The Role of Diffusion-Weighted MRI in the Characterization of Musculoskeletal Soft Tissue Tumors

Nassif, Mohamed Amin; Rahim, Susan A. Abdul; Hussien, Rana Z.

doi:10.12816/0040619

Cited by 4 publications

(4 citation statements)

References 8 publications

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“…In our study, DWA was done for all cases most of the mass lesion show restricted diffusion (23 patients)76.67%.and ADC was measured for all cases, the mean ADC value of benign and malignant soft tissue tumors was 1.802 + 0. 686 x10 -3 mm 2 /s and 0.643 + 0.112 x10 -3 mm 2 /s (mean + SD), respectively There is a significant difference in the mean ADC value between benign and malignant soft tissue tumors (P < 0.008) which is relatively agreed with the study of Nassif et al [13] the revealed that the ADC value of benign tumors was ranged between 2.21&2.58x10-3mm2 /sec and it was significantly higher than that of malignant soft tissue tumors which ranged between o.90&1.82x10-3mm2 /sec, where the mean ADC value of all benign soft tissue tumors was 2.21+0.27x10-3mm2 /sec, while the mean ADC value all malignant soft tissue tumors was 0.90+0.32x 10-3 mm2 /sec with statistically significant difference (p<0.001). Also, Razek et al [14] reported that malignant tumors tend to exhibit a lower mean ADC value than benign soft-tissue tumors.…”

Section: Discussionsupporting

confidence: 90%

MRI Supplemented with Diffusion Weighted Image in Characterization of Soft Tissue Masses of the Wrist and Hand

Elsharkawy

Elsadany

Younes

et al. 2022

JAMMR

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Background: The wrist joint is considered to be a condyloid synovial joint of the distal upper limb that connects and serves as a transition point between the forearm and hand. Hand and wrist soft tissue masses comprise a special subset of soft tissue masses. MRI imaging has an important role in characterization of soft tissue tumors, yet, it lacks specificity for differentiation between benign and malignant lesions.Diffusion-weighted imaging (DWI) is a non-invasive method for investigation of tumor histological content and used for differentiation between benign and malignant masses. Aims: This study aimed at assessment of the role of MR diffusion Weighted imaging (DWI) in the evaluation of soft tissue masses of the wrist and hand. Patients and Methods: This study conducted on 30 patients with soft tissue masses of the wrist and hand. They were referred from Orthopedic and Physiotherapy Departments to MRI unit in Radio-diagnosis Department, Tanta University Hospital. The study was conducted from November 2018 to November 2019. MRI with DWI was conducted for each one of them and results were correlated with histopathological examination. Results: There is a significant difference in the mean ADC value between benign and malignant soft tissue tumors. Increased apparent diffusion coefficient (ADC) values represent an increase in extracellular water or loss of cell membrane integrity whereas decreased ADC values reflect decrease in extracellular water content or increase in cell number or size. Conclusions: this study proved the role of MRI and supplementary Diffusion weighted image (DWI) with numerical ADC values in characterization of soft tissue masses of the wrist and hand.

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Section: Discussionsupporting

confidence: 90%

MRI Supplemented with Diffusion Weighted Image in Characterization of Soft Tissue Masses of the Wrist and Hand

Elsharkawy

Elsadany

Younes

et al. 2022

JAMMR

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“…Our results matched with a study done in 2017 (15) It also matched another study published in 2015 (16) in which the mean ADC value of benign masses was 2.31±1.29 x10 -3 mm 2 /sec and mean ADC value of malignant masses was 0.90 ± 0.70 x10 -3 mm 2 /sec with statistically significant difference (p<0.001).…”

Section: The Prognostic Value Of Dwi Mri In the Diagnosis Of Soft Tissue Sarcomas 2021supporting

confidence: 91%

The Prognostic Value of DWI MRI in The Diagnosis Of Soft Tissue Sarcomas

Refaat

Aziz

Hamdi

2021

Benha Medical Journal

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Background: DWI is beneficial in evaluation of soft tissue sarcomas, thus improving the diagnostic accuracy, characterization and response to treatment. Purpose: The aim of this study was to evaluate the benefit of using quantitative diffusion-weighted imaging (DWI) with apparent diffusion coefficient (ADC) mapping in the diagnosis of soft tissue sarcoma, with emphasis on its prognostic value. Patients and Methods: This study included 50 patients with pathologically proven soft tissue sarcoma. The DWI was obtained with 3 b values, including 0, 400, and 800 s/mm². Calculation of the ADC value of the lesion was done by placing the region of interest (ROI) to include the largest area of the lesion. ADC values were compared with the histopathology. Results: The most frequent site was thigh (48.0), followed by shoulder, forearm, arm and foot (8.0% for each). The most frequent pathology was synovial sarcoma (32.0%) followed by spindle cell sarcoma (28.0%) then liposarcoma (12.0%). 80% of lesions showed restricted diffusion. Median ADC value was 0.7 and ranged from 0.5 to 2.4. All patients underwent surgery, 48.0% of patients received chemotherapy and 52.0% received radiotherapy. 56.0% of patients showed recurrence, while 44.0% showed metastasis. Mean follow up duration was 13 months with standard deviation of 5 months. Median ADC value was significantly higher in patients with no recurrence (0.9) compared to those with recurrence (0.7).P value was 0.016. Conclusion: DWI with ADC mapping of soft tissue sarcoma has additive role to anatomic sequences for lesion characterization and grading as well as treatment response.

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“…los benignos, altos. Esto fue confirmado en nuestro trabajo en coincidencia con la literatura 19,[22][23][24][25][26][27][28] .…”

Section: Discussionunclassified

“…En lo que respecta a la edad de los pacientes, en nuestro trabajo encontramos similitud con el de Nassif et al 26 , con una edad promedio de 44 ± 19,5 años. Los pacientes con tumores malignos presentaron un promedio mayor de edad que los que tuvieron tumores benignos, y la diferencia fue estadísticamente significativa.…”

Section: Discussionunclassified

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

Re¹,

Cabral²,

Zenklusen³

et al. 2023

RAR

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Introducción: La imagen ponderada en difusión es una técnica de imagen funcional que aporta información complementaria a las secuencias convencionales de resonancia magnética. El coeficiente de difusión aparente (CDA) se valora junto con la secuencia de difusión, calculando el logaritmo negativo de la proporción de intensidades de dos conjuntos de imágenes, lo que permite el análisis cuantitativo de la restricción a la difusión. Objetivo: Determinar si existe una diferencia significativa entre los valores de CDA de las lesiones musculoesqueléticas benignas y malignas, correlacionando los resultados con los hallazgos histológicos. Método: Estudio prospectivo, observacional y descriptivo. Se incluyeron en el trabajo pacientes con sospecha de lesiones tumorales del sistema musculoesquelético de cualquier edad y sexo, sin antecedentes de radioterapia previa o cirugía, evaluados con resonancia magnética y con posterior biopsia o cirugía. Resultados: Se incluyeron 170 pacientes, de los cuales 80 (44 benignos) eran hombres y 90 (43 benignos) eran mujeres. El total fue de 87 lesiones benignas y 83 lesiones malignas, con una media de CDA de 1,44 ± 0,55 × 10 −3 mm 2 /s y de 0,96 ± 0,4 × 10 −3 mm 2 /s, respectivamente, con una diferencia estadísticamente significativa (p < 0,001; 6,335; 168). Conclusiones: Los valores de difusión, y particularmente el CDA, han aportado información adicional en la caracterización de los tumores benignos y malignos, con diferencia significativa, estableciendo valores altos de CDA para los tumores benignos.

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The Role of Diffusion-Weighted MRI in the Characterization of Musculoskeletal Soft Tissue Tumors

Cited by 4 publications

References 8 publications

MRI Supplemented with Diffusion Weighted Image in Characterization of Soft Tissue Masses of the Wrist and Hand

MRI Supplemented with Diffusion Weighted Image in Characterization of Soft Tissue Masses of the Wrist and Hand

The Prognostic Value of DWI MRI in The Diagnosis Of Soft Tissue Sarcomas

Diferenciación de la patología tumoral musculoesquelética benigna y maligna utilizando la técnica de difusión con resonancia magnética

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