adolescent rats also show strong adaptive responses to chronic caffeine. Methods: The present study has used this model to investigate caffeine-alcohol co-use with caffeine administered to adolescent rats with and before an alcohol-containing liquid diet. There were four age-matched treatment groups (minimum of 12 rats per group): alcohol alone, alcohol administered with caffeine, caffeine administered before alcohol and caffeine, and caffeine administered before alcohol alone. Subsequent alcohol withdrawal severity was scored on a 4-point scale. Results: Followed through 3 weeks of co-administration, the presence of caffeine with alcohol in the liquid diet had no effect on the severity of subsequent alcohol withdrawal symptoms. After one week of alcohol consumption, withdrawal severity was modest, but it increased significantly by weeks 2 and 3. The same pattern was recorded for rats that were co-administered caffeine with alcohol. In contrast, administration of caffeine before the alcohol-containing diet significantly reduced the severity of alcohol withdrawal. Evidence of adaptive changes to the chronic caffeine pretreatment came in the form of decreased motor behavior during caffeine withdrawal and tolerance to the motor-activating effects of caffeine challenge. Caffeine pretreatment was effective only if caffeine was also included with alcohol in the liquid diet. Conclusion: The results present a pattern of caffeine consumption that can influence adolescent alcohol withdrawal severity and potentially mask this physical symptom of alcohol dependency.

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The role of dopamine in the locomotor stimulant effects and tolerance to these effects of caffeine

Cited by 34 publications

References 41 publications

Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism

Injection of Cocaine-Amphetamine Regulated Transcript (CART) peptide into the nucleus accumbens does not inhibit caffeine-induced locomotor activity: Implications for CART peptide mechanism

Modulatory effects of caffeine on oxidative stress and anxiety-like behavior in ovariectomized rats

A Pattern of Adolescent Caffeine Consumption that Reduces Alcohol Withdrawal Severity

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