The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

Okui, Takafumi; Aoki-Nonaka, Yukari; Nakajima, Takako Eguchi; Yamazaki, Kazuhisa

doi:10.1007/s40496-014-0013-z

Cited by 13 publications

(12 citation statements)

References 97 publications

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“…During the development of periodontitis, various T helper subsets predominate in several stages [177]. B cells were observed to predominate in the progression of periodontal lesions, together with Th2 cell profiles [178, 179]. B cells and their antibodies act by preventing bacterial adhesion, by inactivating bacterial toxins, and by acting as opsonins for neutrophil phagocytosis [180].…”

Section: Immunological Mechanisms Triggered By P Gingivalis and Fmentioning

confidence: 99%

Immunological Pathways Triggered byPorphyromonas gingivalisandFusobacterium nucleatum: Therapeutic Possibilities?

Andrade

Almeida-da-Silva

Coutinho‐Silva

2019

Mediators of Inflammation

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Porphyromonas gingivalis(P. gingivalis) andFusobacterium nucleatum(F. nucleatum) are Gram-negative anaerobic bacteria possessing several virulence factors that make them potential pathogens associated with periodontal disease. Periodontal diseases are chronic inflammatory diseases of the oral cavity, including gingivitis and periodontitis. Periodontitis can lead to tooth loss and is considered one of the most prevalent diseases worldwide.P. gingivalisandF. nucleatumpossess virulence factors that allow them to survive in hostile environments by selectively modulating the host’s immune-inflammatory response, thereby creating major challenges to host cell survival. Studies have demonstrated that bacterial infection and the host immune responses are involved in the induction of periodontitis. The NLRP3 inflammasome and its effector molecules (IL-1βand caspase-1) play roles in the development of periodontitis. We and others have reported that the purinergic P2X7 receptor plays a role in the modulation of periodontal disease and intracellular pathogen control. Caspase-4/5 (in humans) and caspase-11 (in mice) are important effectors for combating bacterial pathogens via mediation of cell death and IL-1βrelease. The exact molecular events of the host’s response to these bacteria are not fully understood. Here, we review innate and adaptive immune responses induced byP. gingivalisandF. nucleatuminfections and discuss the possibility of manipulations of the immune response as therapeutic strategies. Given the global burden of periodontitis, it is important to develop therapeutic targets for the prophylaxis of periodontopathogen infections.

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Section: Immunological Mechanisms Triggered By P Gingivalis and Fmentioning

confidence: 99%

Immunological Pathways Triggered byPorphyromonas gingivalisandFusobacterium nucleatum: Therapeutic Possibilities?

Andrade

Almeida-da-Silva

Coutinho‐Silva

2019

Mediators of Inflammation

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“…eriodontitis is caused by periodontopathic bacteria and characterized by gingival inflammation, periodontal pocket formation, and alveolar bone resorption (1). Periodontal infection and inflammation are known to affect systemic health and are associated with diseases such as cardiovascular disease and diabetes mellitus (2)(3)(4).…”

mentioning

confidence: 99%

Microbiological and Clinical Effects of Sitafloxacin and Azithromycin in Periodontitis Patients Receiving Supportive Periodontal Therapy

Nakajima

Okui

Ito

et al. 2016

Antimicrob Agents Chemother

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“…Periodontitis is characterized by the inflammation and destruction of tooth‐supporting tissues, and results from the interaction between host defense mechanisms and periodontopathic bacteria that constitute dental plaque biofilm and penetrate gingival tissue . Human gingival epithelial cells (HGECs) provide a critical first line of defense against these bacteria, by not only serving as a physical barrier but also regulating the immune responses.…”

mentioning

confidence: 99%

Resveratrol suppresses the inflammatory responses of human gingival epithelial cells in a SIRT1 independent manner

Minagawa

Okui

Takahashi

et al. 2014

J of Periodontal Research

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The Role of Distinct T Cell Subsets in Periodontitis—Studies from Humans and Rodent Models

Cited by 13 publications

References 97 publications

Immunological Pathways Triggered byPorphyromonas gingivalisandFusobacterium nucleatum: Therapeutic Possibilities?

Immunological Pathways Triggered byPorphyromonas gingivalisandFusobacterium nucleatum: Therapeutic Possibilities?

Microbiological and Clinical Effects of Sitafloxacin and Azithromycin in Periodontitis Patients Receiving Supportive Periodontal Therapy

Resveratrol suppresses the inflammatory responses of human gingival epithelial cells in a SIRT1 independent manner

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