1995
DOI: 10.1016/s0962-8924(00)88932-1
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The role of DNA fragmentation in apoptosis

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Cited by 539 publications
(329 citation statements)
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“…PrI staining, a widely used marker of necrotic death, cannot discriminate between primary necrosis and secondary necrosis in neurones that have undergone, perhaps simultaneously, an apoptotic death programme. It has been suggested that manipulations capable of blocking cell death (by using agents such as cycloheximide, actinomycin D, or ATA) are the most powerful methods of identifying apoptosis (Choi, 1996) and also that several criteria must be considered in the delineation of the death process (Bortner et al, 1995). For these reasons, a pragmatic view has been taken and the death described in this article has been called necrotic-or apoptotic-like, based on the morphological and biochemical resemblances to these respective pathways.…”
Section: Figurementioning
confidence: 99%
“…PrI staining, a widely used marker of necrotic death, cannot discriminate between primary necrosis and secondary necrosis in neurones that have undergone, perhaps simultaneously, an apoptotic death programme. It has been suggested that manipulations capable of blocking cell death (by using agents such as cycloheximide, actinomycin D, or ATA) are the most powerful methods of identifying apoptosis (Choi, 1996) and also that several criteria must be considered in the delineation of the death process (Bortner et al, 1995). For these reasons, a pragmatic view has been taken and the death described in this article has been called necrotic-or apoptotic-like, based on the morphological and biochemical resemblances to these respective pathways.…”
Section: Figurementioning
confidence: 99%
“…The initial dogma was that Zn directly inhibited: (1 ) Ca 2ϩ /Mg 2ϩ -dependent endonucleases that were responsible for DNA fragmentation (27); (2 ) the activity of caspase-3, a critical protease in apoptosis (28); or (3 ) the processing of caspase-3 (12,29). In Fas-induced apoptosis, Zn does not inhibit cytochrome c release and thus acts somewhere between cytochrome c release and caspase-3 activation, perhaps via cytochrome c interactions with capase-9, Apaf-1, or Bcl-X L (30).…”
Section: Zinc and Cell Deathmentioning
confidence: 99%
“…173,174 Morphologically, it is characterised by cellular features such as membrane blebbing, cell shrinkage and chromatin condensation. 175 Intracellular events include various types of DNA fragmentation, 176 cytoskeletal alterations and protease activation (reviewed in reference 177). There is increasing evidence that apoptosis is a cellular default setting, which must be actively suppressed (for example by growth factors, anti-apoptotic proteins) for the cell to survive.…”
Section: Apoptosis In Prostate Cancermentioning
confidence: 99%