The role of dominant premotor cortex in language: a study using intraoperative functional mapping in awake patients

Duffau, Hugues; Laurent, Césari; Denvil, Dominique; Gatignol, Peggy; Sichez, Nicole; Lopes, Manuel; Sichez, Jean‐Pierre; Effenterre, R. Van

doi:10.1016/s1053-8119(03)00203-9

Cited by 197 publications

(147 citation statements)

References 52 publications

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“…The unilateral activation pattern of VLPFC, SMA, and cerebellum could reflect subvocal rehearsal during the maintenance phase of the verbal and object WM tasks (21,39). Moreover, PMv showed stronger activation in the left hemisphere than in the right across all three investigated WM domains and in both age groups, a pattern consistent with the idea that left PMv plays a role in language (40). Because this unilateral lateralization pattern was not domainspecific for the verbal (and object) material but was also present in the spatial domain we assume that the function of a lateralized pattern of PMv during the maintenance phase of our study may reflect an unspecific preparation of the verbal report that was required during the response epochs of all three WM domains (40).…”

Section: Discussionsupporting

confidence: 77%

Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age

Höller-Wallscheid

Thier

Pomper

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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Elderly adults may master challenging cognitive demands by additionally recruiting the cross-hemispheric counterparts of otherwise unilaterally engaged brain regions, a strategy that seems to be at odds with the notion of lateralized functions in cerebral cortex. We wondered whether bilateral activation might be a general coping strategy that is independent of age, task content and brain region. While using functional magnetic resonance imaging (fMRI), we pushed young and old subjects to their working memory (WM) capacity limits in verbal, spatial, and object domains. Then, we compared the fMRI signal reflecting WM maintenance between hemispheric counterparts of various task-relevant cerebral regions that are known to exhibit lateralization. Whereas language-related areas kept their lateralized activation pattern independent of age in difficult tasks, we observed bilaterality in dorsolateral and anterior prefrontal cortex across WM domains and age groups. In summary, the additional recruitment of cross-hemispheric counterparts seems to be an age-independent domain-general strategy to master cognitive challenges. This phenomenon is largely confined to prefrontal cortex, which is arguably less specialized and more flexible than other parts of the brain. working memory | subjective task difficulty | lateralization | prefrontal cortex | cognitive aging

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Section: Discussionsupporting

confidence: 77%

Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age

Höller-Wallscheid

Thier

Pomper

et al. 2017

Proc. Natl. Acad. Sci. U.S.A.

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“…In particular, we are pleased to note that in their experience with 69 Chinese-speaking patients the authors confirmed a 79% probability of anarthria/speech arrest with stimulation of the left ventral premotor cortex (PMC), similar to our results (83%). These data support the crucial role of the ventral PMC for speech output, as suggested in previous reports (Duffau et al, 2003;van Geemen et al, 2014). Nonetheless, they also found a probability of 'speech arrest' in 32% of patients within the left pars opercularis (i.e.…”

Section: Broca's Area Is Not the Speech Output Regionsupporting

confidence: 91%

Reply: Probabilistic map of language regions: challenge and implication

Tate

Herbet

Moritz‐Gasser

et al. 2014

Brain

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“…Interestingly, a study using intraoperative functional mapping in awake patients showed that there may be a well-ordered functional organization in the PMA: The ventral part might be involved in planification of articulation, and the dorsal part might be involved in the naming network (Duffau et al, 2003). This functional organization pattern has not been discussed in terms of stuttering.…”

Section: The Neural Substrates For Atypical Execution Process In Stutmentioning

confidence: 99%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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a b s t r a c t a r t i c l e i n f oUsing an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable, multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to nonstuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about stuttering and to clinical applications.

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The role of dominant premotor cortex in language: a study using intraoperative functional mapping in awake patients

Cited by 197 publications

References 52 publications

Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age

Bilateral recruitment of prefrontal cortex in working memory is associated with task demand but not with age

Reply: Probabilistic map of language regions: challenge and implication

The neural substrates for atypical planning and execution of word production in stuttering

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